Genome analysis of triploid hybrid Leishmania parasite from the neotropics

Frederik Van den Broeck; Senne Heeren; Ilse Maes; Mandy Sanders; James A Cotton; Elisa Cupolillo; Eugenia Alvarez; Lineth Garcia; Maureen Tasia; Alice Marneffe; Jean-Claude Dujardin; Gert Van der Auwera

doi:10.3201/eid2905.221456

Genome analysis of triploid hybrid Leishmania parasite from the neotropics

Frederik Van den Broeck, Senne Heeren, Ilse Maes, Mandy Sanders, James A Cotton, Elisa Cupolillo, Eugenia Alvarez, Lineth Garcia, Maureen Tasia, Alice Marneffe, Jean-Claude Dujardin, Gert Van der Auwera

Molecular Parasitology

Research output: Contribution to journal › A1: Web of Science-article › peer-review

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Abstract

We discovered a hybrid Leishmania parasite in Costa Rica that is genetically similar to hybrids from Panama. Genome analyses demonstrated the hybrid is triploid and identified L. braziliensis and L. guyanensis-related strains as parents. Our findings highlight the existence of poorly sampled Leishmania (Viannia) variants infectious to humans.

Original language	English
Journal	Emerging Infectious Diseases
Volume	29
Issue number	5
Pages (from-to)	1076-1078
Number of pages	3
ISSN	1080-6040
DOIs	https://doi.org/10.3201/eid2905.221456
Publication status	Published - 2023

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10.3201/eid2905.221456Licence: CC BY

2023eidi1076Final published version, 478 KBLicence: CC BY

LeishEvol: Viral evolutionary analyses as a magnifying glass on parasite population dynamics
Van den Broeck, F., Heeren, S., Lemey, P., Arevalo, J., Cupolillo, E., Dujardin, J. & Dujardin, J.
Research Fund - Flanders
1/01/21 → 31/12/25
Project: Research Project

Cite this

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title = "Genome analysis of triploid hybrid Leishmania parasite from the neotropics",

abstract = "We discovered a hybrid Leishmania parasite in Costa Rica that is genetically similar to hybrids from Panama. Genome analyses demonstrated the hybrid is triploid and identified L. braziliensis and L. guyanensis-related strains as parents. Our findings highlight the existence of poorly sampled Leishmania (Viannia) variants infectious to humans.",

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AU - Van den Broeck, Frederik

AU - Heeren, Senne

AU - Maes, Ilse

AU - Sanders, Mandy

AU - Cotton, James A

AU - Cupolillo, Elisa

AU - Alvarez, Eugenia

AU - Garcia, Lineth

AU - Tasia, Maureen

AU - Marneffe, Alice

AU - Dujardin, Jean-Claude

AU - Van der Auwera, Gert

N1 - FTX; DOAJ; (CC BY 4.0)

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Y1 - 2023

N2 - We discovered a hybrid Leishmania parasite in Costa Rica that is genetically similar to hybrids from Panama. Genome analyses demonstrated the hybrid is triploid and identified L. braziliensis and L. guyanensis-related strains as parents. Our findings highlight the existence of poorly sampled Leishmania (Viannia) variants infectious to humans.

AB - We discovered a hybrid Leishmania parasite in Costa Rica that is genetically similar to hybrids from Panama. Genome analyses demonstrated the hybrid is triploid and identified L. braziliensis and L. guyanensis-related strains as parents. Our findings highlight the existence of poorly sampled Leishmania (Viannia) variants infectious to humans.

U2 - 10.3201/eid2905.221456

DO - 10.3201/eid2905.221456

M3 - A1: Web of Science-article

C2 - 37081624

SN - 1080-6040

VL - 29

SP - 1076

EP - 1078

JO - Emerging Infectious Diseases

JF - Emerging Infectious Diseases

IS - 5

ER -

Genome analysis of triploid hybrid Leishmania parasite from the neotropics

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LeishEvol: Viral evolutionary analyses as a magnifying glass on parasite population dynamics

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