Genome sequence of the tsetse fly (Glossina morsitans): vector of African trypanosomiasis

International Glossina Genomics Initiative

    Research output: Contribution to journalA1: Web of Science-articlepeer-review


    Tsetse flies are the sole vectors of human African trypanosomiasis throughout sub-Saharan Africa. Both sexes of adult tsetse feed exclusively on blood and contribute to disease transmission. Notable differences between tsetse and other disease vectors include obligate microbial symbioses, viviparous reproduction, and lactation. Here, we describe the sequence and annotation of the 366-megabase Glossina morsitans morsitans genome. Analysis of the genome and the 12,308 predicted protein-encoding genes led to multiple discoveries, including chromosomal integrations of bacterial (Wolbachia) genome sequences, a family of lactation-specific proteins, reduced complement of host pathogen recognition proteins, and reduced olfaction/chemosensory associated genes. These genome data provide a foundation for research into trypanosomiasis prevention and yield important insights with broad implications for multiple aspects of tsetse biology.

    Original languageEnglish
    Issue number6182
    Pages (from-to)380-386
    Number of pages7
    Publication statusPublished - 2014


    • Animals
    • Blood
    • Feeding Behavior
    • Female
    • Genes, Insect
    • Genome, Insect
    • Insect Proteins
    • Insect Vectors
    • Microbiota
    • Molecular Sequence Annotation
    • Molecular Sequence Data
    • Reproduction
    • Salivary Glands
    • Sensation
    • Sequence Analysis, DNA
    • Symbiosis
    • Trypanosoma
    • Trypanosomiasis, African
    • Tsetse Flies
    • Wolbachia


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