Genome-wide SNP analysis reveals distinct origins of Trypanosoma evansi and Trypanosoma equiperdum

Bart Cuypers; Frederik Van den Broeck; Nick Van Reet; Conor J Meehan; Julien Cauchard; Jonathan M Wilkes; Filip Claes; Bruno Goddeeris; Hadush Birhanu; Jean-Claude Dujardin; Kris Laukens; Philippe Büscher; Stijn Deborggraeve

doi:10.1093/gbe/evx102

Genome-wide SNP analysis reveals distinct origins of Trypanosoma evansi and Trypanosoma equiperdum

Bart Cuypers, Frederik Van den Broeck, Nick Van Reet, Conor J Meehan, Julien Cauchard, Jonathan M Wilkes, Filip Claes, Bruno Goddeeris, Hadush Birhanu, Jean-Claude Dujardin, Kris Laukens, Philippe Büscher, Stijn Deborggraeve

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Abstract

Trypanosomes cause a variety of diseases in man and domestic animals in Africa, Latin America and Asia. In the Trypanozoon subgenus, Trypanosoma brucei gambiense and T. b. rhodesiense cause human African trypanosomiasis, while T. b. brucei, T. evansi and T. equiperdum are responsible for nagana, surra and dourine in domestic animals, respectively. The genetic relationships between T. evansi and T. equiperdum and other Trypanozoon species remain unclear because the majority of phylogenetic analyses have been based on only a few genes. In this study, we have conducted a phylogenetic analysis based on genome-wide SNP analysis comprising 56 genomes from the Trypanozoon subgenus. Our data reveal that T. equiperdum has emerged at least once in Eastern Africa and T. evansi at two independent occasions in Western Africa. The genomes within the T. equiperdum and T. evansi monophyletic clusters show extremely little variation, probably due to the clonal spread linked to the independence from tsetse flies for their transmission.

Original language	English
Journal	Genome Biology and Evolution
Volume	9
Issue number	8
Pages (from-to)	1990-1997
Number of pages	8
ISSN	1759-6653
DOIs	https://doi.org/10.1093/gbe/evx102
Publication status	Published - 2017

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Cuypers, B., Van den Broeck, F., Van Reet, N., Meehan, C. J., Cauchard, J., Wilkes, J. M., Claes, F., Goddeeris, B., Birhanu, H., Dujardin, J.-C., Laukens, K., Büscher, P., & Deborggraeve, S. (2017). Genome-wide SNP analysis reveals distinct origins of Trypanosoma evansi and Trypanosoma equiperdum. Genome Biology and Evolution, 9(8), 1990-1997. https://doi.org/10.1093/gbe/evx102

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title = "Genome-wide SNP analysis reveals distinct origins of Trypanosoma evansi and Trypanosoma equiperdum",

abstract = "Trypanosomes cause a variety of diseases in man and domestic animals in Africa, Latin America and Asia. In the Trypanozoon subgenus, Trypanosoma brucei gambiense and T. b. rhodesiense cause human African trypanosomiasis, while T. b. brucei, T. evansi and T. equiperdum are responsible for nagana, surra and dourine in domestic animals, respectively. The genetic relationships between T. evansi and T. equiperdum and other Trypanozoon species remain unclear because the majority of phylogenetic analyses have been based on only a few genes. In this study, we have conducted a phylogenetic analysis based on genome-wide SNP analysis comprising 56 genomes from the Trypanozoon subgenus. Our data reveal that T. equiperdum has emerged at least once in Eastern Africa and T. evansi at two independent occasions in Western Africa. The genomes within the T. equiperdum and T. evansi monophyletic clusters show extremely little variation, probably due to the clonal spread linked to the independence from tsetse flies for their transmission.",

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Cuypers, B, Van den Broeck, F, Van Reet, N, Meehan, CJ, Cauchard, J, Wilkes, JM, Claes, F, Goddeeris, B, Birhanu, H, Dujardin, J-C, Laukens, K, Büscher, P & Deborggraeve, S 2017, 'Genome-wide SNP analysis reveals distinct origins of Trypanosoma evansi and Trypanosoma equiperdum', Genome Biology and Evolution, vol. 9, no. 8, pp. 1990-1997. https://doi.org/10.1093/gbe/evx102

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T1 - Genome-wide SNP analysis reveals distinct origins of Trypanosoma evansi and Trypanosoma equiperdum

AU - Cuypers, Bart

AU - Van den Broeck, Frederik

AU - Van Reet, Nick

AU - Meehan, Conor J

AU - Cauchard, Julien

AU - Wilkes, Jonathan M

AU - Claes, Filip

AU - Goddeeris, Bruno

AU - Birhanu, Hadush

AU - Dujardin, Jean-Claude

AU - Laukens, Kris

AU - Büscher, Philippe

AU - Deborggraeve, Stijn

N1 - FTX

PY - 2017

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N2 - Trypanosomes cause a variety of diseases in man and domestic animals in Africa, Latin America and Asia. In the Trypanozoon subgenus, Trypanosoma brucei gambiense and T. b. rhodesiense cause human African trypanosomiasis, while T. b. brucei, T. evansi and T. equiperdum are responsible for nagana, surra and dourine in domestic animals, respectively. The genetic relationships between T. evansi and T. equiperdum and other Trypanozoon species remain unclear because the majority of phylogenetic analyses have been based on only a few genes. In this study, we have conducted a phylogenetic analysis based on genome-wide SNP analysis comprising 56 genomes from the Trypanozoon subgenus. Our data reveal that T. equiperdum has emerged at least once in Eastern Africa and T. evansi at two independent occasions in Western Africa. The genomes within the T. equiperdum and T. evansi monophyletic clusters show extremely little variation, probably due to the clonal spread linked to the independence from tsetse flies for their transmission.

AB - Trypanosomes cause a variety of diseases in man and domestic animals in Africa, Latin America and Asia. In the Trypanozoon subgenus, Trypanosoma brucei gambiense and T. b. rhodesiense cause human African trypanosomiasis, while T. b. brucei, T. evansi and T. equiperdum are responsible for nagana, surra and dourine in domestic animals, respectively. The genetic relationships between T. evansi and T. equiperdum and other Trypanozoon species remain unclear because the majority of phylogenetic analyses have been based on only a few genes. In this study, we have conducted a phylogenetic analysis based on genome-wide SNP analysis comprising 56 genomes from the Trypanozoon subgenus. Our data reveal that T. equiperdum has emerged at least once in Eastern Africa and T. evansi at two independent occasions in Western Africa. The genomes within the T. equiperdum and T. evansi monophyletic clusters show extremely little variation, probably due to the clonal spread linked to the independence from tsetse flies for their transmission.

KW - Journal Article

U2 - 10.1093/gbe/evx102

DO - 10.1093/gbe/evx102

M3 - A1: Web of Science-article

C2 - 28541535

SN - 1759-6653

VL - 9

SP - 1990

EP - 1997

JO - Genome Biology and Evolution

JF - Genome Biology and Evolution

IS - 8

ER -

Genome-wide SNP analysis reveals distinct origins of Trypanosoma evansi and Trypanosoma equiperdum

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