Genomic characterization of Leishmania tropica in cutaneous Leishmaniasis, Somali Region, Ethiopia, 2023

Adugna Abera; Pieter Monsieurs; Myrthe Pareyn; Dereje Beyene; Geremew Tasew; Allison Aroni-Soto; Mahlet Belachew; Desalegn Geleta; Bethlehem Adnew; Bokretsion Gidey; Henok Tadesse; Atsbeha Gebreegziabxier; Rajiha Abubeker; Abraham Ali; Ketema Tafess; Tobias F Rinke de Wit; Johan van Griensven; Jean-Claude Dujardin; Dawit Wolday; Malgorzata Anna Domagalska

doi:10.3201/eid3107.241607

Genomic characterization of Leishmania tropica in cutaneous Leishmaniasis, Somali Region, Ethiopia, 2023

Adugna Abera, Pieter Monsieurs, Myrthe Pareyn, Dereje Beyene, Geremew Tasew, Allison Aroni-Soto, Mahlet Belachew, Desalegn Geleta, Bethlehem Adnew, Bokretsion Gidey, Henok Tadesse, Atsbeha Gebreegziabxier, Rajiha Abubeker, Abraham Ali, Ketema Tafess, Tobias F Rinke de Wit, Johan van Griensven, Jean-Claude Dujardin, Dawit Wolday, Malgorzata Anna Domagalska

Research output: Contribution to journal › Letter › peer-review

Abstract

We sequenced Leishmania tropica genomes from 8 human skin samples collected in a newly emerging focus of cutaneous leishmaniasis in the Somali region of Ethiopia. We found a variant with unique genomic signatures of drug resistance. Public health officials should use genomic surveillance to slow expansion of L. tropica.

Original language	English
Journal	Emerging Infectious Diseases
Volume	31
Issue number	7
Pages (from-to)	1483-1486
Number of pages	4
ISSN	1080-6040
DOIs	https://doi.org/10.3201/eid3107.241607
Publication status	Published - 2025

Keywords

Leishmania tropica/genetics
Leishmaniasis, Cutaneous/epidemiology
Humans
Ethiopia/epidemiology
Genome, Protozoan
Genomics
Somalia/epidemiology
Phylogeny

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Abera, A., Monsieurs, P., Pareyn, M., Beyene, D., Tasew, G., Aroni-Soto, A., Belachew, M., Geleta, D., Adnew, B., Gidey, B., Tadesse, H., Gebreegziabxier, A., Abubeker, R., Ali, A., Tafess, K., de Wit, T. F. R., van Griensven, J., Dujardin, J.-C., Wolday, D., & Domagalska, M. A. (2025). Genomic characterization of Leishmania tropica in cutaneous Leishmaniasis, Somali Region, Ethiopia, 2023. Emerging Infectious Diseases, 31(7), 1483-1486. https://doi.org/10.3201/eid3107.241607

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abstract = "We sequenced Leishmania tropica genomes from 8 human skin samples collected in a newly emerging focus of cutaneous leishmaniasis in the Somali region of Ethiopia. We found a variant with unique genomic signatures of drug resistance. Public health officials should use genomic surveillance to slow expansion of L. tropica.",

keywords = "Leishmania tropica/genetics, Leishmaniasis, Cutaneous/epidemiology, Humans, Ethiopia/epidemiology, Genome, Protozoan, Genomics, Somalia/epidemiology, Phylogeny",

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Abera, A, Monsieurs, P , Pareyn, M, Beyene, D, Tasew, G, Aroni-Soto, A, Belachew, M, Geleta, D, Adnew, B, Gidey, B, Tadesse, H, Gebreegziabxier, A, Abubeker, R, Ali, A, Tafess, K, de Wit, TFR, van Griensven, J , Dujardin, J-C, Wolday, D & Domagalska, MA 2025, 'Genomic characterization of Leishmania tropica in cutaneous Leishmaniasis, Somali Region, Ethiopia, 2023', Emerging Infectious Diseases, vol. 31, no. 7, pp. 1483-1486. https://doi.org/10.3201/eid3107.241607

TY - JOUR

T1 - Genomic characterization of Leishmania tropica in cutaneous Leishmaniasis, Somali Region, Ethiopia, 2023

AU - Abera, Adugna

AU - Monsieurs, Pieter

AU - Pareyn, Myrthe

AU - Beyene, Dereje

AU - Tasew, Geremew

AU - Aroni-Soto, Allison

AU - Belachew, Mahlet

AU - Geleta, Desalegn

AU - Adnew, Bethlehem

AU - Gidey, Bokretsion

AU - Tadesse, Henok

AU - Gebreegziabxier, Atsbeha

AU - Abubeker, Rajiha

AU - Ali, Abraham

AU - Tafess, Ketema

AU - de Wit, Tobias F Rinke

AU - van Griensven, Johan

AU - Dujardin, Jean-Claude

AU - Wolday, Dawit

AU - Domagalska, Malgorzata Anna

N1 - FTX: (CC0)

PY - 2025

Y1 - 2025

N2 - We sequenced Leishmania tropica genomes from 8 human skin samples collected in a newly emerging focus of cutaneous leishmaniasis in the Somali region of Ethiopia. We found a variant with unique genomic signatures of drug resistance. Public health officials should use genomic surveillance to slow expansion of L. tropica.

AB - We sequenced Leishmania tropica genomes from 8 human skin samples collected in a newly emerging focus of cutaneous leishmaniasis in the Somali region of Ethiopia. We found a variant with unique genomic signatures of drug resistance. Public health officials should use genomic surveillance to slow expansion of L. tropica.

KW - Leishmania tropica/genetics

KW - Leishmaniasis, Cutaneous/epidemiology

KW - Humans

KW - Ethiopia/epidemiology

KW - Genome, Protozoan

KW - Genomics

KW - Somalia/epidemiology

KW - Phylogeny

UR - https://www.webofscience.com/wos/woscc/full-record/WOS:001524063600034

U2 - 10.3201/eid3107.241607

DO - 10.3201/eid3107.241607

M3 - Letter

C2 - 40562735

SN - 1080-6040

VL - 31

SP - 1483

EP - 1486

JO - Emerging Infectious Diseases

JF - Emerging Infectious Diseases

IS - 7

ER -

Genomic characterization of Leishmania tropica in cutaneous Leishmaniasis, Somali Region, Ethiopia, 2023

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