Genomic profiling of climate adaptation in Aedes aegypti along an altitudinal gradient in Nepal indicates nongradual expansion of the disease vector

Isabelle Marie Kramer; Markus Pfenninger; Barbara Feldmeyer; Meghnath Dhimal; Ishan Gautam; Pramod Shreshta; Sunita Baral; Parbati Phuyal; Juliane Hartke; Axel Magdeburg; David A. Groneberg; Bodo Ahrens; Ruth Müller; Ann-Marie Waldvogel

doi:10.1111/mec.16752

Genomic profiling of climate adaptation in Aedes aegypti along an altitudinal gradient in Nepal indicates nongradual expansion of the disease vector

Isabelle Marie Kramer, Markus Pfenninger, Barbara Feldmeyer, Meghnath Dhimal, Ishan Gautam, Pramod Shreshta, Sunita Baral, Parbati Phuyal, Juliane Hartke, Axel Magdeburg, David A. Groneberg, Bodo Ahrens, Ruth Müller, Ann-Marie Waldvogel

Entomology

Research output: Contribution to journal › A1: Web of Science-article › peer-review

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Abstract

Driven by globalization, urbanization and climate change, the distribution range of invasive vector species has expanded to previously colder ecoregions. To reduce health-threatening impacts on humans, insect vectors are extensively studied. Population genomics can reveal the genomic basis of adaptation and help to identify emerging trends of vector expansion. By applying whole genome analyses and genotype-environment associations to populations of the main dengue vector Aedes aegypti, sampled along an altitudinal gradient in Nepal (200-1300 m), we identify putatively adaptive traits and describe the species' genomic footprint of climate adaptation to colder ecoregions. We found two differentiated clusters with significantly different allele frequencies in genes associated to climate adaptation between the highland population (1300 m) and all other lowland populations (

Original language	English
Journal	Molecular Ecology
Number of pages	19
ISSN	0962-1083
DOIs	https://doi.org/10.1111/mec.16752
Publication status	E-pub ahead of print - 2022

Keywords

climate change genomics
latent factor mixed model
range expansion
whole genome pooled sequencing
yellow fever mosquito
LOCAL ADAPTATION
DROSOPHILA-MELANOGASTER
WIDE PATTERNS
DIFFERENTIATION
DENGUE
IDENTIFICATION
URBANIZATION
ASSOCIATION
TEMPERATURE
POPULATIONS

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10.1111/mec.16752Licence: CC BY-NC

2022meco0001Final published version, 2.63 MBLicence: CC BY-NC

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Kramer, I. M., Pfenninger, M., Feldmeyer, B., Dhimal, M., Gautam, I., Shreshta, P., Baral, S., Phuyal, P., Hartke, J., Magdeburg, A., Groneberg, D. A., Ahrens, B., Müller, R., & Waldvogel, A.-M. (2022). Genomic profiling of climate adaptation in Aedes aegypti along an altitudinal gradient in Nepal indicates nongradual expansion of the disease vector. Molecular Ecology. Advance online publication. https://doi.org/10.1111/mec.16752

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abstract = "Driven by globalization, urbanization and climate change, the distribution range of invasive vector species has expanded to previously colder ecoregions. To reduce health-threatening impacts on humans, insect vectors are extensively studied. Population genomics can reveal the genomic basis of adaptation and help to identify emerging trends of vector expansion. By applying whole genome analyses and genotype-environment associations to populations of the main dengue vector Aedes aegypti, sampled along an altitudinal gradient in Nepal (200-1300 m), we identify putatively adaptive traits and describe the species' genomic footprint of climate adaptation to colder ecoregions. We found two differentiated clusters with significantly different allele frequencies in genes associated to climate adaptation between the highland population (1300 m) and all other lowland populations (",

keywords = "climate change genomics, latent factor mixed model, range expansion, whole genome pooled sequencing, yellow fever mosquito, LOCAL ADAPTATION, DROSOPHILA-MELANOGASTER, WIDE PATTERNS, DIFFERENTIATION, DENGUE, IDENTIFICATION, URBANIZATION, ASSOCIATION, TEMPERATURE, POPULATIONS",

author = "Kramer, {Isabelle Marie} and Markus Pfenninger and Barbara Feldmeyer and Meghnath Dhimal and Ishan Gautam and Pramod Shreshta and Sunita Baral and Parbati Phuyal and Juliane Hartke and Axel Magdeburg and Groneberg, {David A.} and Bodo Ahrens and Ruth M{\"u}ller and Ann-Marie Waldvogel",

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Kramer, IM, Pfenninger, M, Feldmeyer, B, Dhimal, M, Gautam, I, Shreshta, P, Baral, S, Phuyal, P, Hartke, J, Magdeburg, A, Groneberg, DA, Ahrens, B, Müller, R & Waldvogel, A-M 2022, 'Genomic profiling of climate adaptation in Aedes aegypti along an altitudinal gradient in Nepal indicates nongradual expansion of the disease vector', Molecular Ecology. https://doi.org/10.1111/mec.16752

TY - JOUR

T1 - Genomic profiling of climate adaptation in Aedes aegypti along an altitudinal gradient in Nepal indicates nongradual expansion of the disease vector

AU - Kramer, Isabelle Marie

AU - Pfenninger, Markus

AU - Feldmeyer, Barbara

AU - Dhimal, Meghnath

AU - Gautam, Ishan

AU - Shreshta, Pramod

AU - Baral, Sunita

AU - Phuyal, Parbati

AU - Hartke, Juliane

AU - Magdeburg, Axel

AU - Groneberg, David A.

AU - Ahrens, Bodo

AU - Müller, Ruth

AU - Waldvogel, Ann-Marie

N1 - FTX; (CC BY-NC 4.0)

PY - 2022

Y1 - 2022

N2 - Driven by globalization, urbanization and climate change, the distribution range of invasive vector species has expanded to previously colder ecoregions. To reduce health-threatening impacts on humans, insect vectors are extensively studied. Population genomics can reveal the genomic basis of adaptation and help to identify emerging trends of vector expansion. By applying whole genome analyses and genotype-environment associations to populations of the main dengue vector Aedes aegypti, sampled along an altitudinal gradient in Nepal (200-1300 m), we identify putatively adaptive traits and describe the species' genomic footprint of climate adaptation to colder ecoregions. We found two differentiated clusters with significantly different allele frequencies in genes associated to climate adaptation between the highland population (1300 m) and all other lowland populations (

AB - Driven by globalization, urbanization and climate change, the distribution range of invasive vector species has expanded to previously colder ecoregions. To reduce health-threatening impacts on humans, insect vectors are extensively studied. Population genomics can reveal the genomic basis of adaptation and help to identify emerging trends of vector expansion. By applying whole genome analyses and genotype-environment associations to populations of the main dengue vector Aedes aegypti, sampled along an altitudinal gradient in Nepal (200-1300 m), we identify putatively adaptive traits and describe the species' genomic footprint of climate adaptation to colder ecoregions. We found two differentiated clusters with significantly different allele frequencies in genes associated to climate adaptation between the highland population (1300 m) and all other lowland populations (

KW - climate change genomics

KW - latent factor mixed model

KW - range expansion

KW - whole genome pooled sequencing

KW - yellow fever mosquito

KW - LOCAL ADAPTATION

KW - DROSOPHILA-MELANOGASTER

KW - WIDE PATTERNS

KW - DIFFERENTIATION

KW - DENGUE

KW - IDENTIFICATION

KW - URBANIZATION

KW - ASSOCIATION

KW - TEMPERATURE

KW - POPULATIONS

U2 - 10.1111/mec.16752

DO - 10.1111/mec.16752

M3 - A1: Web of Science-article

SN - 0962-1083

JO - Molecular Ecology

JF - Molecular Ecology

ER -

Genomic profiling of climate adaptation in Aedes aegypti along an altitudinal gradient in Nepal indicates nongradual expansion of the disease vector

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Keywords

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