Genomic profiling of climate adaptation in Aedes aegypti along an altitudinal gradient in Nepal indicates nongradual expansion of the disease vector

Isabelle Marie Kramer, Markus Pfenninger, Barbara Feldmeyer, Meghnath Dhimal, Ishan Gautam, Pramod Shreshta, Sunita Baral, Parbati Phuyal, Juliane Hartke, Axel Magdeburg, David A. Groneberg, Bodo Ahrens, Ruth Müller, Ann-Marie Waldvogel

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Abstract

Driven by globalization, urbanization and climate change, the distribution range of invasive vector species has expanded to previously colder ecoregions. To reduce health-threatening impacts on humans, insect vectors are extensively studied. Population genomics can reveal the genomic basis of adaptation and help to identify emerging trends of vector expansion. By applying whole genome analyses and genotype-environment associations to populations of the main dengue vector Aedes aegypti, sampled along an altitudinal gradient in Nepal (200-1300 m), we identify putatively adaptive traits and describe the species' genomic footprint of climate adaptation to colder ecoregions. We found two differentiated clusters with significantly different allele frequencies in genes associated to climate adaptation between the highland population (1300 m) and all other lowland populations (

Original languageEnglish
JournalMolecular Ecology
Number of pages19
ISSN0962-1083
DOIs
Publication statusE-pub ahead of print - 2022

Keywords

  • climate change genomics
  • latent factor mixed model
  • range expansion
  • whole genome pooled sequencing
  • yellow fever mosquito
  • LOCAL ADAPTATION
  • DROSOPHILA-MELANOGASTER
  • WIDE PATTERNS
  • DIFFERENTIATION
  • DENGUE
  • IDENTIFICATION
  • URBANIZATION
  • ASSOCIATION
  • TEMPERATURE
  • POPULATIONS

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