Global and regional dissemination and evolution of Burkholderia pseudomallei

Claire Chewapreecha; Matthew T G Holden; Minna Vehkala; Niko Välimäki; Zhirong Yang; Simon R Harris; Alison E Mather; Apichai Tuanyok; Birgit De Smet; Simon Le Hello; Chantal Bizet; Mark Mayo; Vanaporn Wuthiekanun; Direk Limmathurotsakul; Rattanaphone Phetsouvanh; Brian G Spratt; Jukka Corander; Paul Keim; Gordon Dougan; David A B Dance; Bart J Currie; Julian Parkhill; Sharon J Peacock

doi:10.1038/nmicrobiol.2016.263

Global and regional dissemination and evolution of Burkholderia pseudomallei

Claire Chewapreecha, Matthew T G Holden, Minna Vehkala, Niko Välimäki, Zhirong Yang, Simon R Harris, Alison E Mather, Apichai Tuanyok, Birgit De Smet, Simon Le Hello, Chantal Bizet, Mark Mayo, Vanaporn Wuthiekanun, Direk Limmathurotsakul, Rattanaphone Phetsouvanh, Brian G Spratt, Jukka Corander, Paul Keim, Gordon Dougan, David A B DanceBart J Currie, Julian Parkhill, Sharon J Peacock

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Abstract

The environmental bacterium Burkholderia pseudomallei causes an estimated 165,000 cases of human melioidosis per year worldwide and is also classified as a biothreat agent. We used whole genome sequences of 469 B. pseudomallei isolates from 30 countries collected over 79 years to explore its geographic transmission. Our data point to Australia as an early reservoir, with transmission to Southeast Asia followed by onward transmission to South Asia and East Asia. Repeated reintroductions were observed within the Malay Peninsula and between countries bordered by the Mekong River. Our data support an African origin of the Central and South American isolates with introduction of B. pseudomallei into the Americas between 1650 and 1850, providing a temporal link with the slave trade. We also identified geographically distinct genes/variants in Australasian or Southeast Asian isolates alone, with virulence-associated genes being among those over-represented. This provides a potential explanation for clinical manifestations of melioidosis that are geographically restricted.

Original language	English
Article number	16263
Journal	Nature Microbiology
Volume	2
Number of pages	8
ISSN	2058-5276
DOIs	https://doi.org/10.1038/nmicrobiol.2016.263
Publication status	Published - 2017

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Chewapreecha, C., Holden, M. T. G., Vehkala, M., Välimäki, N., Yang, Z., Harris, S. R., Mather, A. E., Tuanyok, A., De Smet, B., Le Hello, S., Bizet, C., Mayo, M., Wuthiekanun, V., Limmathurotsakul, D., Phetsouvanh, R., Spratt, B. G., Corander, J., Keim, P., Dougan, G., ... Peacock, S. J. (2017). Global and regional dissemination and evolution of Burkholderia pseudomallei. Nature Microbiology, 2, Article 16263. https://doi.org/10.1038/nmicrobiol.2016.263

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title = "Global and regional dissemination and evolution of Burkholderia pseudomallei",

abstract = "The environmental bacterium Burkholderia pseudomallei causes an estimated 165,000 cases of human melioidosis per year worldwide and is also classified as a biothreat agent. We used whole genome sequences of 469 B. pseudomallei isolates from 30 countries collected over 79 years to explore its geographic transmission. Our data point to Australia as an early reservoir, with transmission to Southeast Asia followed by onward transmission to South Asia and East Asia. Repeated reintroductions were observed within the Malay Peninsula and between countries bordered by the Mekong River. Our data support an African origin of the Central and South American isolates with introduction of B. pseudomallei into the Americas between 1650 and 1850, providing a temporal link with the slave trade. We also identified geographically distinct genes/variants in Australasian or Southeast Asian isolates alone, with virulence-associated genes being among those over-represented. This provides a potential explanation for clinical manifestations of melioidosis that are geographically restricted.",

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language = "English",

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journal = "Nature Microbiology",

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Chewapreecha, C, Holden, MTG, Vehkala, M, Välimäki, N, Yang, Z, Harris, SR, Mather, AE, Tuanyok, A, De Smet, B, Le Hello, S, Bizet, C, Mayo, M, Wuthiekanun, V, Limmathurotsakul, D, Phetsouvanh, R, Spratt, BG, Corander, J, Keim, P, Dougan, G, Dance, DAB, Currie, BJ, Parkhill, J & Peacock, SJ 2017, 'Global and regional dissemination and evolution of Burkholderia pseudomallei', Nature Microbiology, vol. 2, 16263. https://doi.org/10.1038/nmicrobiol.2016.263

TY - JOUR

T1 - Global and regional dissemination and evolution of Burkholderia pseudomallei

AU - Chewapreecha, Claire

AU - Holden, Matthew T G

AU - Vehkala, Minna

AU - Välimäki, Niko

AU - Yang, Zhirong

AU - Harris, Simon R

AU - Mather, Alison E

AU - Tuanyok, Apichai

AU - De Smet, Birgit

AU - Le Hello, Simon

AU - Bizet, Chantal

AU - Mayo, Mark

AU - Wuthiekanun, Vanaporn

AU - Limmathurotsakul, Direk

AU - Phetsouvanh, Rattanaphone

AU - Spratt, Brian G

AU - Corander, Jukka

AU - Keim, Paul

AU - Dougan, Gordon

AU - Dance, David A B

AU - Currie, Bart J

AU - Parkhill, Julian

AU - Peacock, Sharon J

PY - 2017

Y1 - 2017

N2 - The environmental bacterium Burkholderia pseudomallei causes an estimated 165,000 cases of human melioidosis per year worldwide and is also classified as a biothreat agent. We used whole genome sequences of 469 B. pseudomallei isolates from 30 countries collected over 79 years to explore its geographic transmission. Our data point to Australia as an early reservoir, with transmission to Southeast Asia followed by onward transmission to South Asia and East Asia. Repeated reintroductions were observed within the Malay Peninsula and between countries bordered by the Mekong River. Our data support an African origin of the Central and South American isolates with introduction of B. pseudomallei into the Americas between 1650 and 1850, providing a temporal link with the slave trade. We also identified geographically distinct genes/variants in Australasian or Southeast Asian isolates alone, with virulence-associated genes being among those over-represented. This provides a potential explanation for clinical manifestations of melioidosis that are geographically restricted.

AB - The environmental bacterium Burkholderia pseudomallei causes an estimated 165,000 cases of human melioidosis per year worldwide and is also classified as a biothreat agent. We used whole genome sequences of 469 B. pseudomallei isolates from 30 countries collected over 79 years to explore its geographic transmission. Our data point to Australia as an early reservoir, with transmission to Southeast Asia followed by onward transmission to South Asia and East Asia. Repeated reintroductions were observed within the Malay Peninsula and between countries bordered by the Mekong River. Our data support an African origin of the Central and South American isolates with introduction of B. pseudomallei into the Americas between 1650 and 1850, providing a temporal link with the slave trade. We also identified geographically distinct genes/variants in Australasian or Southeast Asian isolates alone, with virulence-associated genes being among those over-represented. This provides a potential explanation for clinical manifestations of melioidosis that are geographically restricted.

KW - Journal Article

U2 - 10.1038/nmicrobiol.2016.263

DO - 10.1038/nmicrobiol.2016.263

M3 - A1: Web of Science-article

C2 - 28112723

SN - 2058-5276

VL - 2

JO - Nature Microbiology

JF - Nature Microbiology

M1 - 16263

ER -

Global and regional dissemination and evolution of Burkholderia pseudomallei

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