Hepatitis of unknown aetiology in children - epidemiological overview of cases reported in Europe, 1 January to 16 June 2022

Adriana Romaní Vidal, Aisling Vaughan, Francesco Innocenti, Soledad Colombe, Lina Nerlander, Natalia Rachwal, Bruno Christian Ciancio, Aikaterini Mougkou, Carlos Carvalho, Enrique Delgado, Piers Mook, Michael Peeters, Tencho Tenev, Elitsa Golkocheva-Markova, Veronika Vorobieva Solholm Jensen, Anders Koch, Julie Figoni, Cécile Brouard, Georgia Nikolopoulou, Anastasia ZisouliNiamh Murphy, Annemarie Broderick, Lital Goldberg, Rivka Rich, Lior Hecht Sagie, Maria Elena Tosti, Barbara Suligoi, Rosa Joosten, Roan Pijnacker, Ingvild Fjeldheim, Eli Heen, Małgorzata Stępień, Piotr Polański, Rui Tato Marinho, João Vieira Martins, Carmen Varela, Ana Avellón, Emmi Andersson, Marie Jansson Mörk, Sema Mandal, Conall Watson, Laura Coughlan, Meera Chand, Claire Neill, Declan T. Bradley, Kathy Li, Maureen O'Leary, Neil McInnes, Christopher J. Williams, Catherine Moore, Ardiana Gjini, Erika Duffell, Richard Pebody

Research output: Contribution to journalArticlepeer-review


Following the report of an excess in paediatric cases of severe acute hepatitis of unknown aetiology by the United Kingdom (UK) on 5 April 2022, 427 cases were reported from 20 countries in the World Health Organization European Region to the European Surveillance System TESSy from 1 January 2022 to 16 June 2022. Here, we analysed demographic, epidemiological, clinical and microbiological data available in TESSy. Of the reported cases, 77.3 years or younger and 53.5 10.4PCR for SARS-CoV-2 and 10.3dependency units (OR = 2.11; 95 1.18-3.74) and transplanted (OR = 3.36; 95 1.19-9.55) than cases with a negative test result for adenovirus, but this was no longer observed when looking at this association separately between the UK and other countries. Aetiological studies are needed to ascertain if adenovirus plays a role in this possible emergence of hepatitis cases in children and, if confirmed, the mechanisms that could be involved.
Original languageEnglish
Issue number31
Pages (from-to)2200483
Number of pages1
Publication statusPublished - 1-Aug-2022


  • adenovirus
  • Child
  • COVID-19
  • Europe
  • hepatitis
  • Hepatitis A
  • Hospitalization
  • Humans
  • paediatric acute liver failure
  • SARS-CoV-2
  • TESSy
  • unknown aetiology
  • WHO European Region


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