Hepatitis of unknown aetiology in children - epidemiological overview of cases reported in Europe, 1 January to 16 June 2022

Adriana Romaní Vidal; Aisling Vaughan; Francesco Innocenti; Soledad Colombe; Lina Nerlander; Natalia Rachwal; Bruno Christian Ciancio; Aikaterini Mougkou; Carlos Carvalho; Enrique Delgado; Piers Mook; Michael Peeters; Tencho Tenev; Elitsa Golkocheva-Markova; Veronika Vorobieva Solholm Jensen; Anders Koch; Julie Figoni; Cécile Brouard; Georgia Nikolopoulou; Anastasia Zisouli; Niamh Murphy; Annemarie Broderick; Lital Goldberg; Rivka Rich; Lior Hecht Sagie; Maria Elena Tosti; Barbara Suligoi; Rosa Joosten; Roan Pijnacker; Ingvild Fjeldheim; Eli Heen; Małgorzata Stępień; Piotr Polański; Rui Tato Marinho; João Vieira Martins; Carmen Varela; Ana Avellón; Emmi Andersson; Marie Jansson Mörk; Sema Mandal; Conall Watson; Laura Coughlan; Meera Chand; Claire Neill; Declan T. Bradley; Kathy Li; Maureen O'Leary; Neil McInnes; Christopher J. Williams; Catherine Moore; Ardiana Gjini; Erika Duffell; Richard Pebody

doi:10.2807/1560-7917.ES.2022.27.31.2200483

Hepatitis of unknown aetiology in children - epidemiological overview of cases reported in Europe, 1 January to 16 June 2022

Adriana Romaní Vidal, Aisling Vaughan, Francesco Innocenti, Soledad Colombe, Lina Nerlander, Natalia Rachwal, Bruno Christian Ciancio, Aikaterini Mougkou, Carlos Carvalho, Enrique Delgado, Piers Mook, Michael Peeters, Tencho Tenev, Elitsa Golkocheva-Markova, Veronika Vorobieva Solholm Jensen, Anders Koch, Julie Figoni, Cécile Brouard, Georgia Nikolopoulou, Anastasia ZisouliNiamh Murphy, Annemarie Broderick, Lital Goldberg, Rivka Rich, Lior Hecht Sagie, Maria Elena Tosti, Barbara Suligoi, Rosa Joosten, Roan Pijnacker, Ingvild Fjeldheim, Eli Heen, Małgorzata Stępień, Piotr Polański, Rui Tato Marinho, João Vieira Martins, Carmen Varela, Ana Avellón, Emmi Andersson, Marie Jansson Mörk, Sema Mandal, Conall Watson, Laura Coughlan, Meera Chand, Claire Neill, Declan T. Bradley, Kathy Li, Maureen O'Leary, Neil McInnes, Christopher J. Williams, Catherine Moore, Ardiana Gjini, Erika Duffell, Richard Pebody

Emerging Infectious Diseases

Research output: Contribution to journal › Article › peer-review

Abstract

Following the report of an excess in paediatric cases of severe acute hepatitis of unknown aetiology by the United Kingdom (UK) on 5 April 2022, 427 cases were reported from 20 countries in the World Health Organization European Region to the European Surveillance System TESSy from 1 January 2022 to 16 June 2022. Here, we analysed demographic, epidemiological, clinical and microbiological data available in TESSy. Of the reported cases, 77.3 years or younger and 53.5 10.4PCR for SARS-CoV-2 and 10.3dependency units (OR = 2.11; 95 1.18-3.74) and transplanted (OR = 3.36; 95 1.19-9.55) than cases with a negative test result for adenovirus, but this was no longer observed when looking at this association separately between the UK and other countries. Aetiological studies are needed to ascertain if adenovirus plays a role in this possible emergence of hepatitis cases in children and, if confirmed, the mechanisms that could be involved.

Original language	English
Journal	Eurosurveillance
Volume	27
Issue number	31
Pages (from-to)	2200483
Number of pages	1
ISSN	1560-7917
DOIs	https://doi.org/10.2807/1560-7917.ES.2022.27.31.2200483
Publication status	Published - 1-Aug-2022

Keywords

adenovirus
Child
COVID-19
Europe
hepatitis
Hepatitis A
Hospitalization
Humans
paediatric acute liver failure
SARS-CoV-2
TESSy
unknown aetiology
WHO European Region

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10.2807/1560-7917.ES.2022.27.31.2200483

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Romaní Vidal, A., Vaughan, A., Innocenti, F., Colombe, S., Nerlander, L., Rachwal, N., Ciancio, B. C., Mougkou, A., Carvalho, C., Delgado, E., Mook, P., Peeters, M., Tenev, T., Golkocheva-Markova, E., Vorobieva Solholm Jensen, V., Koch, A., Figoni, J., Brouard, C., Nikolopoulou, G., ... Pebody, R. (2022). Hepatitis of unknown aetiology in children - epidemiological overview of cases reported in Europe, 1 January to 16 June 2022. Eurosurveillance, 27(31), 2200483. https://doi.org/10.2807/1560-7917.ES.2022.27.31.2200483

@article{70b74afb8108431597df9076a94f0b34,

title = "Hepatitis of unknown aetiology in children - epidemiological overview of cases reported in Europe, 1 January to 16 June 2022",

abstract = "Following the report of an excess in paediatric cases of severe acute hepatitis of unknown aetiology by the United Kingdom (UK) on 5 April 2022, 427 cases were reported from 20 countries in the World Health Organization European Region to the European Surveillance System TESSy from 1 January 2022 to 16 June 2022. Here, we analysed demographic, epidemiological, clinical and microbiological data available in TESSy. Of the reported cases, 77.3 years or younger and 53.5 10.4PCR for SARS-CoV-2 and 10.3dependency units (OR = 2.11; 95 1.18-3.74) and transplanted (OR = 3.36; 95 1.19-9.55) than cases with a negative test result for adenovirus, but this was no longer observed when looking at this association separately between the UK and other countries. Aetiological studies are needed to ascertain if adenovirus plays a role in this possible emergence of hepatitis cases in children and, if confirmed, the mechanisms that could be involved.",

keywords = "adenovirus, Child, COVID-19, Europe, hepatitis, Hepatitis A, Hospitalization, Humans, paediatric acute liver failure, SARS-CoV-2, TESSy, unknown aetiology, WHO European Region",

author = "{Roman{\'i} Vidal}, Adriana and Aisling Vaughan and Francesco Innocenti and Soledad Colombe and Lina Nerlander and Natalia Rachwal and Ciancio, {Bruno Christian} and Aikaterini Mougkou and Carlos Carvalho and Enrique Delgado and Piers Mook and Michael Peeters and Tencho Tenev and Elitsa Golkocheva-Markova and {Vorobieva Solholm Jensen}, Veronika and Anders Koch and Julie Figoni and C{\'e}cile Brouard and Georgia Nikolopoulou and Anastasia Zisouli and Niamh Murphy and Annemarie Broderick and Lital Goldberg and Rivka Rich and {Hecht Sagie}, Lior and Tosti, {Maria Elena} and Barbara Suligoi and Rosa Joosten and Roan Pijnacker and Ingvild Fjeldheim and Eli Heen and Ma{\l}gorzata St{\c e}pie{\'n} and Piotr Pola{\'n}ski and {Tato Marinho}, Rui and {Vieira Martins}, Jo{\~a}o and Carmen Varela and Ana Avell{\'o}n and Emmi Andersson and {Jansson M{\"o}rk}, Marie and Sema Mandal and Conall Watson and Laura Coughlan and Meera Chand and Claire Neill and Bradley, {Declan T.} and Kathy Li and Maureen O'Leary and Neil McInnes and Williams, {Christopher J.} and Catherine Moore and Ardiana Gjini and Erika Duffell and Richard Pebody",

year = "2022",

month = aug,

day = "1",

doi = "10.2807/1560-7917.ES.2022.27.31.2200483",

language = "English",

volume = "27",

pages = "2200483",

journal = "Eurosurveillance",

issn = "1560-7917",

publisher = "European Centre for Disease Prevention & Control",

number = "31",

}

Romaní Vidal, A, Vaughan, A, Innocenti, F, Colombe, S, Nerlander, L, Rachwal, N, Ciancio, BC, Mougkou, A, Carvalho, C, Delgado, E, Mook, P, Peeters, M, Tenev, T, Golkocheva-Markova, E, Vorobieva Solholm Jensen, V, Koch, A, Figoni, J, Brouard, C, Nikolopoulou, G, Zisouli, A, Murphy, N, Broderick, A, Goldberg, L, Rich, R, Hecht Sagie, L, Tosti, ME, Suligoi, B, Joosten, R, Pijnacker, R, Fjeldheim, I, Heen, E, Stępień, M, Polański, P, Tato Marinho, R, Vieira Martins, J, Varela, C, Avellón, A, Andersson, E, Jansson Mörk, M, Mandal, S, Watson, C, Coughlan, L, Chand, M, Neill, C, Bradley, DT, Li, K, O'Leary, M, McInnes, N, Williams, CJ, Moore, C, Gjini, A, Duffell, E & Pebody, R 2022, 'Hepatitis of unknown aetiology in children - epidemiological overview of cases reported in Europe, 1 January to 16 June 2022', Eurosurveillance, vol. 27, no. 31, pp. 2200483. https://doi.org/10.2807/1560-7917.ES.2022.27.31.2200483

TY - JOUR

T1 - Hepatitis of unknown aetiology in children - epidemiological overview of cases reported in Europe, 1 January to 16 June 2022

AU - Romaní Vidal, Adriana

AU - Vaughan, Aisling

AU - Innocenti, Francesco

AU - Colombe, Soledad

AU - Nerlander, Lina

AU - Rachwal, Natalia

AU - Ciancio, Bruno Christian

AU - Mougkou, Aikaterini

AU - Carvalho, Carlos

AU - Delgado, Enrique

AU - Mook, Piers

AU - Peeters, Michael

AU - Tenev, Tencho

AU - Golkocheva-Markova, Elitsa

AU - Vorobieva Solholm Jensen, Veronika

AU - Koch, Anders

AU - Figoni, Julie

AU - Brouard, Cécile

AU - Nikolopoulou, Georgia

AU - Zisouli, Anastasia

AU - Murphy, Niamh

AU - Broderick, Annemarie

AU - Goldberg, Lital

AU - Rich, Rivka

AU - Hecht Sagie, Lior

AU - Tosti, Maria Elena

AU - Suligoi, Barbara

AU - Joosten, Rosa

AU - Pijnacker, Roan

AU - Fjeldheim, Ingvild

AU - Heen, Eli

AU - Stępień, Małgorzata

AU - Polański, Piotr

AU - Tato Marinho, Rui

AU - Vieira Martins, João

AU - Varela, Carmen

AU - Avellón, Ana

AU - Andersson, Emmi

AU - Jansson Mörk, Marie

AU - Mandal, Sema

AU - Watson, Conall

AU - Coughlan, Laura

AU - Chand, Meera

AU - Neill, Claire

AU - Bradley, Declan T.

AU - Li, Kathy

AU - O'Leary, Maureen

AU - McInnes, Neil

AU - Williams, Christopher J.

AU - Moore, Catherine

AU - Gjini, Ardiana

AU - Duffell, Erika

AU - Pebody, Richard

PY - 2022/8/1

Y1 - 2022/8/1

N2 - Following the report of an excess in paediatric cases of severe acute hepatitis of unknown aetiology by the United Kingdom (UK) on 5 April 2022, 427 cases were reported from 20 countries in the World Health Organization European Region to the European Surveillance System TESSy from 1 January 2022 to 16 June 2022. Here, we analysed demographic, epidemiological, clinical and microbiological data available in TESSy. Of the reported cases, 77.3 years or younger and 53.5 10.4PCR for SARS-CoV-2 and 10.3dependency units (OR = 2.11; 95 1.18-3.74) and transplanted (OR = 3.36; 95 1.19-9.55) than cases with a negative test result for adenovirus, but this was no longer observed when looking at this association separately between the UK and other countries. Aetiological studies are needed to ascertain if adenovirus plays a role in this possible emergence of hepatitis cases in children and, if confirmed, the mechanisms that could be involved.

AB - Following the report of an excess in paediatric cases of severe acute hepatitis of unknown aetiology by the United Kingdom (UK) on 5 April 2022, 427 cases were reported from 20 countries in the World Health Organization European Region to the European Surveillance System TESSy from 1 January 2022 to 16 June 2022. Here, we analysed demographic, epidemiological, clinical and microbiological data available in TESSy. Of the reported cases, 77.3 years or younger and 53.5 10.4PCR for SARS-CoV-2 and 10.3dependency units (OR = 2.11; 95 1.18-3.74) and transplanted (OR = 3.36; 95 1.19-9.55) than cases with a negative test result for adenovirus, but this was no longer observed when looking at this association separately between the UK and other countries. Aetiological studies are needed to ascertain if adenovirus plays a role in this possible emergence of hepatitis cases in children and, if confirmed, the mechanisms that could be involved.

KW - adenovirus

KW - Child

KW - COVID-19

KW - Europe

KW - hepatitis

KW - Hepatitis A

KW - Hospitalization

KW - Humans

KW - paediatric acute liver failure

KW - SARS-CoV-2

KW - TESSy

KW - unknown aetiology

KW - WHO European Region

U2 - 10.2807/1560-7917.ES.2022.27.31.2200483

DO - 10.2807/1560-7917.ES.2022.27.31.2200483

M3 - Article

SN - 1560-7917

VL - 27

SP - 2200483

JO - Eurosurveillance

JF - Eurosurveillance

IS - 31

ER -

Hepatitis of unknown aetiology in children - epidemiological overview of cases reported in Europe, 1 January to 16 June 2022

Abstract

Keywords

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