Het gebruik van antivirale middelen tijdens een (dreigende) influenzapandemie

Translated title of the contribution: The use of antiviral agents during an (impending) influenza pandemic

W Opstelten, J E van Steenbergen, G A van Essen, Marianne Van der Sande

Research output: Contribution to journalReviewpeer-review


The preventive and therapeutic principles during an (impending) influenza pandemic differ fundamentally from those prevailing during the annual episodes ofinfluenza. Pending the availability of an effective pandemic vaccine, neuraminidase inhibitors are the only effective agents for the prevention and treatment of infections caused by a pandemic influenza virus. The development of an influenza pandemic has 6 phases: phases 3-5 reflect an increasing threat; phase 6 represents a manifest pandemic. During phases 3-5, a maximum effort is made to prevent or delay a pandemic. Neuraminidase inhibitors should be given not only to patients but also to their close contacts (post-exposure prophylaxis). During phase 6, post-exposure prophylaxis is no longer indicated and neuraminidase inhibitors are prescribed for all patients with symptoms ofpandemic influenza. Prophylaxis without preceding close contact with an influenza patient (primary prophylaxis) is recommended only in exceptional cases. Physicians should not prescribe antiviral drugs on demand to concerned citizens for stockpiling.

Translated title of the contributionThe use of antiviral agents during an (impending) influenza pandemic
Original languageDutch
JournalNederlands Tijdschrift voor Geneeskunde
Issue number18
Pages (from-to)1008-1012
Number of pages5
Publication statusPublished - 2007


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