Heterosexual transmission of HIV-1 among employees and their spouses at two large businesses in Zaire

RW Ryder, N Mibandumba, SE Hassig, K Munkolenkole, D Sequeira, K Mwandagalirwa, H Francis, F Behets, RL Colebunders, A Dopagne, R Kambale, WL Heyward

    Research output: Contribution to journalA1: Web of Science-article

    Abstract

    To better understand the reasons why up to 80% of all HIV-1 infections in Zaire, but less than 5% in North America and Europe, are acquired through heterosexual transmission, and to assess the impact of HIV-1 infection on a large urban African workforce, we enrolled 7068 male employees, 416 female employees and 4548 female spouses of employees at two large Kinshasa businesses (a textile factory and a commercial bank) in a prospective study of HIV-1 infection. The HIV-1 seroprevalence rate was higher in male employees (5.8%) and their spouses (5.7%) at the bank than among male employees (2.8%) and their spouses (3.3%) at the textile factory. At both businesses HIV-1 seroprevalence was higher among employees in managerial positions (5.0%) than among workers in lower-level positions (3.0%; P less than 0.0001). In a multivariate analysis of male employees, receipt of a transfusion, a history of genital ulcer disease, working at the bank, urethritis, or being divorced or separated were independently associated with HIV-1 infection. During 1987 and 1988, AIDS was the most common cause of death among recently employed workers, accounting for 20 and 24% of all deaths at the textile factory and the commercial bank, respectively. The HIV-1 seroprevalence rate was higher among female workers (7.7%) than among the spouses of male workers (3.9%; P = 0.001). In multivariate analysis of the wives of workers, having an HIV-1-seropositive spouse, receipt of a blood transfusion, or a history of genital ulcer disease were independently associated with HIV-1 infection. (ABSTRACT TRUNCATED AT 250 WORDS)
    Original languageEnglish
    JournalAIDS
    Volume4
    Pages (from-to)725-732
    ISSN0269-9370
    Publication statusPublished - 1990

    Keywords

    • B780-tropical-medicine
    • Viral diseases
    • AIDS
    • HIV
    • STD
    • Sexually transmitted diseases
    • Industry
    • Employees
    • Risk
    • Congo-Kinshasa
    • Africa-Central

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