HIV Nef: role in pathogenesis and viral fitness

Kevin Ariën, Bruno Verhasselt

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Conserved in all primate lentivirus genomes, Nef promotes viral replication and infectivity, influences the trafficking of a large number of surface receptors and interferes with TCR signalling, consequently modulating T-cell activation. In vivo observations with Long Term Non-Progressors harbouring a Nef-defective HIV and vaccination studies with Nef-deleted SIV in Rhesus macaques have shown a prominent role for Nef in lentiviral pathogenesis. Here we review the functions of Nef involved in viral replication and infectivity and speculate on a possible role for Nef in HIV fitness.

Original languageEnglish
JournalCurrent HIV Research
Issue number3
Pages (from-to)200-8
Number of pages9
Publication statusPublished - May-2008
Externally publishedYes


  • Amino Acid Sequence
  • Animals
  • CD4-Positive T-Lymphocytes
  • HIV Infections
  • HIV-1
  • HIV-2
  • Humans
  • Macaca mulatta
  • Molecular Sequence Data
  • Receptors, HIV
  • Sequence Alignment
  • Simian immunodeficiency virus
  • Virus Replication
  • nef Gene Products, Human Immunodeficiency Virus

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