HIV sexual transmission and microbicides

KK Ariën, V Jespers, G Vanham

    Research output: Contribution to journalA1: Web of Science-article

    Abstract

    Pathogens often rely on the contacts between hosts for transmission. Most viruses have adapted their transmission mechanisms to defined behaviours of their host(s) and have learned to exploit these for their own propagation. Some viruses, such as HIV, the human papillomavirus (HPV), HSV-2 and HCV, cause sexually transmitted infections (STIs). Understanding the transmission of particular viral variants and comprehending the early adaptation and evolution is fundamental to eventually inhibiting sexual transmission of HIV. Here, we review the current understanding of the mechanisms of sexual transmission and the biology of the transmitted HIV. Next, we present a timely overview of candidate microbicides, including past, ongoing and future clinical trials of HIV topical microbicides. Copyright (c) 2011 John Wiley & Sons, Ltd.
    Original languageEnglish
    JournalReviews in Medical Virology
    Volume21
    Issue number2
    Pages (from-to)110-133
    Number of pages24
    ISSN1052-9276
    DOIs
    Publication statusPublished - 2011

    Keywords

    • B780-tropical-medicine
    • Viral diseases
    • HIV
    • AIDS
    • Disease transmission-sexual
    • Risk
    • Genital tract
    • Women
    • Men
    • Natural resistance
    • Prevention strategies
    • Male circumcision
    • Microbicides
    • Behavior
    • Condom use
    • Vaccination
    • Vaginal creams and foams
    • Vaginal gel
    • Inhibitory activity
    • Reverse transcriptase inhibitors
    • Integrase inhibitors
    • Protease inhibitors
    • Clinical trials
    • Oral
    • Pre-exposure
    • Prophylaxis
    • Development
    • Review of the literature

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