HPV seroconversion following anal and penile HPV infection in HIV-negative and HIV-infected MSM

Sofie H Mooij; Olivia Landén; Fiona R M van der Klis; Marianne A B van der Sande; Hester E de Melker; Maria Xiridou; Arne van Eeden; Titia Heijman; Arjen G C L Speksnijder; Peter J F Snijders; Maarten F Schim van der Loeff

doi:10.1158/1055-9965.EPI-14-0199

HPV seroconversion following anal and penile HPV infection in HIV-negative and HIV-infected MSM

Sofie H Mooij, Olivia Landén, Fiona R M van der Klis, Marianne A B van der Sande, Hester E de Melker, Maria Xiridou, Arne van Eeden, Titia Heijman, Arjen G C L Speksnijder, Peter J F Snijders, Maarten F Schim van der Loeff

Department of Public Health

Research output: Contribution to journal › A1: Web of Science-article › peer-review

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Abstract

BACKGROUND: We assessed human papillomavirus (HPV) seroconversion following anal and penile HPV infection in HIV-negative and HIV-infected men who have sex with men (MSM).

METHODS: MSM aged ≥18 years were recruited in Amsterdam, the Netherlands (2010-2011), and followed up semiannually. Antibodies against 7 high-risk HPV types in baseline and 12-month serum samples were tested using a multiplex immunoassay. Baseline, 6-, and 12-month anal and penile samples were tested for HPV DNA using the SPF10-PCR DEIA/LiPA25 system. Statistical analyses were performed using logistic regression with generalized estimating equations.

RESULTS: Of 644 MSM included in the analysis, 245 (38%) were HIV-infected. Median age was 38 years for HIV-negative and 47 years for HIV-infected MSM (P < 0.001). Seroconversion against ≥1 of the 7 HPV types was observed in 74 of 396 (19%) HIV-negative and 52 of 223 (23%) HIV-infected MSM at risk (P = 0.2). Incident [adjusted OR (aOR) 2.0; 95% confidence interval (CI), 1.1-3.4] and persistent (aOR 3.7; 95% CI, 1.5-9.5) anal HPV infections were independently associated with type-specific seroconversion in HIV-negative MSM. In HIV-infected MSM, there was a nonsignificant positive association between penile HPV infection at any time point and seroconversion (aOR 1.7; 95% CI, 0.9-3.2).

CONCLUSIONS: Incident or persistent anal HPV infection was an independent determinant of seroconversion in HIV-negative MSM.

IMPACT: Our data support that seroresponse may vary per anatomic site and that persistent HPV infections are more likely to elicit a detectable humoral immune response.

Original language	English
Journal	Cancer Epidemiology, Biomarkers & Prevention
Volume	23
Issue number	11
Pages (from-to)	2455-2461
Number of pages	7
ISSN	1055-9965
DOIs	https://doi.org/10.1158/1055-9965.EPI-14-0199
Publication status	Published - 2014

Keywords

Adult
Anal Canal/virology
HIV Infections/virology
Homosexuality, Male
Humans
Male
Papillomaviridae/genetics
Papillomavirus Infections/virology
Penis/virology
Risk Factors

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Mooij, S. H., Landén, O., van der Klis, F. R. M., van der Sande, M. A. B., de Melker, H. E., Xiridou, M., van Eeden, A., Heijman, T., Speksnijder, A. G. C. L., Snijders, P. J. F., & Schim van der Loeff, M. F. (2014). HPV seroconversion following anal and penile HPV infection in HIV-negative and HIV-infected MSM. Cancer Epidemiology, Biomarkers & Prevention, 23(11), 2455-2461. https://doi.org/10.1158/1055-9965.EPI-14-0199

@article{f7697105a8424abdada046bae89b6421,

title = "HPV seroconversion following anal and penile HPV infection in HIV-negative and HIV-infected MSM",

abstract = "BACKGROUND: We assessed human papillomavirus (HPV) seroconversion following anal and penile HPV infection in HIV-negative and HIV-infected men who have sex with men (MSM).METHODS: MSM aged ≥18 years were recruited in Amsterdam, the Netherlands (2010-2011), and followed up semiannually. Antibodies against 7 high-risk HPV types in baseline and 12-month serum samples were tested using a multiplex immunoassay. Baseline, 6-, and 12-month anal and penile samples were tested for HPV DNA using the SPF10-PCR DEIA/LiPA25 system. Statistical analyses were performed using logistic regression with generalized estimating equations.RESULTS: Of 644 MSM included in the analysis, 245 (38%) were HIV-infected. Median age was 38 years for HIV-negative and 47 years for HIV-infected MSM (P < 0.001). Seroconversion against ≥1 of the 7 HPV types was observed in 74 of 396 (19%) HIV-negative and 52 of 223 (23%) HIV-infected MSM at risk (P = 0.2). Incident [adjusted OR (aOR) 2.0; 95% confidence interval (CI), 1.1-3.4] and persistent (aOR 3.7; 95% CI, 1.5-9.5) anal HPV infections were independently associated with type-specific seroconversion in HIV-negative MSM. In HIV-infected MSM, there was a nonsignificant positive association between penile HPV infection at any time point and seroconversion (aOR 1.7; 95% CI, 0.9-3.2).CONCLUSIONS: Incident or persistent anal HPV infection was an independent determinant of seroconversion in HIV-negative MSM.IMPACT: Our data support that seroresponse may vary per anatomic site and that persistent HPV infections are more likely to elicit a detectable humoral immune response.",

keywords = "Adult, Anal Canal/virology, HIV Infections/virology, Homosexuality, Male, Humans, Male, Papillomaviridae/genetics, Papillomavirus Infections/virology, Penis/virology, Risk Factors",

author = "Mooij, {Sofie H} and Olivia Land{\'e}n and {van der Klis}, {Fiona R M} and {van der Sande}, {Marianne A B} and {de Melker}, {Hester E} and Maria Xiridou and {van Eeden}, Arne and Titia Heijman and Speksnijder, {Arjen G C L} and Snijders, {Peter J F} and {Schim van der Loeff}, {Maarten F}",

note = "FTX; {\textcopyright}2014 American Association for Cancer Research.",

year = "2014",

doi = "10.1158/1055-9965.EPI-14-0199",

language = "English",

volume = "23",

pages = "2455--2461",

journal = "Cancer Epidemiology, Biomarkers & Prevention",

issn = "1055-9965",

publisher = "American Association for Cancer Research Inc.",

number = "11",

}

Mooij, SH, Landén, O, van der Klis, FRM, van der Sande, MAB, de Melker, HE, Xiridou, M, van Eeden, A, Heijman, T, Speksnijder, AGCL, Snijders, PJF & Schim van der Loeff, MF 2014, 'HPV seroconversion following anal and penile HPV infection in HIV-negative and HIV-infected MSM', Cancer Epidemiology, Biomarkers & Prevention, vol. 23, no. 11, pp. 2455-2461. https://doi.org/10.1158/1055-9965.EPI-14-0199

TY - JOUR

T1 - HPV seroconversion following anal and penile HPV infection in HIV-negative and HIV-infected MSM

AU - Mooij, Sofie H

AU - Landén, Olivia

AU - van der Klis, Fiona R M

AU - van der Sande, Marianne A B

AU - de Melker, Hester E

AU - Xiridou, Maria

AU - van Eeden, Arne

AU - Heijman, Titia

AU - Speksnijder, Arjen G C L

AU - Snijders, Peter J F

AU - Schim van der Loeff, Maarten F

PY - 2014

Y1 - 2014

N2 - BACKGROUND: We assessed human papillomavirus (HPV) seroconversion following anal and penile HPV infection in HIV-negative and HIV-infected men who have sex with men (MSM).METHODS: MSM aged ≥18 years were recruited in Amsterdam, the Netherlands (2010-2011), and followed up semiannually. Antibodies against 7 high-risk HPV types in baseline and 12-month serum samples were tested using a multiplex immunoassay. Baseline, 6-, and 12-month anal and penile samples were tested for HPV DNA using the SPF10-PCR DEIA/LiPA25 system. Statistical analyses were performed using logistic regression with generalized estimating equations.RESULTS: Of 644 MSM included in the analysis, 245 (38%) were HIV-infected. Median age was 38 years for HIV-negative and 47 years for HIV-infected MSM (P < 0.001). Seroconversion against ≥1 of the 7 HPV types was observed in 74 of 396 (19%) HIV-negative and 52 of 223 (23%) HIV-infected MSM at risk (P = 0.2). Incident [adjusted OR (aOR) 2.0; 95% confidence interval (CI), 1.1-3.4] and persistent (aOR 3.7; 95% CI, 1.5-9.5) anal HPV infections were independently associated with type-specific seroconversion in HIV-negative MSM. In HIV-infected MSM, there was a nonsignificant positive association between penile HPV infection at any time point and seroconversion (aOR 1.7; 95% CI, 0.9-3.2).CONCLUSIONS: Incident or persistent anal HPV infection was an independent determinant of seroconversion in HIV-negative MSM.IMPACT: Our data support that seroresponse may vary per anatomic site and that persistent HPV infections are more likely to elicit a detectable humoral immune response.

AB - BACKGROUND: We assessed human papillomavirus (HPV) seroconversion following anal and penile HPV infection in HIV-negative and HIV-infected men who have sex with men (MSM).METHODS: MSM aged ≥18 years were recruited in Amsterdam, the Netherlands (2010-2011), and followed up semiannually. Antibodies against 7 high-risk HPV types in baseline and 12-month serum samples were tested using a multiplex immunoassay. Baseline, 6-, and 12-month anal and penile samples were tested for HPV DNA using the SPF10-PCR DEIA/LiPA25 system. Statistical analyses were performed using logistic regression with generalized estimating equations.RESULTS: Of 644 MSM included in the analysis, 245 (38%) were HIV-infected. Median age was 38 years for HIV-negative and 47 years for HIV-infected MSM (P < 0.001). Seroconversion against ≥1 of the 7 HPV types was observed in 74 of 396 (19%) HIV-negative and 52 of 223 (23%) HIV-infected MSM at risk (P = 0.2). Incident [adjusted OR (aOR) 2.0; 95% confidence interval (CI), 1.1-3.4] and persistent (aOR 3.7; 95% CI, 1.5-9.5) anal HPV infections were independently associated with type-specific seroconversion in HIV-negative MSM. In HIV-infected MSM, there was a nonsignificant positive association between penile HPV infection at any time point and seroconversion (aOR 1.7; 95% CI, 0.9-3.2).CONCLUSIONS: Incident or persistent anal HPV infection was an independent determinant of seroconversion in HIV-negative MSM.IMPACT: Our data support that seroresponse may vary per anatomic site and that persistent HPV infections are more likely to elicit a detectable humoral immune response.

KW - Adult

KW - Anal Canal/virology

KW - HIV Infections/virology

KW - Homosexuality, Male

KW - Humans

KW - Male

KW - Papillomaviridae/genetics

KW - Papillomavirus Infections/virology

KW - Penis/virology

KW - Risk Factors

U2 - 10.1158/1055-9965.EPI-14-0199

DO - 10.1158/1055-9965.EPI-14-0199

M3 - A1: Web of Science-article

C2 - 25169974

SN - 1055-9965

VL - 23

SP - 2455

EP - 2461

JO - Cancer Epidemiology, Biomarkers & Prevention

JF - Cancer Epidemiology, Biomarkers & Prevention

IS - 11

ER -

HPV seroconversion following anal and penile HPV infection in HIV-negative and HIV-infected MSM

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