Human immunodeficiency virus seroprevalence in pediatric patients 2 to 14 years of age at Mama Yemo Hospital, Kinshasa, Zaire

JM Mann, H Francis, F Davachi, P Baudoux, TC Quinn, N Nzilambi, B Ngaly, RL Colebunders, N Kabote, P Piot, KA Pangu, JW Curran

    Research output: Contribution to journalA2: International peer reviewed article (not A1-type)

    Abstract

    Seroprevalence to human immunodeficiency virus (HIV) was determined among 368 children 2 to 14 years of age who were admitted to the pediatric service at Mama Yemo Hospital in Kinshasa, Zaire. Forty (11%) of these patients and only one (1%) of 92 healthy siblings of these patients were HIV seropositive (chi 2 = 8.68, P less than. 01). Seropositivity was associated with previous hospitalization, receipt of a blood transfusion prior to the current hospitalization (odds ratio 3.1; 95% confidence interval, 1.5 to 6.4), receipt of medical injections during the past year, and smaller household size. Clinically, HIV seropositivity was associated with the diagnoses of malnutrition and pneumonia. A higher proportion of seropositive children died during the current hospitalization (4/40 v 10/328); when patients with malaria were excluded, the in-hospital mortality of seropositive children was more than eight times higher than that of seronegative children (Fisher exact test, P =. 006). Clarification of clinical, immunologic, and epidemiologic features of childhood HIV infection is urgently required because HIV appears to account for or complicate a substantial proportion of pediatric hospitalizations in Kinshasa
    Original languageEnglish
    JournalPediatrics
    Volume78
    Pages (from-to)673-677
    ISSN0031-4005
    Publication statusPublished - 1986

    Keywords

    • B780-tropical-medicine
    • Viral diseases
    • HIV
    • Antibodies
    • HTLV
    • Immunology
    • AIDS
    • Epidemiology
    • Blood transfusion
    • Adverse effects
    • Children
    • Risk
    • Kinshasa
    • Congo-Kinshasa
    • Africa-Central

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