Hyperendemicity of cysticercosis in Madagascar: novel insights from school children population-based antigen prevalence study

Jean-François Carod, Frédéric Mauny, Anne Laure Parmentier, Maxime Desmarets, Mahenintsoa Rakotondrazaka, Alice Brembilla, Véronique Dermauw, Julien Razafimahefa, Rondro Mamitiana Ramahefarisoa, Marcellin Andriantseheno, Sarah Bailly, Didier Ménard, Pierre Dorny

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    Abstract

    OBJECTIVE: Taenia solium (Ts) cysticercosis is a neglected zoonotic disease particularly prevalent in Madagascar. Few data are available for children, current data mainly rely on antibody prevalence. We sought to determine the Ts-antigen seroprevalence-determining active cysticercosis-amongst school children from various cities in Madagascar (excluding the capital) and evaluated associated risk factors.

    METHODS: In seven cities in Madagascar, the presence of cysticercosis in school children (n = 1751) was investigated in 2007 using the B158/B60 antigen (Ag)-ELISA.

    RESULTS: The overall prevalence based on Ag detection was 27.7% [95%CI: 10-37%]. Risk factors associated with Ag positivity were age, biotope, altitude and annual average rainfall.

    CONCLUSION: These results highlight the high prevalence of active cysticercosis in Madagascar among school children in an urban setting. This high prevalence as well as the risk factors unraveled point to the emergency to implement appropriate Public Health measure son a national scale.

    Original languageEnglish
    Article numbere0258035
    JournalPLoS ONE
    Volume16
    Issue number10
    Number of pages11
    ISSN1932-6203
    DOIs
    Publication statusPublished - 2021

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