TY - JOUR
T1 - Hyperendemicity of cysticercosis in Madagascar: novel insights from school children population-based antigen prevalence study
AU - Carod, Jean-François
AU - Mauny, Frédéric
AU - Parmentier, Anne Laure
AU - Desmarets, Maxime
AU - Rakotondrazaka, Mahenintsoa
AU - Brembilla, Alice
AU - Dermauw, Véronique
AU - Razafimahefa, Julien
AU - Ramahefarisoa, Rondro Mamitiana
AU - Andriantseheno, Marcellin
AU - Bailly, Sarah
AU - Ménard, Didier
AU - Dorny, Pierre
N1 - FTX; DOAJ; (CC BY 4.0)
PY - 2021
Y1 - 2021
N2 - OBJECTIVE: Taenia solium (Ts) cysticercosis is a neglected zoonotic disease particularly prevalent in Madagascar. Few data are available for children, current data mainly rely on antibody prevalence. We sought to determine the Ts-antigen seroprevalence-determining active cysticercosis-amongst school children from various cities in Madagascar (excluding the capital) and evaluated associated risk factors.METHODS: In seven cities in Madagascar, the presence of cysticercosis in school children (n = 1751) was investigated in 2007 using the B158/B60 antigen (Ag)-ELISA.RESULTS: The overall prevalence based on Ag detection was 27.7% [95%CI: 10-37%]. Risk factors associated with Ag positivity were age, biotope, altitude and annual average rainfall.CONCLUSION: These results highlight the high prevalence of active cysticercosis in Madagascar among school children in an urban setting. This high prevalence as well as the risk factors unraveled point to the emergency to implement appropriate Public Health measure son a national scale.
AB - OBJECTIVE: Taenia solium (Ts) cysticercosis is a neglected zoonotic disease particularly prevalent in Madagascar. Few data are available for children, current data mainly rely on antibody prevalence. We sought to determine the Ts-antigen seroprevalence-determining active cysticercosis-amongst school children from various cities in Madagascar (excluding the capital) and evaluated associated risk factors.METHODS: In seven cities in Madagascar, the presence of cysticercosis in school children (n = 1751) was investigated in 2007 using the B158/B60 antigen (Ag)-ELISA.RESULTS: The overall prevalence based on Ag detection was 27.7% [95%CI: 10-37%]. Risk factors associated with Ag positivity were age, biotope, altitude and annual average rainfall.CONCLUSION: These results highlight the high prevalence of active cysticercosis in Madagascar among school children in an urban setting. This high prevalence as well as the risk factors unraveled point to the emergency to implement appropriate Public Health measure son a national scale.
U2 - 10.1371/journal.pone.0258035
DO - 10.1371/journal.pone.0258035
M3 - A1: Web of Science-article
C2 - 34597322
SN - 1932-6203
VL - 16
JO - PLoS ONE
JF - PLoS ONE
IS - 10
M1 - e0258035
ER -