Hyperlactatemia and concurrent use of antiretroviral therapy among HIV infected patients in Uganda

M. Waiswa, B. Byarugaba, P. Ocama, H. Mayanja-Kizza, E. Seremba, S. Ganguli, M. Crowther, R. Colebunders

    Research output: Contribution to journalA1: Web of Science-article

    Abstract

    BACKGROUND: We determined the prevalence and factors associated with hyperlactatemia among HIV patients admitted on the emergency ward of a national hospital in Uganda. OBJECTIVE: We were specifically interested in knowing whether there was an association between clinically significant hyperlactatemia and concurrent antiretroviral therapy (ART) use. METHODS: A cross sectional descriptive study enrolled 303 HIV infected patients at a national referral hospital between March and April 2008. We consecutively recruited all eligible HIV infected patients above 18 years admitted on the emergency ward. Data were collected on socio-demographic, clinical and laboratory characteristics. Lactate levels were measured using the Accutrend(R) portable lactate analyser. Data analysis was performed using Stata 10.0; P-value of <0.05 was considered to be significant. RESULTS: Three hundred and three HIV infected patients were recruited. Prevalence of hyperlactatemia (lactate >/=2.5mmol/L) was 252 (83.2%). Clinically significant hyperlactatemia (lactate >/=4mmol/L) was present in 105/303(34.6%) patients. There was no association between use of ART and clinically significant hyperlactatemia. In the multivariate analysis, body weakness 1.91 (1.09-3.35), skin rash 3.18 (1.11-9.10) and tachypnoea 1.04 (1.01-1.07) were independently associated with clinically significant hyperlactatemia. CONCLUSION: There was a high prevalence of clinically significant hyperlactatemia among HIV infected patients but it was not associated with concurrent antiretroviral use.
    Original languageEnglish
    JournalAfrican Health Sciences
    Volume12
    Issue number3
    Pages (from-to)268-275
    Number of pages8
    ISSN1680-6905
    DOIs
    Publication statusPublished - 2012

    Keywords

    • Viral diseases
    • HIV
    • AIDS
    • HAART
    • Antiretrovirals
    • Prevalence
    • Risk factors
    • Associations
    • Hyperlactatemia
    • Emergency care
    • Hospitalization
    • Predictors
    • Body weakness
    • Tachypnoea
    • Rashes
    • Uganda
    • Africa-East

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