Immune trypanolysis test as a promising bioassay to monitor the elimination of gambiense human African trypanosomiasis

Emilie Dama; Oumou Camara; Dramane Kaba; Mathurin Koffi; Mamadou Camara; Charlie Compaore; Hamidou Ilboudo; Fabrice Courtin; Jacques Kabore; Emmanuel Kouassi N'Gouan; Philippe Büscher; Veerle Lejon; Bruno Bucheton; Vincent Jamonneau

doi:10.1051/parasite/2019066

Immune trypanolysis test as a promising bioassay to monitor the elimination of gambiense human African trypanosomiasis

Emilie Dama, Oumou Camara, Dramane Kaba, Mathurin Koffi, Mamadou Camara, Charlie Compaore, Hamidou Ilboudo, Fabrice Courtin, Jacques Kabore, Emmanuel Kouassi N'Gouan, Philippe Büscher, Veerle Lejon, Bruno Bucheton, Vincent Jamonneau

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Abstract

The World Health Organization (WHO) has set the goal of gambiense-Human African trypanosomiasis (HAT) elimination as a public health problem for 2020 and interruption of transmission in humans for 2030. In this context, it is crucial to monitor progress towards these targets using accurate tools to assess the level of transmission in a given area. The aim of this study was to investigate the relevance of the immune trypanolysis test (TL) as a population-based bioassay to evaluate Trypanosoma brucei gambiense transmission in various epidemiological contexts. Significant correlations were observed between HAT endemicity levels and the percentage of TL-positive individuals in the population. TL therefore appears to be a suitable population-based biomarker of the intensity of transmission. In addition to being used as a tool to assess the HAT status at an individual level, assessing the proportion of TL positive individuals in the population appears as a promising and easy alternative to monitor the elimination of gambiense HAT in a given area.

Original language	English
Article number	68
Journal	Parasite
Volume	26
Number of pages	7
ISSN	1252-607X
DOIs	https://doi.org/10.1051/parasite/2019066
Publication status	Published - 2019

Keywords

Human African Trypanosomiasis
Trypanosoma brucei gambiense
Elimination
Diagnosis
Transmission
Immune trypanolysis
GLOSSINA-PALPALIS-GAMBIENSIS
SLEEPING SICKNESS
BRUCEI-GAMBIENSE
IVORY-COAST
COTE-DIVOIRE
DIAGNOSIS
CATT
SERODIAGNOSIS
SURVEILLANCE
SENSITIVITY

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10.1051/parasite/2019066Licence: CC BY

2019para0068Final published version, 474 KBLicence: CC BY

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Dama, E., Camara, O., Kaba, D., Koffi, M., Camara, M., Compaore, C., Ilboudo, H., Courtin, F., Kabore, J., N'Gouan, E. K., Büscher, P., Lejon, V., Bucheton, B., & Jamonneau, V. (2019). Immune trypanolysis test as a promising bioassay to monitor the elimination of gambiense human African trypanosomiasis. Parasite, 26, Article 68. https://doi.org/10.1051/parasite/2019066

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abstract = "The World Health Organization (WHO) has set the goal of gambiense-Human African trypanosomiasis (HAT) elimination as a public health problem for 2020 and interruption of transmission in humans for 2030. In this context, it is crucial to monitor progress towards these targets using accurate tools to assess the level of transmission in a given area. The aim of this study was to investigate the relevance of the immune trypanolysis test (TL) as a population-based bioassay to evaluate Trypanosoma brucei gambiense transmission in various epidemiological contexts. Significant correlations were observed between HAT endemicity levels and the percentage of TL-positive individuals in the population. TL therefore appears to be a suitable population-based biomarker of the intensity of transmission. In addition to being used as a tool to assess the HAT status at an individual level, assessing the proportion of TL positive individuals in the population appears as a promising and easy alternative to monitor the elimination of gambiense HAT in a given area.",

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AU - Dama, Emilie

AU - Camara, Oumou

AU - Kaba, Dramane

AU - Koffi, Mathurin

AU - Camara, Mamadou

AU - Compaore, Charlie

AU - Ilboudo, Hamidou

AU - Courtin, Fabrice

AU - Kabore, Jacques

AU - N'Gouan, Emmanuel Kouassi

AU - Büscher, Philippe

AU - Lejon, Veerle

AU - Bucheton, Bruno

AU - Jamonneau, Vincent

N1 - FTX; DOAJ; (CC BY 4.0)

PY - 2019

Y1 - 2019

N2 - The World Health Organization (WHO) has set the goal of gambiense-Human African trypanosomiasis (HAT) elimination as a public health problem for 2020 and interruption of transmission in humans for 2030. In this context, it is crucial to monitor progress towards these targets using accurate tools to assess the level of transmission in a given area. The aim of this study was to investigate the relevance of the immune trypanolysis test (TL) as a population-based bioassay to evaluate Trypanosoma brucei gambiense transmission in various epidemiological contexts. Significant correlations were observed between HAT endemicity levels and the percentage of TL-positive individuals in the population. TL therefore appears to be a suitable population-based biomarker of the intensity of transmission. In addition to being used as a tool to assess the HAT status at an individual level, assessing the proportion of TL positive individuals in the population appears as a promising and easy alternative to monitor the elimination of gambiense HAT in a given area.

AB - The World Health Organization (WHO) has set the goal of gambiense-Human African trypanosomiasis (HAT) elimination as a public health problem for 2020 and interruption of transmission in humans for 2030. In this context, it is crucial to monitor progress towards these targets using accurate tools to assess the level of transmission in a given area. The aim of this study was to investigate the relevance of the immune trypanolysis test (TL) as a population-based bioassay to evaluate Trypanosoma brucei gambiense transmission in various epidemiological contexts. Significant correlations were observed between HAT endemicity levels and the percentage of TL-positive individuals in the population. TL therefore appears to be a suitable population-based biomarker of the intensity of transmission. In addition to being used as a tool to assess the HAT status at an individual level, assessing the proportion of TL positive individuals in the population appears as a promising and easy alternative to monitor the elimination of gambiense HAT in a given area.

KW - Human African Trypanosomiasis

KW - Trypanosoma brucei gambiense

KW - Elimination

KW - Diagnosis

KW - Transmission

KW - Immune trypanolysis

KW - GLOSSINA-PALPALIS-GAMBIENSIS

KW - SLEEPING SICKNESS

KW - BRUCEI-GAMBIENSE

KW - IVORY-COAST

KW - COTE-DIVOIRE

KW - DIAGNOSIS

KW - CATT

KW - SERODIAGNOSIS

KW - SURVEILLANCE

KW - SENSITIVITY

U2 - 10.1051/parasite/2019066

DO - 10.1051/parasite/2019066

M3 - A1: Web of Science-article

SN - 1252-607X

VL - 26

JO - Parasite

JF - Parasite

M1 - 68

ER -

Immune trypanolysis test as a promising bioassay to monitor the elimination of gambiense human African trypanosomiasis

Abstract

Keywords

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