Immunoglobulins against the surface of Plasmodium falciparum-infected erythrocytes increase one month after delivery

Alfredo Mayor; Elisa Serra-Casas; Eduard Rovira-Vallbona; Alfons Jiménez; Llorenç Quintó; Betuel Sigaúque; Carlota Dobaño; Azucena Bardají; Pedro L Alonso; Clara Menéndez

doi:10.1186/1475-2875-11-130

Immunoglobulins against the surface of Plasmodium falciparum-infected erythrocytes increase one month after delivery

Alfredo Mayor, Elisa Serra-Casas, Eduard Rovira-Vallbona, Alfons Jiménez, Llorenç Quintó, Betuel Sigaúque, Carlota Dobaño, Azucena Bardají, Pedro L Alonso, Clara Menéndez

Research output: Contribution to journal › A1: Web of Science-article › peer-review

Abstract

BACKGROUND: The risk of Plasmodium falciparum malaria increases during pregnancy and at early postpartum. Immunological and physiological alterations associated with pregnancy that persist after delivery may contribute to the susceptibility to P. falciparum during early postpartum period.

METHODS: To determine changes in antibody-mediated responses after pregnancy, levels of Immunoglobulin G (IgGs) specific for P. falciparum were compared in 200 pairs of plasmas collected from Mozambican women at delivery and during the first two months postpartum. IgGs against the surface of erythrocytes infected with a P. falciparum chondroitin sulphate A binding line (CS2) and a paediatric isolate (MOZ2) were measured by flow cytometry.

RESULTS: IgG levels against CS2 and MOZ2 were higher at postpartum than at delivery (p = 0.033 and p = 0.045, respectively) in women without P. falciparum infection. The analysis stratified by parity and period after delivery showed that this increase was significant in multi-gravid women (p = 0.023 for CS2 and p = 0.054 for MOZ2) and during the second month after delivery (p = 0.018 for CS2 and p = 0.015 for MOZ2).

CONCLUSIONS: These results support the view that early postpartum is a period of recovery from physiological or immunological changes associated with pregnancy.

Original language	English
Journal	Malaria Journal
Volume	11
Pages (from-to)	130
ISSN	1475-2875
DOIs	https://doi.org/10.1186/1475-2875-11-130
Publication status	Published - 2012
Externally published	Yes

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@article{1584bb8a40524136aab82bb108fa85a3,

title = "Immunoglobulins against the surface of Plasmodium falciparum-infected erythrocytes increase one month after delivery",

abstract = "BACKGROUND: The risk of Plasmodium falciparum malaria increases during pregnancy and at early postpartum. Immunological and physiological alterations associated with pregnancy that persist after delivery may contribute to the susceptibility to P. falciparum during early postpartum period.METHODS: To determine changes in antibody-mediated responses after pregnancy, levels of Immunoglobulin G (IgGs) specific for P. falciparum were compared in 200 pairs of plasmas collected from Mozambican women at delivery and during the first two months postpartum. IgGs against the surface of erythrocytes infected with a P. falciparum chondroitin sulphate A binding line (CS2) and a paediatric isolate (MOZ2) were measured by flow cytometry.RESULTS: IgG levels against CS2 and MOZ2 were higher at postpartum than at delivery (p = 0.033 and p = 0.045, respectively) in women without P. falciparum infection. The analysis stratified by parity and period after delivery showed that this increase was significant in multi-gravid women (p = 0.023 for CS2 and p = 0.054 for MOZ2) and during the second month after delivery (p = 0.018 for CS2 and p = 0.015 for MOZ2).CONCLUSIONS: These results support the view that early postpartum is a period of recovery from physiological or immunological changes associated with pregnancy.",

keywords = "Adult, Antibodies, Protozoan, Erythrocytes, Female, Flow Cytometry, Humans, Immunoglobulin G, Mozambique, Plasmodium falciparum, Postpartum Period, Pregnancy, Young Adult",

author = "Alfredo Mayor and Elisa Serra-Casas and Eduard Rovira-Vallbona and Alfons Jim{\'e}nez and Lloren{\c c} Quint{\'o} and Betuel Siga{\'u}que and Carlota Doba{\~n}o and Azucena Bardaj{\'i} and Alonso, {Pedro L} and Clara Men{\'e}ndez",

year = "2012",

doi = "10.1186/1475-2875-11-130",

language = "English",

volume = "11",

pages = "130",

journal = "Malaria Journal",

issn = "1475-2875",

publisher = "BioMed Central",

}

TY - JOUR

T1 - Immunoglobulins against the surface of Plasmodium falciparum-infected erythrocytes increase one month after delivery

AU - Mayor, Alfredo

AU - Serra-Casas, Elisa

AU - Rovira-Vallbona, Eduard

AU - Jiménez, Alfons

AU - Quintó, Llorenç

AU - Sigaúque, Betuel

AU - Dobaño, Carlota

AU - Bardají, Azucena

AU - Alonso, Pedro L

AU - Menéndez, Clara

PY - 2012

Y1 - 2012

N2 - BACKGROUND: The risk of Plasmodium falciparum malaria increases during pregnancy and at early postpartum. Immunological and physiological alterations associated with pregnancy that persist after delivery may contribute to the susceptibility to P. falciparum during early postpartum period.METHODS: To determine changes in antibody-mediated responses after pregnancy, levels of Immunoglobulin G (IgGs) specific for P. falciparum were compared in 200 pairs of plasmas collected from Mozambican women at delivery and during the first two months postpartum. IgGs against the surface of erythrocytes infected with a P. falciparum chondroitin sulphate A binding line (CS2) and a paediatric isolate (MOZ2) were measured by flow cytometry.RESULTS: IgG levels against CS2 and MOZ2 were higher at postpartum than at delivery (p = 0.033 and p = 0.045, respectively) in women without P. falciparum infection. The analysis stratified by parity and period after delivery showed that this increase was significant in multi-gravid women (p = 0.023 for CS2 and p = 0.054 for MOZ2) and during the second month after delivery (p = 0.018 for CS2 and p = 0.015 for MOZ2).CONCLUSIONS: These results support the view that early postpartum is a period of recovery from physiological or immunological changes associated with pregnancy.

AB - BACKGROUND: The risk of Plasmodium falciparum malaria increases during pregnancy and at early postpartum. Immunological and physiological alterations associated with pregnancy that persist after delivery may contribute to the susceptibility to P. falciparum during early postpartum period.METHODS: To determine changes in antibody-mediated responses after pregnancy, levels of Immunoglobulin G (IgGs) specific for P. falciparum were compared in 200 pairs of plasmas collected from Mozambican women at delivery and during the first two months postpartum. IgGs against the surface of erythrocytes infected with a P. falciparum chondroitin sulphate A binding line (CS2) and a paediatric isolate (MOZ2) were measured by flow cytometry.RESULTS: IgG levels against CS2 and MOZ2 were higher at postpartum than at delivery (p = 0.033 and p = 0.045, respectively) in women without P. falciparum infection. The analysis stratified by parity and period after delivery showed that this increase was significant in multi-gravid women (p = 0.023 for CS2 and p = 0.054 for MOZ2) and during the second month after delivery (p = 0.018 for CS2 and p = 0.015 for MOZ2).CONCLUSIONS: These results support the view that early postpartum is a period of recovery from physiological or immunological changes associated with pregnancy.

KW - Adult

KW - Antibodies, Protozoan

KW - Erythrocytes

KW - Female

KW - Flow Cytometry

KW - Humans

KW - Immunoglobulin G

KW - Mozambique

KW - Plasmodium falciparum

KW - Postpartum Period

KW - Pregnancy

KW - Young Adult

U2 - 10.1186/1475-2875-11-130

DO - 10.1186/1475-2875-11-130

M3 - A1: Web of Science-article

C2 - 22533971

SN - 1475-2875

VL - 11

SP - 130

JO - Malaria Journal

JF - Malaria Journal

ER -

Immunoglobulins against the surface of Plasmodium falciparum-infected erythrocytes increase one month after delivery

Abstract

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