Important considerations regarding the widespread use of doxycycline chemoprophylaxis against sexually transmitted infections

Fabian Yuh Shiong Kong, Chris Kenyon, Magnus Unemo

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Rates of sexually transmitted infections (STIs) continue to rise across the world and interventions are essential to reduce their incidence. Past and recent studies have indicated this may be achieved using doxycycline post-exposure prophylaxis (PEP) and this has sparked considerable interest in its use. However, many unanswered questions remain as to its long-term effects and particularly potentially negative impact on human microbiomes and antimicrobial resistance among STIs, other pathogens, and commensals. In this review, we discuss seven areas of concern pertaining to the widespread use of doxycycline PEP.

Original languageEnglish
JournalJournal of Antimicrobial Chemotherapy
Issue number7
Pages (from-to)1561-1568
Number of pages8
Publication statusPublished - 2023


  • Chemoprevention
  • Doxycycline/therapeutic use
  • HIV Infections/drug therapy
  • Humans
  • Incidence
  • Post-Exposure Prophylaxis
  • Sexually Transmitted Diseases/epidemiology

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