Inadequacy of the current WHO re-treatment regimen in a central Siberian prison: treatment failure and MDR-TB

ME Kimerling; H Kluge; N Vezhnina; T Iacovazzi; T Demeulenaere; F Portaels; F Matthys

Inadequacy of the current WHO re-treatment regimen in a central Siberian prison: treatment failure and MDR-TB

ME Kimerling, H Kluge, N Vezhnina, T Iacovazzi, T Demeulenaere, F Portaels, F Matthys

Mycobacteriology

Research output: Contribution to journal › A1: Web of Science-article › peer-review

Abstract

Multidrug-resistant tuberculosis (MDR-TB) threatens the progress of global control efforts. Prisons represent a high risk setting for development and transmission of MDR-TB. In a Siberian TB referral prison (Kemerovo region), the treatment failure rate is 35% (June 1996 –March 1997), despite implementation of a strict DOTS program and use of the World Health Organization Category 2 re-treatment regimen for all new cases. Among 164 patients (December 1997–March 1998), initial resistance to isoniazid and rifampin is 22.6%. Such a rate is a warning call to reconsider prison control strategies, and importantly, to address the treatment regimens necessary to combat an institutional epidemic of MDR-TB.

Original language	English
Journal	International Journal of Tuberculosis and Lung Disease
Volume	3
Pages (from-to)	451-453
ISSN	1027-3719
Publication status	Published - 1999

Keywords

B780-tropical-medicine
Bacterial diseases
Tuberculosis
Treatment
Regimens
Drug resistance
Siberia
Russia
Europe-East

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http://lib.itg.be/pdf/itg/1999/1999ijtl0451.pdf

Cite this

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title = "Inadequacy of the current WHO re-treatment regimen in a central Siberian prison: treatment failure and MDR-TB",

abstract = "Multidrug-resistant tuberculosis (MDR-TB) threatens the progress of global control efforts. Prisons represent a high risk setting for development and transmission of MDR-TB. In a Siberian TB referral prison (Kemerovo region), the treatment failure rate is 35% (June 1996 –March 1997), despite implementation of a strict DOTS program and use of the World Health Organization Category 2 re-treatment regimen for all new cases. Among 164 patients (December 1997–March 1998), initial resistance to isoniazid and rifampin is 22.6%. Such a rate is a warning call to reconsider prison control strategies, and importantly, to address the treatment regimens necessary to combat an institutional epidemic of MDR-TB.",

keywords = "B780-tropical-medicine, Bacterial diseases, Tuberculosis, Treatment, Regimens, Drug resistance, Siberia, Russia, Europe-East",

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TY - JOUR

T1 - Inadequacy of the current WHO re-treatment regimen in a central Siberian prison: treatment failure and MDR-TB

AU - Kimerling, ME

AU - Kluge, H

AU - Vezhnina, N

AU - Iacovazzi, T

AU - Demeulenaere, T

AU - Portaels, F

AU - Matthys, F

N1 - FTX: Abonnement

PY - 1999

Y1 - 1999

N2 - Multidrug-resistant tuberculosis (MDR-TB) threatens the progress of global control efforts. Prisons represent a high risk setting for development and transmission of MDR-TB. In a Siberian TB referral prison (Kemerovo region), the treatment failure rate is 35% (June 1996 –March 1997), despite implementation of a strict DOTS program and use of the World Health Organization Category 2 re-treatment regimen for all new cases. Among 164 patients (December 1997–March 1998), initial resistance to isoniazid and rifampin is 22.6%. Such a rate is a warning call to reconsider prison control strategies, and importantly, to address the treatment regimens necessary to combat an institutional epidemic of MDR-TB.

AB - Multidrug-resistant tuberculosis (MDR-TB) threatens the progress of global control efforts. Prisons represent a high risk setting for development and transmission of MDR-TB. In a Siberian TB referral prison (Kemerovo region), the treatment failure rate is 35% (June 1996 –March 1997), despite implementation of a strict DOTS program and use of the World Health Organization Category 2 re-treatment regimen for all new cases. Among 164 patients (December 1997–March 1998), initial resistance to isoniazid and rifampin is 22.6%. Such a rate is a warning call to reconsider prison control strategies, and importantly, to address the treatment regimens necessary to combat an institutional epidemic of MDR-TB.

KW - B780-tropical-medicine

KW - Bacterial diseases

KW - Tuberculosis

KW - Treatment

KW - Regimens

KW - Drug resistance

KW - Siberia

KW - Russia

KW - Europe-East

UR - https://www.webofscience.com/wos/woscc/full-record/WOS:000080215200016

M3 - A1: Web of Science-article

C2 - 10331736

SN - 1027-3719

VL - 3

SP - 451

EP - 453

JO - International Journal of Tuberculosis and Lung Disease

JF - International Journal of Tuberculosis and Lung Disease

ER -

Inadequacy of the current WHO re-treatment regimen in a central Siberian prison: treatment failure and MDR-TB

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Keywords

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