Incidence of human granulocytic anaplasmosis in returning travellers with fever

Daniel Camprubí-Ferrer, Aránzazu Portillo, Sonia Santibáñez, Alejandro Almuedo-Riera, Natalia Rodriguez-Valero, Carme Subirà, Miguel J Martinez, Jessica Navero-Castillejos, Marc Fernandez-Pardos, Blaise Genton, Ludovico Cobuccio, Steven Van Den Broucke, Emmanuel Bottieau, Jose Muñoz, José Antonio Oteo

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BACKGROUND: Although tick-borne pathogens have been reported as an important cause of imported fever, the incidence of Anaplasma phagocytophilum, the causative agent of human granulocytic anaplasmosis (HGA), in travellers is unknown.

METHODS: We conducted a prospective cohort study to investigate the aetiologies of fever in returning travellers (November 2017-July 2019). Polymerase chain reaction for msp2 gene amplification and indirect immunofluorescence assay for A. phagocitophilum were performed in all returning travellers with undifferentiated non-malarial fever.

RESULTS: Among 141 travellers included, 8 patients were diagnosed with probable or confirmed HGA. The overall incidence rate of HGA was 19.9 cases/1000 person-week of travel. The main destination of travel was Asia, accounting for 62.5% patients with HGA. Co-infections were found in 37.5% of patients with HGA.

CONCLUSIONS: Diagnosis of HGA and empirical treatment with doxycycline should be considered in travellers with fever.

Original languageEnglish
Article numbertaab056
JournalJournal of Travel Medicine
Issue number4
Number of pages6
Publication statusPublished - 2021


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