Incidence of human granulocytic anaplasmosis in returning travellers with fever

Daniel Camprubí-Ferrer; Aránzazu Portillo; Sonia Santibáñez; Alejandro Almuedo-Riera; Natalia Rodriguez-Valero; Carme Subirà; Miguel J Martinez; Jessica Navero-Castillejos; Marc Fernandez-Pardos; Blaise Genton; Ludovico Cobuccio; Steven Van Den Broucke; Emmanuel Bottieau; Jose Muñoz; José Antonio Oteo

doi:10.1093/jtm/taab056

Incidence of human granulocytic anaplasmosis in returning travellers with fever

Daniel Camprubí-Ferrer, Aránzazu Portillo, Sonia Santibáñez, Alejandro Almuedo-Riera, Natalia Rodriguez-Valero, Carme Subirà, Miguel J Martinez, Jessica Navero-Castillejos, Marc Fernandez-Pardos, Blaise Genton, Ludovico Cobuccio, Steven Van Den Broucke, Emmanuel Bottieau, Jose Muñoz, José Antonio Oteo

Tropical Medicine

Research output: Contribution to journal › A1: Web of Science-article › peer-review

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Abstract

BACKGROUND: Although tick-borne pathogens have been reported as an important cause of imported fever, the incidence of Anaplasma phagocytophilum, the causative agent of human granulocytic anaplasmosis (HGA), in travellers is unknown.

METHODS: We conducted a prospective cohort study to investigate the aetiologies of fever in returning travellers (November 2017-July 2019). Polymerase chain reaction for msp2 gene amplification and indirect immunofluorescence assay for A. phagocitophilum were performed in all returning travellers with undifferentiated non-malarial fever.

RESULTS: Among 141 travellers included, 8 patients were diagnosed with probable or confirmed HGA. The overall incidence rate of HGA was 19.9 cases/1000 person-week of travel. The main destination of travel was Asia, accounting for 62.5% patients with HGA. Co-infections were found in 37.5% of patients with HGA.

CONCLUSIONS: Diagnosis of HGA and empirical treatment with doxycycline should be considered in travellers with fever.

Original language	English
Article number	taab056
Journal	Journal of Travel Medicine
Volume	28
Issue number	4
Number of pages	6
ISSN	1195-1982
DOIs	https://doi.org/10.1093/jtm/taab056
Publication status	Published - 2021

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10.1093/jtm/taab056Licence: Other

2021jtmetaab056Final published version, 1.04 MBLicence: Other

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Camprubí-Ferrer, D., Portillo, A., Santibáñez, S., Almuedo-Riera, A., Rodriguez-Valero, N., Subirà, C., Martinez, M. J., Navero-Castillejos, J., Fernandez-Pardos, M., Genton, B., Cobuccio, L., Van Den Broucke, S., Bottieau, E., Muñoz, J., & Oteo, J. A. (2021). Incidence of human granulocytic anaplasmosis in returning travellers with fever. Journal of Travel Medicine, 28(4), Article taab056. https://doi.org/10.1093/jtm/taab056

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title = "Incidence of human granulocytic anaplasmosis in returning travellers with fever",

abstract = "BACKGROUND: Although tick-borne pathogens have been reported as an important cause of imported fever, the incidence of Anaplasma phagocytophilum, the causative agent of human granulocytic anaplasmosis (HGA), in travellers is unknown.METHODS: We conducted a prospective cohort study to investigate the aetiologies of fever in returning travellers (November 2017-July 2019). Polymerase chain reaction for msp2 gene amplification and indirect immunofluorescence assay for A. phagocitophilum were performed in all returning travellers with undifferentiated non-malarial fever.RESULTS: Among 141 travellers included, 8 patients were diagnosed with probable or confirmed HGA. The overall incidence rate of HGA was 19.9 cases/1000 person-week of travel. The main destination of travel was Asia, accounting for 62.5% patients with HGA. Co-infections were found in 37.5% of patients with HGA.CONCLUSIONS: Diagnosis of HGA and empirical treatment with doxycycline should be considered in travellers with fever.",

author = "Daniel Camprub{\'i}-Ferrer and Ar{\'a}nzazu Portillo and Sonia Santib{\'a}{\~n}ez and Alejandro Almuedo-Riera and Natalia Rodriguez-Valero and Carme Subir{\`a} and Martinez, {Miguel J} and Jessica Navero-Castillejos and Marc Fernandez-Pardos and Blaise Genton and Ludovico Cobuccio and {Van Den Broucke}, Steven and Emmanuel Bottieau and Jose Mu{\~n}oz and Oteo, {Jos{\'e} Antonio}",

year = "2021",

doi = "10.1093/jtm/taab056",

language = "English",

volume = "28",

journal = "Journal of Travel Medicine",

issn = "1195-1982",

publisher = "Oxford University Press",

number = "4",

}

Camprubí-Ferrer, D, Portillo, A, Santibáñez, S, Almuedo-Riera, A, Rodriguez-Valero, N, Subirà, C, Martinez, MJ, Navero-Castillejos, J, Fernandez-Pardos, M, Genton, B, Cobuccio, L, Van Den Broucke, S , Bottieau, E, Muñoz, J & Oteo, JA 2021, 'Incidence of human granulocytic anaplasmosis in returning travellers with fever', Journal of Travel Medicine, vol. 28, no. 4, taab056. https://doi.org/10.1093/jtm/taab056

TY - JOUR

T1 - Incidence of human granulocytic anaplasmosis in returning travellers with fever

AU - Camprubí-Ferrer, Daniel

AU - Portillo, Aránzazu

AU - Santibáñez, Sonia

AU - Almuedo-Riera, Alejandro

AU - Rodriguez-Valero, Natalia

AU - Subirà, Carme

AU - Martinez, Miguel J

AU - Navero-Castillejos, Jessica

AU - Fernandez-Pardos, Marc

AU - Genton, Blaise

AU - Cobuccio, Ludovico

AU - Van Den Broucke, Steven

AU - Bottieau, Emmanuel

AU - Muñoz, Jose

AU - Oteo, José Antonio

PY - 2021

Y1 - 2021

N2 - BACKGROUND: Although tick-borne pathogens have been reported as an important cause of imported fever, the incidence of Anaplasma phagocytophilum, the causative agent of human granulocytic anaplasmosis (HGA), in travellers is unknown.METHODS: We conducted a prospective cohort study to investigate the aetiologies of fever in returning travellers (November 2017-July 2019). Polymerase chain reaction for msp2 gene amplification and indirect immunofluorescence assay for A. phagocitophilum were performed in all returning travellers with undifferentiated non-malarial fever.RESULTS: Among 141 travellers included, 8 patients were diagnosed with probable or confirmed HGA. The overall incidence rate of HGA was 19.9 cases/1000 person-week of travel. The main destination of travel was Asia, accounting for 62.5% patients with HGA. Co-infections were found in 37.5% of patients with HGA.CONCLUSIONS: Diagnosis of HGA and empirical treatment with doxycycline should be considered in travellers with fever.

AB - BACKGROUND: Although tick-borne pathogens have been reported as an important cause of imported fever, the incidence of Anaplasma phagocytophilum, the causative agent of human granulocytic anaplasmosis (HGA), in travellers is unknown.METHODS: We conducted a prospective cohort study to investigate the aetiologies of fever in returning travellers (November 2017-July 2019). Polymerase chain reaction for msp2 gene amplification and indirect immunofluorescence assay for A. phagocitophilum were performed in all returning travellers with undifferentiated non-malarial fever.RESULTS: Among 141 travellers included, 8 patients were diagnosed with probable or confirmed HGA. The overall incidence rate of HGA was 19.9 cases/1000 person-week of travel. The main destination of travel was Asia, accounting for 62.5% patients with HGA. Co-infections were found in 37.5% of patients with HGA.CONCLUSIONS: Diagnosis of HGA and empirical treatment with doxycycline should be considered in travellers with fever.

U2 - 10.1093/jtm/taab056

DO - 10.1093/jtm/taab056

M3 - A1: Web of Science-article

C2 - 33839778

SN - 1195-1982

VL - 28

JO - Journal of Travel Medicine

JF - Journal of Travel Medicine

IS - 4

M1 - taab056

ER -

Incidence of human granulocytic anaplasmosis in returning travellers with fever

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