TY - JOUR
T1 - Incidence of human granulocytic anaplasmosis in returning travellers with fever
AU - Camprubí-Ferrer, Daniel
AU - Portillo, Aránzazu
AU - Santibáñez, Sonia
AU - Almuedo-Riera, Alejandro
AU - Rodriguez-Valero, Natalia
AU - Subirà, Carme
AU - Martinez, Miguel J
AU - Navero-Castillejos, Jessica
AU - Fernandez-Pardos, Marc
AU - Genton, Blaise
AU - Cobuccio, Ludovico
AU - Van Den Broucke, Steven
AU - Bottieau, Emmanuel
AU - Muñoz, Jose
AU - Oteo, José Antonio
N1 - FTX; OGOA; © International Society of Travel Medicine 2021. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: [email protected].
PY - 2021
Y1 - 2021
N2 - BACKGROUND: Although tick-borne pathogens have been reported as an important cause of imported fever, the incidence of Anaplasma phagocytophilum, the causative agent of human granulocytic anaplasmosis (HGA), in travellers is unknown.METHODS: We conducted a prospective cohort study to investigate the aetiologies of fever in returning travellers (November 2017-July 2019). Polymerase chain reaction for msp2 gene amplification and indirect immunofluorescence assay for A. phagocitophilum were performed in all returning travellers with undifferentiated non-malarial fever.RESULTS: Among 141 travellers included, 8 patients were diagnosed with probable or confirmed HGA. The overall incidence rate of HGA was 19.9 cases/1000 person-week of travel. The main destination of travel was Asia, accounting for 62.5% patients with HGA. Co-infections were found in 37.5% of patients with HGA.CONCLUSIONS: Diagnosis of HGA and empirical treatment with doxycycline should be considered in travellers with fever.
AB - BACKGROUND: Although tick-borne pathogens have been reported as an important cause of imported fever, the incidence of Anaplasma phagocytophilum, the causative agent of human granulocytic anaplasmosis (HGA), in travellers is unknown.METHODS: We conducted a prospective cohort study to investigate the aetiologies of fever in returning travellers (November 2017-July 2019). Polymerase chain reaction for msp2 gene amplification and indirect immunofluorescence assay for A. phagocitophilum were performed in all returning travellers with undifferentiated non-malarial fever.RESULTS: Among 141 travellers included, 8 patients were diagnosed with probable or confirmed HGA. The overall incidence rate of HGA was 19.9 cases/1000 person-week of travel. The main destination of travel was Asia, accounting for 62.5% patients with HGA. Co-infections were found in 37.5% of patients with HGA.CONCLUSIONS: Diagnosis of HGA and empirical treatment with doxycycline should be considered in travellers with fever.
U2 - 10.1093/jtm/taab056
DO - 10.1093/jtm/taab056
M3 - A1: Web of Science-article
C2 - 33839778
SN - 1195-1982
VL - 28
JO - Journal of Travel Medicine
JF - Journal of Travel Medicine
IS - 4
M1 - taab056
ER -