Incidence of influenza-associated mortality and hospitalizations in Argentina during 2002-2009

Eduardo Azziz-Baumgartner; Ana María Cabrera; Po-Yung Cheng; Enio Garcia; Gabriela Kusznierz; Rogelio Calli; Clarisa Baez; María Pía Buyayisqui; Eleonora Poyard; Emanuel Pérez; Ricardo Basurto-Davila; Rakhee Palekar; Otavio Oliva; Airlane Pereira Alencar; Regilo de Souza; Thais dos Santos; David K Shay; Marc-Alain Widdowson; Joseph Breese; Horacio Echenique

doi:10.1111/irv.12022

Incidence of influenza-associated mortality and hospitalizations in Argentina during 2002-2009

Eduardo Azziz-Baumgartner, Ana María Cabrera, Po-Yung Cheng, Enio Garcia, Gabriela Kusznierz, Rogelio Calli, Clarisa Baez, María Pía Buyayisqui, Eleonora Poyard, Emanuel Pérez, Ricardo Basurto-Davila, Rakhee Palekar, Otavio Oliva, Airlane Pereira Alencar, Regilo de Souza, Thais dos Santos, David K Shay, Marc-Alain Widdowson, Joseph Breese, Horacio Echenique

Institute of Tropical Medicine

Research output: Contribution to journal › A1: Web of Science-article › peer-review

Abstract

BACKGROUND: We estimated rates of influenza-associated deaths and hospitalizations in Argentina, a country that recommends annual influenza vaccination for persons at high risk of complications from influenza illness.

METHODS: We identified hospitalized persons and deaths in persons diagnosed with pneumonia and influenza (P&I, ICD-10 codes J10-J18) and respiratory and circulatory illness (R&C, codes I00-I99 and J00-J99). We defined the influenza season as the months when the proportion of samples that tested positive for influenza exceeded the annual median. We used hospitalizations and deaths during the influenza off-season to estimate, using linear regression, the number of excess deaths that occurred during the influenza season. To explore whether excess mortality varied by sex and whether people were age <65 or ≥ 65 years, we used Poisson regression of the influenza-associated rates.

RESULTS: During 2002-2009, 2411 P&I and 8527 R&C mean excess deaths occurred annually from May to October. If all of these excess deaths were associated with influenza, the influenza-associated mortality rate was 6/100,000 person-years (95% CI 4-8/100,000 person-years for P&I and 21/100,000 person-years (95% CI 12-31/100,000 person-years) for R&C. During 2005-2008, we identified an average of 7868 P&I excess hospitalizations and 22,994 R&C hospitalizations per year, resulting in an influenza-associated hospitalization rate of 2/10,000 person-years (95% CI 1-3/10,000 person-years) for P&I and 6/10,000 person-years (95% CI 3-8/10,000 person-years) for R&C.

CONCLUSION: Our findings suggest that annual rates of influenza-associated hospitalizations and death in Argentina were substantial and similar to neighboring Brazil.

Original language	English
Journal	Influenza and Other Respiratory Viruses
Volume	7
Issue number	5
Pages (from-to)	710-717
Number of pages	8
ISSN	1750-2640
DOIs	https://doi.org/10.1111/irv.12022
Publication status	Published - 2013

Keywords

Aged
Aged, 80 and over
Argentina/epidemiology
Female
Hospitalization/statistics & numerical data
Humans
Incidence
Influenza, Human/epidemiology
Male

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Azziz-Baumgartner, E., Cabrera, A. M., Cheng, P.-Y., Garcia, E., Kusznierz, G., Calli, R., Baez, C., Buyayisqui, M. P., Poyard, E., Pérez, E., Basurto-Davila, R., Palekar, R., Oliva, O., Alencar, A. P., de Souza, R., dos Santos, T., Shay, D. K., Widdowson, M.-A., Breese, J., & Echenique, H. (2013). Incidence of influenza-associated mortality and hospitalizations in Argentina during 2002-2009. Influenza and Other Respiratory Viruses, 7(5), 710-717. https://doi.org/10.1111/irv.12022

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title = "Incidence of influenza-associated mortality and hospitalizations in Argentina during 2002-2009",

abstract = "BACKGROUND: We estimated rates of influenza-associated deaths and hospitalizations in Argentina, a country that recommends annual influenza vaccination for persons at high risk of complications from influenza illness.METHODS: We identified hospitalized persons and deaths in persons diagnosed with pneumonia and influenza (P&I, ICD-10 codes J10-J18) and respiratory and circulatory illness (R&C, codes I00-I99 and J00-J99). We defined the influenza season as the months when the proportion of samples that tested positive for influenza exceeded the annual median. We used hospitalizations and deaths during the influenza off-season to estimate, using linear regression, the number of excess deaths that occurred during the influenza season. To explore whether excess mortality varied by sex and whether people were age <65 or ≥ 65 years, we used Poisson regression of the influenza-associated rates.RESULTS: During 2002-2009, 2411 P&I and 8527 R&C mean excess deaths occurred annually from May to October. If all of these excess deaths were associated with influenza, the influenza-associated mortality rate was 6/100,000 person-years (95% CI 4-8/100,000 person-years for P&I and 21/100,000 person-years (95% CI 12-31/100,000 person-years) for R&C. During 2005-2008, we identified an average of 7868 P&I excess hospitalizations and 22,994 R&C hospitalizations per year, resulting in an influenza-associated hospitalization rate of 2/10,000 person-years (95% CI 1-3/10,000 person-years) for P&I and 6/10,000 person-years (95% CI 3-8/10,000 person-years) for R&C.CONCLUSION: Our findings suggest that annual rates of influenza-associated hospitalizations and death in Argentina were substantial and similar to neighboring Brazil.",

keywords = "Aged, Aged, 80 and over, Argentina/epidemiology, Female, Hospitalization/statistics & numerical data, Humans, Incidence, Influenza, Human/epidemiology, Male",

author = "Eduardo Azziz-Baumgartner and Cabrera, {Ana Mar{\'i}a} and Po-Yung Cheng and Enio Garcia and Gabriela Kusznierz and Rogelio Calli and Clarisa Baez and Buyayisqui, {Mar{\'i}a P{\'i}a} and Eleonora Poyard and Emanuel P{\'e}rez and Ricardo Basurto-Davila and Rakhee Palekar and Otavio Oliva and Alencar, {Airlane Pereira} and {de Souza}, Regilo and {dos Santos}, Thais and Shay, {David K} and Marc-Alain Widdowson and Joseph Breese and Horacio Echenique",

note = "Published 2012. This article is a US Government work and is in the public domain in the USA.",

year = "2013",

doi = "10.1111/irv.12022",

language = "English",

volume = "7",

pages = "710--717",

journal = "Influenza and Other Respiratory Viruses",

issn = "1750-2640",

publisher = "John Wiley & Sons",

number = "5",

}

Azziz-Baumgartner, E, Cabrera, AM, Cheng, P-Y, Garcia, E, Kusznierz, G, Calli, R, Baez, C, Buyayisqui, MP, Poyard, E, Pérez, E, Basurto-Davila, R, Palekar, R, Oliva, O, Alencar, AP, de Souza, R, dos Santos, T, Shay, DK, Widdowson, M-A, Breese, J & Echenique, H 2013, 'Incidence of influenza-associated mortality and hospitalizations in Argentina during 2002-2009', Influenza and Other Respiratory Viruses, vol. 7, no. 5, pp. 710-717. https://doi.org/10.1111/irv.12022

TY - JOUR

T1 - Incidence of influenza-associated mortality and hospitalizations in Argentina during 2002-2009

AU - Azziz-Baumgartner, Eduardo

AU - Cabrera, Ana María

AU - Cheng, Po-Yung

AU - Garcia, Enio

AU - Kusznierz, Gabriela

AU - Calli, Rogelio

AU - Baez, Clarisa

AU - Buyayisqui, María Pía

AU - Poyard, Eleonora

AU - Pérez, Emanuel

AU - Basurto-Davila, Ricardo

AU - Palekar, Rakhee

AU - Oliva, Otavio

AU - Alencar, Airlane Pereira

AU - de Souza, Regilo

AU - dos Santos, Thais

AU - Shay, David K

AU - Widdowson, Marc-Alain

AU - Breese, Joseph

AU - Echenique, Horacio

N1 - Published 2012. This article is a US Government work and is in the public domain in the USA.

PY - 2013

Y1 - 2013

N2 - BACKGROUND: We estimated rates of influenza-associated deaths and hospitalizations in Argentina, a country that recommends annual influenza vaccination for persons at high risk of complications from influenza illness.METHODS: We identified hospitalized persons and deaths in persons diagnosed with pneumonia and influenza (P&I, ICD-10 codes J10-J18) and respiratory and circulatory illness (R&C, codes I00-I99 and J00-J99). We defined the influenza season as the months when the proportion of samples that tested positive for influenza exceeded the annual median. We used hospitalizations and deaths during the influenza off-season to estimate, using linear regression, the number of excess deaths that occurred during the influenza season. To explore whether excess mortality varied by sex and whether people were age <65 or ≥ 65 years, we used Poisson regression of the influenza-associated rates.RESULTS: During 2002-2009, 2411 P&I and 8527 R&C mean excess deaths occurred annually from May to October. If all of these excess deaths were associated with influenza, the influenza-associated mortality rate was 6/100,000 person-years (95% CI 4-8/100,000 person-years for P&I and 21/100,000 person-years (95% CI 12-31/100,000 person-years) for R&C. During 2005-2008, we identified an average of 7868 P&I excess hospitalizations and 22,994 R&C hospitalizations per year, resulting in an influenza-associated hospitalization rate of 2/10,000 person-years (95% CI 1-3/10,000 person-years) for P&I and 6/10,000 person-years (95% CI 3-8/10,000 person-years) for R&C.CONCLUSION: Our findings suggest that annual rates of influenza-associated hospitalizations and death in Argentina were substantial and similar to neighboring Brazil.

AB - BACKGROUND: We estimated rates of influenza-associated deaths and hospitalizations in Argentina, a country that recommends annual influenza vaccination for persons at high risk of complications from influenza illness.METHODS: We identified hospitalized persons and deaths in persons diagnosed with pneumonia and influenza (P&I, ICD-10 codes J10-J18) and respiratory and circulatory illness (R&C, codes I00-I99 and J00-J99). We defined the influenza season as the months when the proportion of samples that tested positive for influenza exceeded the annual median. We used hospitalizations and deaths during the influenza off-season to estimate, using linear regression, the number of excess deaths that occurred during the influenza season. To explore whether excess mortality varied by sex and whether people were age <65 or ≥ 65 years, we used Poisson regression of the influenza-associated rates.RESULTS: During 2002-2009, 2411 P&I and 8527 R&C mean excess deaths occurred annually from May to October. If all of these excess deaths were associated with influenza, the influenza-associated mortality rate was 6/100,000 person-years (95% CI 4-8/100,000 person-years for P&I and 21/100,000 person-years (95% CI 12-31/100,000 person-years) for R&C. During 2005-2008, we identified an average of 7868 P&I excess hospitalizations and 22,994 R&C hospitalizations per year, resulting in an influenza-associated hospitalization rate of 2/10,000 person-years (95% CI 1-3/10,000 person-years) for P&I and 6/10,000 person-years (95% CI 3-8/10,000 person-years) for R&C.CONCLUSION: Our findings suggest that annual rates of influenza-associated hospitalizations and death in Argentina were substantial and similar to neighboring Brazil.

KW - Aged

KW - Aged, 80 and over

KW - Argentina/epidemiology

KW - Female

KW - Hospitalization/statistics & numerical data

KW - Humans

KW - Incidence

KW - Influenza, Human/epidemiology

KW - Male

U2 - 10.1111/irv.12022

DO - 10.1111/irv.12022

M3 - A1: Web of Science-article

C2 - 23210456

SN - 1750-2640

VL - 7

SP - 710

EP - 717

JO - Influenza and Other Respiratory Viruses

JF - Influenza and Other Respiratory Viruses

IS - 5

ER -

Incidence of influenza-associated mortality and hospitalizations in Argentina during 2002-2009

Abstract

Keywords

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