Incidence of symptomatic and asymptomatic Leishmania donovani infections in high-endemic foci in India and Nepal: a prospective study

B Ostyn, K Gidwani, B Khanal, A Picado, F Chappuis, SP Singh, S Rijal, S Sundar, M Boelaert

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    Abstract

    Incidence of Leishmania donovani infection and Visceral Leishmaniasis (VL) was assessed in a prospective study in Indian and Nepalese high-endemic villages. DAT-seroconversion was used as marker of incident infection in 3 yearly surveys. The study population was followed up to month 30 to identify incident clinical cases. In a cohort of 9034 DAT-negative individuals with neither active signs nor history of VL at baseline, 42 VL cases and 375 asymptomatic seroconversions were recorded in the first year, giving an infectionratiodisease ratio of 8.9 to 1. In the 18 months' follow-up, 7 extra cases of VL were observed in the seroconverters group (N = 375), against 14 VL cases among the individuals who had not seroconverted in the first year (N = 8570) (RR = 11.5(4.5<RR<28.3)). Incident asymptomatic L. donovani infection in VL high-endemic foci in India and Nepal is nine times more frequent than incident VL disease. About 1 in 50 of these new but latent infections led to VL within the next 18 months.
    Original languageEnglish
    JournalPLoS Neglected Tropical Diseases
    Volume5
    Issue number10
    Pages (from-to)e1284
    ISSN1935-2727
    DOIs
    Publication statusPublished - 2011

    Keywords

    • B780-tropical-medicine
    • Protozoal diseases
    • Leishmaniasis
    • Visceral
    • Kala azar
    • Asymptomatic
    • Leishmania donovani
    • Vectors
    • Sandflies
    • Phlebotomus argentipes
    • Incidence
    • DAT
    • Seroconversion
    • Markers
    • Follow-up
    • Endemic area
    • India
    • Nepal
    • Asia-South

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