Infection palustre et état nutritionnel: résultats d'une cohorte d'enfants âgées de 6 - 59 mois au Kivu en République démocratique du Congo

P.N. Mitangala; Umberto D'Alessandro; P. Donnen; P. Hennart; D. Porignon; G. Bisimwa Balaluka; D. Zozo Nyarukweba; N. Cobohwa Mbiribindi; M. Dramaix Wilmet

doi:10.1016/j.respe.2012.06.404

Infection palustre et état nutritionnel: résultats d'une cohorte d'enfants âgées de 6 - 59 mois au Kivu en République démocratique du Congo

Translated title of the contribution: Malaria infection and nutritional status: Results from a cohort survey of children from 6–59 months old in the Kivu province, Democratic Republic of the Congo

P.N. Mitangala
, Umberto D'Alessandro
, P. Donnen
, P. Hennart
, D. Porignon
, G. Bisimwa Balaluka
, D. Zozo Nyarukweba
, N. Cobohwa Mbiribindi
, M. Dramaix Wilmet

Research output: Contribution to journal › A1: Peer-reviewed journal articles › peer-review

Abstract

Background
Despite a reduction in the magnitude of endemic malaria reported in recent years, malaria and protein-energy malnutrition (PEM) still remain major causes of morbidity and mortality in sub-Saharan Africa among children under five. The relationship between malaria and malnutrition remains a topic of controversy. We aimed to investigate malaria infection according to nutritional status in a community-based survey.
Methods
A cohort of 790 children aged 6 to 59 months and residing in eastern Democratic Republic of the Congo was followed-up from April 2009 to March 2010 with monthly visits. Data on nutritional status, morbidity between visits, use of insecticide-treated nets and malaria parasitemia were collected at each visit. The Z scores height for age, weight for age and weight for height were computed using the reference population defined by the WHO in 2006. Thresholds for Z scores were defined at −3 and −2. A binary logistic model of the generalized estimating equation (GEE) was used to quantify the association between PEM indicators and malaria parasitemia. Odds ratio (OR) and their 95% confidence interval (95% CI) were computed.
Results
After adjustment for season, children with severe stunting (height for age Z score < −3) were at lower risk of malaria parasitemia greater or equal to 5000 trophozoits/μL of blood as compared to those in with a better nutritional status (height for age Z score ≥ −2) (OR = 0.48, 95% CI: 0.25–0.91).
Conclusion
Severely stunted children are at a lower risk of high-level malaria parasitemia.

Translated title of the contribution	Malaria infection and nutritional status: Results from a cohort survey of children from 6–59 months old in the Kivu province, Democratic Republic of the Congo
Original language	French
Journal	Revue d'Epidémiologie et de Santé Publique
Volume	61
Issue number	2
Pages (from-to)	111-120
Number of pages	10
ISSN	0398-7620
DOIs	https://doi.org/10.1016/j.respe.2012.06.404
Publication status	Published - 2013

Keywords

Protozoal diseases
Malaria
Plasmodium falciparum
Vectors
Mosquitoes
Anopheles
Health impact
Nutrition status
Malnutrition
Stunting
Protein energy malnutrition
Children
Morbidity
Appropriate use
Impregnated bednets
Insecticides
Parasitemia
Risk
Congo-Kinshasa
Africa-Central

Access to Document

10.1016/j.respe.2012.06.404

http://lib.itg.be/pdf/itg/2013/2013resp0111.pdf

Cite this

Mitangala, P. N., D'Alessandro, U., Donnen, P., Hennart, P., Porignon, D., Bisimwa Balaluka, G., Zozo Nyarukweba, D., Cobohwa Mbiribindi, N., & Dramaix Wilmet, M. (2013). Infection palustre et état nutritionnel: résultats d'une cohorte d'enfants âgées de 6 - 59 mois au Kivu en République démocratique du Congo. Revue d'Epidémiologie et de Santé Publique, 61(2), 111-120. https://doi.org/10.1016/j.respe.2012.06.404

@article{9c5430e4acde44cc97bf5a916f614e15,

title = "Infection palustre et {\'e}tat nutritionnel: r{\'e}sultats d'une cohorte d'enfants {\^a}g{\'e}es de 6 - 59 mois au Kivu en R{\'e}publique d{\'e}mocratique du Congo",

abstract = "Background Despite a reduction in the magnitude of endemic malaria reported in recent years, malaria and protein-energy malnutrition (PEM) still remain major causes of morbidity and mortality in sub-Saharan Africa among children under five. The relationship between malaria and malnutrition remains a topic of controversy. We aimed to investigate malaria infection according to nutritional status in a community-based survey. Methods A cohort of 790 children aged 6 to 59 months and residing in eastern Democratic Republic of the Congo was followed-up from April 2009 to March 2010 with monthly visits. Data on nutritional status, morbidity between visits, use of insecticide-treated nets and malaria parasitemia were collected at each visit. The Z scores height for age, weight for age and weight for height were computed using the reference population defined by the WHO in 2006. Thresholds for Z scores were defined at −3 and −2. A binary logistic model of the generalized estimating equation (GEE) was used to quantify the association between PEM indicators and malaria parasitemia. Odds ratio (OR) and their 95\% confidence interval (95\% CI) were computed. Results After adjustment for season, children with severe stunting (height for age Z score < −3) were at lower risk of malaria parasitemia greater or equal to 5000 trophozoits/μL of blood as compared to those in with a better nutritional status (height for age Z score ≥ −2) (OR = 0.48, 95\% CI: 0.25–0.91). Conclusion Severely stunted children are at a lower risk of high-level malaria parasitemia.",

keywords = "Protozoal diseases, Malaria, Plasmodium falciparum, Vectors, Mosquitoes, Anopheles, Health impact, Nutrition status, Malnutrition, Stunting, Protein energy malnutrition, Children, Morbidity, Appropriate use, Impregnated bednets, Insecticides, Parasitemia, Risk, Congo-Kinshasa, Africa-Central",

author = "P.N. Mitangala and Umberto D'Alessandro and P. Donnen and P. Hennart and D. Porignon and \{Bisimwa Balaluka\}, G. and \{Zozo Nyarukweba\}, D. and \{Cobohwa Mbiribindi\}, N. and \{Dramaix Wilmet\}, M.",

note = "M1 - Rev �pid‚miol Sant‚ Publique",

year = "2013",

doi = "10.1016/j.respe.2012.06.404",

language = "French",

volume = "61",

pages = "111--120",

journal = "Revue d'Epid{\'e}miologie et de Sant{\'e} Publique",

issn = "0398-7620",

publisher = "Elsevier Masson",

number = "2",

}

Mitangala, PN, D'Alessandro, U, Donnen, P, Hennart, P, Porignon, D, Bisimwa Balaluka, G, Zozo Nyarukweba, D, Cobohwa Mbiribindi, N & Dramaix Wilmet, M 2013, 'Infection palustre et état nutritionnel: résultats d'une cohorte d'enfants âgées de 6 - 59 mois au Kivu en République démocratique du Congo', Revue d'Epidémiologie et de Santé Publique, vol. 61, no. 2, pp. 111-120. https://doi.org/10.1016/j.respe.2012.06.404

Infection palustre et état nutritionnel: résultats d'une cohorte d'enfants âgées de 6 - 59 mois au Kivu en République démocratique du Congo. / Mitangala, P.N.; D'Alessandro, Umberto; Donnen, P. et al.
In: Revue d'Epidémiologie et de Santé Publique, Vol. 61, No. 2, 2013, p. 111-120.

Research output: Contribution to journal › A1: Peer-reviewed journal articles › peer-review

TY - JOUR

T1 - Infection palustre et état nutritionnel: résultats d'une cohorte d'enfants âgées de 6 - 59 mois au Kivu en République démocratique du Congo

AU - Mitangala, P.N.

AU - D'Alessandro, Umberto

AU - Donnen, P.

AU - Hennart, P.

AU - Porignon, D.

AU - Bisimwa Balaluka, G.

AU - Zozo Nyarukweba, D.

AU - Cobohwa Mbiribindi, N.

AU - Dramaix Wilmet, M.

N1 - M1 - Rev �pid‚miol Sant‚ Publique

PY - 2013

Y1 - 2013

N2 - Background Despite a reduction in the magnitude of endemic malaria reported in recent years, malaria and protein-energy malnutrition (PEM) still remain major causes of morbidity and mortality in sub-Saharan Africa among children under five. The relationship between malaria and malnutrition remains a topic of controversy. We aimed to investigate malaria infection according to nutritional status in a community-based survey. Methods A cohort of 790 children aged 6 to 59 months and residing in eastern Democratic Republic of the Congo was followed-up from April 2009 to March 2010 with monthly visits. Data on nutritional status, morbidity between visits, use of insecticide-treated nets and malaria parasitemia were collected at each visit. The Z scores height for age, weight for age and weight for height were computed using the reference population defined by the WHO in 2006. Thresholds for Z scores were defined at −3 and −2. A binary logistic model of the generalized estimating equation (GEE) was used to quantify the association between PEM indicators and malaria parasitemia. Odds ratio (OR) and their 95% confidence interval (95% CI) were computed. Results After adjustment for season, children with severe stunting (height for age Z score < −3) were at lower risk of malaria parasitemia greater or equal to 5000 trophozoits/μL of blood as compared to those in with a better nutritional status (height for age Z score ≥ −2) (OR = 0.48, 95% CI: 0.25–0.91). Conclusion Severely stunted children are at a lower risk of high-level malaria parasitemia.

AB - Background Despite a reduction in the magnitude of endemic malaria reported in recent years, malaria and protein-energy malnutrition (PEM) still remain major causes of morbidity and mortality in sub-Saharan Africa among children under five. The relationship between malaria and malnutrition remains a topic of controversy. We aimed to investigate malaria infection according to nutritional status in a community-based survey. Methods A cohort of 790 children aged 6 to 59 months and residing in eastern Democratic Republic of the Congo was followed-up from April 2009 to March 2010 with monthly visits. Data on nutritional status, morbidity between visits, use of insecticide-treated nets and malaria parasitemia were collected at each visit. The Z scores height for age, weight for age and weight for height were computed using the reference population defined by the WHO in 2006. Thresholds for Z scores were defined at −3 and −2. A binary logistic model of the generalized estimating equation (GEE) was used to quantify the association between PEM indicators and malaria parasitemia. Odds ratio (OR) and their 95% confidence interval (95% CI) were computed. Results After adjustment for season, children with severe stunting (height for age Z score < −3) were at lower risk of malaria parasitemia greater or equal to 5000 trophozoits/μL of blood as compared to those in with a better nutritional status (height for age Z score ≥ −2) (OR = 0.48, 95% CI: 0.25–0.91). Conclusion Severely stunted children are at a lower risk of high-level malaria parasitemia.

KW - Protozoal diseases

KW - Malaria

KW - Plasmodium falciparum

KW - Vectors

KW - Mosquitoes

KW - Anopheles

KW - Health impact

KW - Nutrition status

KW - Malnutrition

KW - Stunting

KW - Protein energy malnutrition

KW - Children

KW - Morbidity

KW - Appropriate use

KW - Impregnated bednets

KW - Insecticides

KW - Parasitemia

KW - Risk

KW - Congo-Kinshasa

KW - Africa-Central

UR - https://www.webofscience.com/wos/woscc/full-record/WOS:000318009200005

U2 - 10.1016/j.respe.2012.06.404

DO - 10.1016/j.respe.2012.06.404

M3 - A1: Peer-reviewed journal articles

C2 - 23489948

SN - 0398-7620

VL - 61

SP - 111

EP - 120

JO - Revue d'Epidémiologie et de Santé Publique

JF - Revue d'Epidémiologie et de Santé Publique

IS - 2

ER -

Infection palustre et état nutritionnel: résultats d'une cohorte d'enfants âgées de 6 - 59 mois au Kivu en République démocratique du Congo

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this