Infection with versus exposure to Taenia solium: what do serological test results tell us?

N Praet, R Rodriguez-Hidalgo, N Speybroeck, S Ahounou, W Benitez-Ortiz, D Berkvens, A Van Hul, M Barrionuevo-Samaniego, C Saegerman, P Dorny

    Research output: Contribution to journalA1: Web of Science-article

    Abstract

    Taenia solium cysticercosis is an endemic zoonosis in many developing countries. Serological tests are the most appropriate diagnostic tools to understand the transmission dynamics of the parasite, but the performances of these methods in such a setting are not known. A south Ecuadorian human population living in an endemic area was tested using three common serological tests. Because none of them is a gold standard, a Bayesian Latent Class analysis was used to estimate the test characteristics. Two definitions of a case were considered to differentiate between prevalence of current infection and prior exposure to the parasite. Differences between the performances of the same test in function of the definition of a case were observed. This study shows that test results and prior information should be interpreted carefully in a Bayesian analysis framework, particularly when the latter is based on clinical studies
    Original languageEnglish
    JournalAmerican Journal of Tropical Medicine and Hygiene
    Volume83
    Issue number2
    Pages (from-to)413-415
    Number of pages3
    ISSN0002-9637
    DOIs
    Publication statusPublished - 2010

    Keywords

    • B780-tropical-medicine
    • Helminthic diseases
    • Zoonoses
    • Cysticercosis
    • Taenia solium
    • Diagnostics
    • Rapid diagnostic tests
    • Serological
    • Test kits
    • Performance
    • Comparison
    • Infection
    • Latent class analysis
    • Ag-ELISA
    • EITB
    • Ab-ELISA
    • Sensitivity
    • Specificity
    • Ecuador
    • America-Latin

    Fingerprint Dive into the research topics of 'Infection with versus exposure to <em>Taenia solium</em>: what do serological test results tell us?'. Together they form a unique fingerprint.

    Cite this