Influenza-associated mortality in 2009 in four sentinel sites in Bangladesh

Nusrat Homaira; Stephen P Luby; A S M Alamgir; Kariul Islam; Repon Paul; Jaynal Abedin; Mustafizur Rahman; Tasnim Azim; Goutam Podder; Badrul Munir Sohel; Abdullah Brooks; Alicia M Fry; Marc-Alain Widdowson; Joseph Bresee; Mahmudur Rahman; Eduardo Azziz-Baumgartner

doi:10.2471/BLT.11.095653

Influenza-associated mortality in 2009 in four sentinel sites in Bangladesh

Nusrat Homaira, Stephen P Luby, A S M Alamgir, Kariul Islam, Repon Paul, Jaynal Abedin, Mustafizur Rahman, Tasnim Azim, Goutam Podder, Badrul Munir Sohel, Abdullah Brooks, Alicia M Fry, Marc-Alain Widdowson, Joseph Bresee, Mahmudur Rahman, Eduardo Azziz-Baumgartner

Institute of Tropical Medicine

Research output: Contribution to journal › A1: Web of Science-article › peer-review

Abstract

OBJECTIVE: To estimate influenza-associated mortality in Bangladesh in 2009.

METHODS: In four hospitals in Bangladesh, respiratory samples were collected twice a month throughout 2009 from inpatients aged < 5 years with severe pneumonia and from older inpatients with severe acute respiratory infection. The samples were tested for influenza virus ribonucleic acid (RNA) using polymerase chain reaction. The deaths in 2009 in five randomly selected unions (the smallest administrative units in Bangladesh) in each hospital's catchment area were then investigated using formal records and informal group discussions. The deaths of those who had reportedly died within 14 days of suddenly developing fever with cough and/or a sore throat were assumed to be influenza-associated. The rate of such deaths in 2009 in each of the catchment areas was then estimated from the number of apparently influenza-associated deaths in the sampled unions, the proportion of the sampled inpatients in the local hospital who tested positive for influenza virus RNA, and the estimated number of residents of the sampled unions.

FINDINGS: Of the 2500 people known to have died in 2009 in all 20 study unions, 346 (14%) reportedly had fever with cough and/or sore throat within 14 days of their deaths. The estimated mean annual influenza-associated mortality in these unions was 11 per 100,000 population: 1.5, 4.0 and 125 deaths per 100,000 among those aged < 5, 5-59 and > 59 years, respectively.

CONCLUSION: The highest burden of influenza-associated mortality in Bangladesh in 2009 was among the elderly.

Original language	English
Journal	Bulletin of the World Health Organization
Volume	90
Issue number	4
Pages (from-to)	272-278
Number of pages	7
ISSN	0042-9686
DOIs	https://doi.org/10.2471/BLT.11.095653
Publication status	Published - 2012

Keywords

Adolescent
Adult
Age Distribution
Bangladesh/epidemiology
Cause of Death
Child
Child, Preschool
Hospitalization/statistics & numerical data
Humans
Influenza, Human/mortality
Middle Aged
Orthomyxoviridae/isolation & purification
Pneumonia/mortality
Respiratory Tract Diseases/mortality
Sentinel Surveillance
Young Adult

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10.2471/BLT.11.095653

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Homaira, N., Luby, S. P., Alamgir, A. S. M., Islam, K., Paul, R., Abedin, J., Rahman, M., Azim, T., Podder, G., Sohel, B. M., Brooks, A., Fry, A. M., Widdowson, M-A., Bresee, J., Rahman, M., & Azziz-Baumgartner, E. (2012). Influenza-associated mortality in 2009 in four sentinel sites in Bangladesh. Bulletin of the World Health Organization, 90(4), 272-278. https://doi.org/10.2471/BLT.11.095653

Homaira, Nusrat ; Luby, Stephen P ; Alamgir, A S M ; Islam, Kariul ; Paul, Repon ; Abedin, Jaynal ; Rahman, Mustafizur ; Azim, Tasnim ; Podder, Goutam ; Sohel, Badrul Munir ; Brooks, Abdullah ; Fry, Alicia M ; Widdowson, Marc-Alain ; Bresee, Joseph ; Rahman, Mahmudur ; Azziz-Baumgartner, Eduardo. / Influenza-associated mortality in 2009 in four sentinel sites in Bangladesh. In: Bulletin of the World Health Organization. 2012 ; Vol. 90, No. 4. pp. 272-278.

@article{fddcbcbdcd8c4605a207b0b8cf3f8c9b,

title = "Influenza-associated mortality in 2009 in four sentinel sites in Bangladesh",

abstract = "OBJECTIVE: To estimate influenza-associated mortality in Bangladesh in 2009.METHODS: In four hospitals in Bangladesh, respiratory samples were collected twice a month throughout 2009 from inpatients aged < 5 years with severe pneumonia and from older inpatients with severe acute respiratory infection. The samples were tested for influenza virus ribonucleic acid (RNA) using polymerase chain reaction. The deaths in 2009 in five randomly selected unions (the smallest administrative units in Bangladesh) in each hospital's catchment area were then investigated using formal records and informal group discussions. The deaths of those who had reportedly died within 14 days of suddenly developing fever with cough and/or a sore throat were assumed to be influenza-associated. The rate of such deaths in 2009 in each of the catchment areas was then estimated from the number of apparently influenza-associated deaths in the sampled unions, the proportion of the sampled inpatients in the local hospital who tested positive for influenza virus RNA, and the estimated number of residents of the sampled unions.FINDINGS: Of the 2500 people known to have died in 2009 in all 20 study unions, 346 (14%) reportedly had fever with cough and/or sore throat within 14 days of their deaths. The estimated mean annual influenza-associated mortality in these unions was 11 per 100,000 population: 1.5, 4.0 and 125 deaths per 100,000 among those aged < 5, 5-59 and > 59 years, respectively.CONCLUSION: The highest burden of influenza-associated mortality in Bangladesh in 2009 was among the elderly.",

keywords = "Adolescent, Adult, Age Distribution, Bangladesh/epidemiology, Cause of Death, Child, Child, Preschool, Hospitalization/statistics & numerical data, Humans, Influenza, Human/mortality, Middle Aged, Orthomyxoviridae/isolation & purification, Pneumonia/mortality, Respiratory Tract Diseases/mortality, Sentinel Surveillance, Young Adult",

author = "Nusrat Homaira and Luby, {Stephen P} and Alamgir, {A S M} and Kariul Islam and Repon Paul and Jaynal Abedin and Mustafizur Rahman and Tasnim Azim and Goutam Podder and Sohel, {Badrul Munir} and Abdullah Brooks and Fry, {Alicia M} and Marc-Alain Widdowson and Joseph Bresee and Mahmudur Rahman and Eduardo Azziz-Baumgartner",

year = "2012",

doi = "10.2471/BLT.11.095653",

language = "English",

volume = "90",

pages = "272--278",

journal = "Bulletin of the World Health Organization",

issn = "0042-9686",

publisher = "World Health Organization",

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Homaira, N, Luby, SP, Alamgir, ASM, Islam, K, Paul, R, Abedin, J, Rahman, M, Azim, T, Podder, G, Sohel, BM, Brooks, A, Fry, AM, Widdowson, M-A, Bresee, J, Rahman, M & Azziz-Baumgartner, E 2012, 'Influenza-associated mortality in 2009 in four sentinel sites in Bangladesh', Bulletin of the World Health Organization, vol. 90, no. 4, pp. 272-278. https://doi.org/10.2471/BLT.11.095653

Influenza-associated mortality in 2009 in four sentinel sites in Bangladesh. / Homaira, Nusrat; Luby, Stephen P; Alamgir, A S M; Islam, Kariul; Paul, Repon; Abedin, Jaynal; Rahman, Mustafizur; Azim, Tasnim; Podder, Goutam; Sohel, Badrul Munir; Brooks, Abdullah; Fry, Alicia M; Widdowson, Marc-Alain; Bresee, Joseph; Rahman, Mahmudur; Azziz-Baumgartner, Eduardo.

In: Bulletin of the World Health Organization, Vol. 90, No. 4, 2012, p. 272-278.

Research output: Contribution to journal › A1: Web of Science-article › peer-review

TY - JOUR

T1 - Influenza-associated mortality in 2009 in four sentinel sites in Bangladesh

AU - Homaira, Nusrat

AU - Luby, Stephen P

AU - Alamgir, A S M

AU - Islam, Kariul

AU - Paul, Repon

AU - Abedin, Jaynal

AU - Rahman, Mustafizur

AU - Azim, Tasnim

AU - Podder, Goutam

AU - Sohel, Badrul Munir

AU - Brooks, Abdullah

AU - Fry, Alicia M

AU - Widdowson, Marc-Alain

AU - Bresee, Joseph

AU - Rahman, Mahmudur

AU - Azziz-Baumgartner, Eduardo

PY - 2012

Y1 - 2012

N2 - OBJECTIVE: To estimate influenza-associated mortality in Bangladesh in 2009.METHODS: In four hospitals in Bangladesh, respiratory samples were collected twice a month throughout 2009 from inpatients aged < 5 years with severe pneumonia and from older inpatients with severe acute respiratory infection. The samples were tested for influenza virus ribonucleic acid (RNA) using polymerase chain reaction. The deaths in 2009 in five randomly selected unions (the smallest administrative units in Bangladesh) in each hospital's catchment area were then investigated using formal records and informal group discussions. The deaths of those who had reportedly died within 14 days of suddenly developing fever with cough and/or a sore throat were assumed to be influenza-associated. The rate of such deaths in 2009 in each of the catchment areas was then estimated from the number of apparently influenza-associated deaths in the sampled unions, the proportion of the sampled inpatients in the local hospital who tested positive for influenza virus RNA, and the estimated number of residents of the sampled unions.FINDINGS: Of the 2500 people known to have died in 2009 in all 20 study unions, 346 (14%) reportedly had fever with cough and/or sore throat within 14 days of their deaths. The estimated mean annual influenza-associated mortality in these unions was 11 per 100,000 population: 1.5, 4.0 and 125 deaths per 100,000 among those aged < 5, 5-59 and > 59 years, respectively.CONCLUSION: The highest burden of influenza-associated mortality in Bangladesh in 2009 was among the elderly.

AB - OBJECTIVE: To estimate influenza-associated mortality in Bangladesh in 2009.METHODS: In four hospitals in Bangladesh, respiratory samples were collected twice a month throughout 2009 from inpatients aged < 5 years with severe pneumonia and from older inpatients with severe acute respiratory infection. The samples were tested for influenza virus ribonucleic acid (RNA) using polymerase chain reaction. The deaths in 2009 in five randomly selected unions (the smallest administrative units in Bangladesh) in each hospital's catchment area were then investigated using formal records and informal group discussions. The deaths of those who had reportedly died within 14 days of suddenly developing fever with cough and/or a sore throat were assumed to be influenza-associated. The rate of such deaths in 2009 in each of the catchment areas was then estimated from the number of apparently influenza-associated deaths in the sampled unions, the proportion of the sampled inpatients in the local hospital who tested positive for influenza virus RNA, and the estimated number of residents of the sampled unions.FINDINGS: Of the 2500 people known to have died in 2009 in all 20 study unions, 346 (14%) reportedly had fever with cough and/or sore throat within 14 days of their deaths. The estimated mean annual influenza-associated mortality in these unions was 11 per 100,000 population: 1.5, 4.0 and 125 deaths per 100,000 among those aged < 5, 5-59 and > 59 years, respectively.CONCLUSION: The highest burden of influenza-associated mortality in Bangladesh in 2009 was among the elderly.

KW - Adolescent

KW - Adult

KW - Age Distribution

KW - Bangladesh/epidemiology

KW - Cause of Death

KW - Child

KW - Child, Preschool

KW - Hospitalization/statistics & numerical data

KW - Humans

KW - Influenza, Human/mortality

KW - Middle Aged

KW - Orthomyxoviridae/isolation & purification

KW - Pneumonia/mortality

KW - Respiratory Tract Diseases/mortality

KW - Sentinel Surveillance

KW - Young Adult

U2 - 10.2471/BLT.11.095653

DO - 10.2471/BLT.11.095653

M3 - A1: Web of Science-article

C2 - 22511823

VL - 90

SP - 272

EP - 278

JO - Bulletin of the World Health Organization

JF - Bulletin of the World Health Organization

SN - 0042-9686

IS - 4

ER -

Influenza-associated mortality in 2009 in four sentinel sites in Bangladesh

Abstract

Keywords

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