Injectable progestin-only contraception is associated with increased levels of pro-inflammatory cytokines in the female genital tract

Jennifer Deese, Lindi Masson, William Miller, Myron Cohen, Charles Morrison, Meng Wang, Khatija Ahmed, Kawango Agot, Tania Crucitti, Saïd Abdellati, Lut Van Damme

    Research output: Contribution to journalA1: Web of Science-article

    Abstract

    PROBLEM: Genital inflammatory changes may be a mechanism of increased HIV risk among injectable progestin-only contraception (IPC) users.

    METHOD OF STUDY: We conducted a cross-sectional analysis of 376 Kenyan and South African women. Genital cytokines and secretory leukocyte peptidase inhibitor concentrations in a reference population were compared to IPC users and women with reproductive tract infections.

    RESULTS: No significant variability in marker concentrations was observed by age or site. Depot medroxyprogesterone acetate (DMPA) users had significantly higher MIP-1α, MIP-1β, IL-6, IL-8, IP-10, and RANTES concentrations. Norethisterone oenanthate users had significantly higher IL-6, IL-8, and RANTES concentrations. Women with sexually transmitted infections had variable inflammation, and women with bacterial vaginosis exhibited a mixed profile of up and downregulation.

    CONCLUSION: The finding of substantial mucosal inflammation among DMPA users provides evidence which, combined with the results of prior studies, suggests that DMPA may create an immune environment conducive to HIV target cell recruitment and inhibitory for antiviral activity.

    Original languageEnglish
    JournalAmerican Journal of Reproductive Immunology
    Volume74
    Issue number4
    Pages (from-to)357-367
    Number of pages11
    ISSN1046-7408
    DOIs
    Publication statusPublished - 2015

    Fingerprint

    Dive into the research topics of 'Injectable progestin-only contraception is associated with increased levels of pro-inflammatory cytokines in the female genital tract'. Together they form a unique fingerprint.

    Cite this