Injectable progestin-only contraception is associated with increased levels of pro-inflammatory cytokines in the female genital tract

Jennifer Deese; Lindi Masson; William Miller; Myron Cohen; Charles Morrison; Meng Wang; Khatija Ahmed; Kawango Agot; Tania Crucitti; Saïd Abdellati; Lut Van Damme

doi:10.1111/aji.12415

Injectable progestin-only contraception is associated with increased levels of pro-inflammatory cytokines in the female genital tract

Jennifer Deese, Lindi Masson, William Miller, Myron Cohen, Charles Morrison, Meng Wang, Khatija Ahmed, Kawango Agot, Tania Crucitti, Saïd Abdellati, Lut Van Damme

Research output: Contribution to journal › A1: Web of Science-article › peer-review

Abstract

PROBLEM: Genital inflammatory changes may be a mechanism of increased HIV risk among injectable progestin-only contraception (IPC) users.

METHOD OF STUDY: We conducted a cross-sectional analysis of 376 Kenyan and South African women. Genital cytokines and secretory leukocyte peptidase inhibitor concentrations in a reference population were compared to IPC users and women with reproductive tract infections.

RESULTS: No significant variability in marker concentrations was observed by age or site. Depot medroxyprogesterone acetate (DMPA) users had significantly higher MIP-1α, MIP-1β, IL-6, IL-8, IP-10, and RANTES concentrations. Norethisterone oenanthate users had significantly higher IL-6, IL-8, and RANTES concentrations. Women with sexually transmitted infections had variable inflammation, and women with bacterial vaginosis exhibited a mixed profile of up and downregulation.

CONCLUSION: The finding of substantial mucosal inflammation among DMPA users provides evidence which, combined with the results of prior studies, suggests that DMPA may create an immune environment conducive to HIV target cell recruitment and inhibitory for antiviral activity.

Original language	English
Journal	American Journal of Reproductive Immunology
Volume	74
Issue number	4
Pages (from-to)	357-367
Number of pages	11
ISSN	1046-7408
DOIs	https://doi.org/10.1111/aji.12415
Publication status	Published - 2015

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Deese, J., Masson, L., Miller, W., Cohen, M., Morrison, C., Wang, M., Ahmed, K., Agot, K., Crucitti, T., Abdellati, S., & Van Damme, L. (2015). Injectable progestin-only contraception is associated with increased levels of pro-inflammatory cytokines in the female genital tract. American Journal of Reproductive Immunology, 74(4), 357-367. https://doi.org/10.1111/aji.12415

@article{108d5ff92b6b4e61bc212e000365e11e,

title = "Injectable progestin-only contraception is associated with increased levels of pro-inflammatory cytokines in the female genital tract",

abstract = "PROBLEM: Genital inflammatory changes may be a mechanism of increased HIV risk among injectable progestin-only contraception (IPC) users.METHOD OF STUDY: We conducted a cross-sectional analysis of 376 Kenyan and South African women. Genital cytokines and secretory leukocyte peptidase inhibitor concentrations in a reference population were compared to IPC users and women with reproductive tract infections.RESULTS: No significant variability in marker concentrations was observed by age or site. Depot medroxyprogesterone acetate (DMPA) users had significantly higher MIP-1α, MIP-1β, IL-6, IL-8, IP-10, and RANTES concentrations. Norethisterone oenanthate users had significantly higher IL-6, IL-8, and RANTES concentrations. Women with sexually transmitted infections had variable inflammation, and women with bacterial vaginosis exhibited a mixed profile of up and downregulation.CONCLUSION: The finding of substantial mucosal inflammation among DMPA users provides evidence which, combined with the results of prior studies, suggests that DMPA may create an immune environment conducive to HIV target cell recruitment and inhibitory for antiviral activity.",

author = "Jennifer Deese and Lindi Masson and William Miller and Myron Cohen and Charles Morrison and Meng Wang and Khatija Ahmed and Kawango Agot and Tania Crucitti and Sa{\"i}d Abdellati and {Van Damme}, Lut",

note = "{\textcopyright} 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.",

year = "2015",

doi = "10.1111/aji.12415",

language = "English",

volume = "74",

pages = "357--367",

journal = "American Journal of Reproductive Immunology",

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Deese, J, Masson, L, Miller, W, Cohen, M, Morrison, C, Wang, M, Ahmed, K, Agot, K, Crucitti, T, Abdellati, S & Van Damme, L 2015, 'Injectable progestin-only contraception is associated with increased levels of pro-inflammatory cytokines in the female genital tract', American Journal of Reproductive Immunology, vol. 74, no. 4, pp. 357-367. https://doi.org/10.1111/aji.12415

TY - JOUR

T1 - Injectable progestin-only contraception is associated with increased levels of pro-inflammatory cytokines in the female genital tract

AU - Deese, Jennifer

AU - Masson, Lindi

AU - Miller, William

AU - Cohen, Myron

AU - Morrison, Charles

AU - Wang, Meng

AU - Ahmed, Khatija

AU - Agot, Kawango

AU - Crucitti, Tania

AU - Abdellati, Saïd

AU - Van Damme, Lut

PY - 2015

Y1 - 2015

N2 - PROBLEM: Genital inflammatory changes may be a mechanism of increased HIV risk among injectable progestin-only contraception (IPC) users.METHOD OF STUDY: We conducted a cross-sectional analysis of 376 Kenyan and South African women. Genital cytokines and secretory leukocyte peptidase inhibitor concentrations in a reference population were compared to IPC users and women with reproductive tract infections.RESULTS: No significant variability in marker concentrations was observed by age or site. Depot medroxyprogesterone acetate (DMPA) users had significantly higher MIP-1α, MIP-1β, IL-6, IL-8, IP-10, and RANTES concentrations. Norethisterone oenanthate users had significantly higher IL-6, IL-8, and RANTES concentrations. Women with sexually transmitted infections had variable inflammation, and women with bacterial vaginosis exhibited a mixed profile of up and downregulation.CONCLUSION: The finding of substantial mucosal inflammation among DMPA users provides evidence which, combined with the results of prior studies, suggests that DMPA may create an immune environment conducive to HIV target cell recruitment and inhibitory for antiviral activity.

AB - PROBLEM: Genital inflammatory changes may be a mechanism of increased HIV risk among injectable progestin-only contraception (IPC) users.METHOD OF STUDY: We conducted a cross-sectional analysis of 376 Kenyan and South African women. Genital cytokines and secretory leukocyte peptidase inhibitor concentrations in a reference population were compared to IPC users and women with reproductive tract infections.RESULTS: No significant variability in marker concentrations was observed by age or site. Depot medroxyprogesterone acetate (DMPA) users had significantly higher MIP-1α, MIP-1β, IL-6, IL-8, IP-10, and RANTES concentrations. Norethisterone oenanthate users had significantly higher IL-6, IL-8, and RANTES concentrations. Women with sexually transmitted infections had variable inflammation, and women with bacterial vaginosis exhibited a mixed profile of up and downregulation.CONCLUSION: The finding of substantial mucosal inflammation among DMPA users provides evidence which, combined with the results of prior studies, suggests that DMPA may create an immune environment conducive to HIV target cell recruitment and inhibitory for antiviral activity.

U2 - 10.1111/aji.12415

DO - 10.1111/aji.12415

M3 - A1: Web of Science-article

C2 - 26202107

SN - 1046-7408

VL - 74

SP - 357

EP - 367

JO - American Journal of Reproductive Immunology

JF - American Journal of Reproductive Immunology

IS - 4

ER -

Injectable progestin-only contraception is associated with increased levels of pro-inflammatory cytokines in the female genital tract

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