Innate immunity in the tsetse fly (Glossina), vector of African trypanosomes

Irina Matetovici, Linda De Vooght, Jan Van den Abbeele

Research output: Contribution to journalA1: Web of Science-article

Abstract

Tsetse flies (Glossina sp.) are medically and veterinary important vectors of African trypanosomes, protozoan parasites that cause devastating diseases in humans and livestock in sub-Saharan Africa. These flies feed exclusively on vertebrate blood and harbor a limited diversity of obligate and facultative bacterial commensals. They have a well-developed innate immune system that plays a key role in protecting the fly against invading pathogens and in modulating the fly's ability to transmit African trypanosomes. In this review, we briefly summarize our current knowledge on the tsetse fly innate immune system and its interaction with the bacterial commensals and the trypanosome parasite.

Original languageEnglish
JournalDevelopmental and Comparative Immunology
Volume98
Pages (from-to)181-188
Number of pages8
ISSN0145-305X
DOIs
Publication statusPublished - 2019

Keywords

  • Innate immunity
  • Tsetse fly
  • Vector
  • African trypanosomiasis
  • Tsetse-trypanosome interactions
  • PEPTIDOGLYCAN RECOGNITION PROTEINS
  • PGRP-LB
  • MORSITANS-MORSITANS
  • MIDGUT
  • EXPRESSION
  • INFECTION
  • BACTERIAL
  • TRANSMISSION
  • RESPONSES
  • GENES

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