Intermediate susceptibility to ciprofloxacin among Salmonella enterica serovar Typhi isolates in Lima, Peru

Coralith García; Veerle Lejon; Gertrudis Horna; Lizeth Astocondor; Raymond Vanhoof; Sophie Bertrand; Jan Jacobs

doi:10.1128/JCM.02663-13

Intermediate susceptibility to ciprofloxacin among Salmonella enterica serovar Typhi isolates in Lima, Peru

Coralith García, Veerle Lejon, Gertrudis Horna, Lizeth Astocondor, Raymond Vanhoof, Sophie Bertrand, Jan Jacobs

Tropical Bacteriology

Research output: Contribution to journal › A1: Web of Science-article › peer-review

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Abstract

Thirty-three Salmonella enterica serovar Typhi blood isolates from Lima, Peru (2008 to 2012), were fully susceptible to trimethoprim-sulfamethoxazole, chloramphenicol, ceftriaxone, and tetracycline; 8/33 (24.2%) showed intermediate susceptibility to ciprofloxacin carrying mutations in the quinolone resistance-determining region of the gyrA gene (Ser83-Phe and Asp87-Asn) and in the gyrB gene (Ser464-Phe).

Original language	English
Journal	Journal of Clinical Microbiology
Volume	52
Issue number	3
Pages (from-to)	968-970
Number of pages	3
ISSN	0095-1137
DOIs	https://doi.org/10.1128/JCM.02663-13
Publication status	Published - 2014

Keywords

Adolescent
Adult
Animals
Anti-Bacterial Agents
Blood
Child
Child, Preschool
Ciprofloxacin
DNA Gyrase
Drug Resistance, Bacterial
Female
Genotype
Humans
Male
Microbial Sensitivity Tests
Mutation, Missense
Peru
Salmonella typhi
Typhoid Fever
Young Adult

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10.1128/JCM.02663-13

2014jcmi0968Final published version, 504 KB

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title = "Intermediate susceptibility to ciprofloxacin among Salmonella enterica serovar Typhi isolates in Lima, Peru",

abstract = "Thirty-three Salmonella enterica serovar Typhi blood isolates from Lima, Peru (2008 to 2012), were fully susceptible to trimethoprim-sulfamethoxazole, chloramphenicol, ceftriaxone, and tetracycline; 8/33 (24.2%) showed intermediate susceptibility to ciprofloxacin carrying mutations in the quinolone resistance-determining region of the gyrA gene (Ser83-Phe and Asp87-Asn) and in the gyrB gene (Ser464-Phe).",

keywords = "Adolescent, Adult, Animals, Anti-Bacterial Agents, Blood, Child, Child, Preschool, Ciprofloxacin, DNA Gyrase, Drug Resistance, Bacterial, Female, Genotype, Humans, Male, Microbial Sensitivity Tests, Mutation, Missense, Peru, Salmonella typhi, Typhoid Fever, Young Adult",

author = "Coralith Garc{\'i}a and Veerle Lejon and Gertrudis Horna and Lizeth Astocondor and Raymond Vanhoof and Sophie Bertrand and Jan Jacobs",

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TY - JOUR

T1 - Intermediate susceptibility to ciprofloxacin among Salmonella enterica serovar Typhi isolates in Lima, Peru

AU - García, Coralith

AU - Lejon, Veerle

AU - Horna, Gertrudis

AU - Astocondor, Lizeth

AU - Vanhoof, Raymond

AU - Bertrand, Sophie

AU - Jacobs, Jan

N1 - FTX

PY - 2014

Y1 - 2014

N2 - Thirty-three Salmonella enterica serovar Typhi blood isolates from Lima, Peru (2008 to 2012), were fully susceptible to trimethoprim-sulfamethoxazole, chloramphenicol, ceftriaxone, and tetracycline; 8/33 (24.2%) showed intermediate susceptibility to ciprofloxacin carrying mutations in the quinolone resistance-determining region of the gyrA gene (Ser83-Phe and Asp87-Asn) and in the gyrB gene (Ser464-Phe).

AB - Thirty-three Salmonella enterica serovar Typhi blood isolates from Lima, Peru (2008 to 2012), were fully susceptible to trimethoprim-sulfamethoxazole, chloramphenicol, ceftriaxone, and tetracycline; 8/33 (24.2%) showed intermediate susceptibility to ciprofloxacin carrying mutations in the quinolone resistance-determining region of the gyrA gene (Ser83-Phe and Asp87-Asn) and in the gyrB gene (Ser464-Phe).

KW - Adolescent

KW - Adult

KW - Animals

KW - Anti-Bacterial Agents

KW - Blood

KW - Child

KW - Child, Preschool

KW - Ciprofloxacin

KW - DNA Gyrase

KW - Drug Resistance, Bacterial

KW - Female

KW - Genotype

KW - Humans

KW - Male

KW - Microbial Sensitivity Tests

KW - Mutation, Missense

KW - Peru

KW - Salmonella typhi

KW - Typhoid Fever

KW - Young Adult

U2 - 10.1128/JCM.02663-13

DO - 10.1128/JCM.02663-13

M3 - A1: Web of Science-article

C2 - 24371234

SN - 0095-1137

VL - 52

SP - 968

EP - 970

JO - Journal of Clinical Microbiology

JF - Journal of Clinical Microbiology

IS - 3

ER -

Intermediate susceptibility to ciprofloxacin among Salmonella enterica serovar Typhi isolates in Lima, Peru

Abstract

Keywords

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