Intermediate susceptibility to ciprofloxacin among Salmonella enterica serovar Typhi isolates in Lima, Peru

Coralith García, Veerle Lejon, Gertrudis Horna, Lizeth Astocondor, Raymond Vanhoof, Sophie Bertrand, Jan Jacobs

Research output: Contribution to journalA1: Web of Science-article

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Abstract

Thirty-three Salmonella enterica serovar Typhi blood isolates from Lima, Peru (2008 to 2012), were fully susceptible to trimethoprim-sulfamethoxazole, chloramphenicol, ceftriaxone, and tetracycline; 8/33 (24.2%) showed intermediate susceptibility to ciprofloxacin carrying mutations in the quinolone resistance-determining region of the gyrA gene (Ser83-Phe and Asp87-Asn) and in the gyrB gene (Ser464-Phe).

Original languageEnglish
JournalJournal of Clinical Microbiology
Volume52
Issue number3
Pages (from-to)968-970
Number of pages3
ISSN0095-1137
DOIs
Publication statusPublished - 2014

Keywords

  • Adolescent
  • Adult
  • Animals
  • Anti-Bacterial Agents
  • Blood
  • Child
  • Child, Preschool
  • Ciprofloxacin
  • DNA Gyrase
  • Drug Resistance, Bacterial
  • Female
  • Genotype
  • Humans
  • Male
  • Microbial Sensitivity Tests
  • Mutation, Missense
  • Peru
  • Salmonella typhi
  • Typhoid Fever
  • Young Adult

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