Interruption or deferral of antiretroviral therapy reduces markers of bone turnover compared with continuous therapy: The SMART Body Composition substudy

J. Hoy; B. Grund; M. Roediger; K.E. Ensrud; I. Brar; R. Colebunders; N. De Castro; M. Johnson; A. Sharma; A. Carr

doi:10.1002/jbmr.1861

Interruption or deferral of antiretroviral therapy reduces markers of bone turnover compared with continuous therapy: The SMART Body Composition substudy

J. Hoy, B. Grund, M. Roediger, K.E. Ensrud, I. Brar, R. Colebunders, N. De Castro, M. Johnson, A. Sharma, A. Carr

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Abstract

Bone mineral density (BMD) declines significantly in HIV patients on antiretroviral therapy (ART). We compared the effects of intermittent versus continuous ART on markers of bone turnover in the Body Composition substudy of the Strategies for Management of AntiRetroviral Therapy (SMART) trial and determined whether early changes in markers predicted subsequent change in BMD. For 202 participants (median age 44 years, 17% female, 74% on ART) randomised to continuous or intermittent ART, plasma markers of inflammation and bone turnover were evaluated at baseline, months 4 and 12; BMD at the spine (dual X-ray absorptiometry [DXA] and computed tomography) and hip (DXA) was evaluated annually. Compared to the continuous ART group, mean bone-specific alkaline phosphatase (bALP), osteocalcin, procollagen type 1 N-terminal propeptide (P1NP), N-terminal cross-linking telopeptide of type 1 collagen (NTX), and C-terminal cross-linking telopeptide of type 1 collagen (betaCTX) decreased significantly in the intermittent ART group, whereas RANKL and the RANKL:osteoprotegerin (OPG) ratio increased (all p

Original language	English
Journal	Journal of Bone and Mineral Research
Volume	28
Issue number	6
Pages (from-to)	1264-1274
Number of pages	11
ISSN	0884-0431
DOIs	https://doi.org/10.1002/jbmr.1861
Publication status	Published - 2013

Keywords

Viral diseases
HIV
AIDS
HAART
Antiretrovirals
Health impact
Bone mineral density
Prediction
Intermittent treatment
Inflammation
Alkaline phosphatase
Osteocalcin
Hip
Spine
Follow-up
USA
America-North
Australia
Pacific
Spain
Europe-South

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10.1002/jbmr.1861

2013jbmr1264

http://lib.itg.be/pdf/itg/2013/2013jbmr1264.pdf

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Hoy, J., Grund, B., Roediger, M., Ensrud, K. E., Brar, I., Colebunders, R., De Castro, N., Johnson, M., Sharma, A., & Carr, A. (2013). Interruption or deferral of antiretroviral therapy reduces markers of bone turnover compared with continuous therapy: The SMART Body Composition substudy. Journal of Bone and Mineral Research, 28(6), 1264-1274. https://doi.org/10.1002/jbmr.1861

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title = "Interruption or deferral of antiretroviral therapy reduces markers of bone turnover compared with continuous therapy: The SMART Body Composition substudy",

abstract = "Bone mineral density (BMD) declines significantly in HIV patients on antiretroviral therapy (ART). We compared the effects of intermittent versus continuous ART on markers of bone turnover in the Body Composition substudy of the Strategies for Management of AntiRetroviral Therapy (SMART) trial and determined whether early changes in markers predicted subsequent change in BMD. For 202 participants (median age 44 years, 17% female, 74% on ART) randomised to continuous or intermittent ART, plasma markers of inflammation and bone turnover were evaluated at baseline, months 4 and 12; BMD at the spine (dual X-ray absorptiometry [DXA] and computed tomography) and hip (DXA) was evaluated annually. Compared to the continuous ART group, mean bone-specific alkaline phosphatase (bALP), osteocalcin, procollagen type 1 N-terminal propeptide (P1NP), N-terminal cross-linking telopeptide of type 1 collagen (NTX), and C-terminal cross-linking telopeptide of type 1 collagen (betaCTX) decreased significantly in the intermittent ART group, whereas RANKL and the RANKL:osteoprotegerin (OPG) ratio increased (all p",

keywords = "Viral diseases, HIV, AIDS, HAART, Antiretrovirals, Health impact, Bone mineral density, Prediction, Intermittent treatment, Inflammation, Alkaline phosphatase, Osteocalcin, Hip, Spine, Follow-up, USA, America-North, Australia, Pacific, Spain, Europe-South",

author = "J. Hoy and B. Grund and M. Roediger and K.E. Ensrud and I. Brar and R. Colebunders and {De Castro}, N. and M. Johnson and A. Sharma and A. Carr",

note = "FTX; ITG-C6A; DCS; U-HIVCLI; JIF; DOI; PDF; Abstract; DSPACE56",

year = "2013",

doi = "10.1002/jbmr.1861",

language = "English",

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Hoy, J, Grund, B, Roediger, M, Ensrud, KE, Brar, I, Colebunders, R, De Castro, N, Johnson, M, Sharma, A & Carr, A 2013, 'Interruption or deferral of antiretroviral therapy reduces markers of bone turnover compared with continuous therapy: The SMART Body Composition substudy', Journal of Bone and Mineral Research, vol. 28, no. 6, pp. 1264-1274. https://doi.org/10.1002/jbmr.1861

TY - JOUR

T1 - Interruption or deferral of antiretroviral therapy reduces markers of bone turnover compared with continuous therapy: The SMART Body Composition substudy

AU - Hoy, J.

AU - Grund, B.

AU - Roediger, M.

AU - Ensrud, K.E.

AU - Brar, I.

AU - Colebunders, R.

AU - De Castro, N.

AU - Johnson, M.

AU - Sharma, A.

AU - Carr, A.

N1 - FTX; ITG-C6A; DCS; U-HIVCLI; JIF; DOI; PDF; Abstract; DSPACE56

PY - 2013

Y1 - 2013

N2 - Bone mineral density (BMD) declines significantly in HIV patients on antiretroviral therapy (ART). We compared the effects of intermittent versus continuous ART on markers of bone turnover in the Body Composition substudy of the Strategies for Management of AntiRetroviral Therapy (SMART) trial and determined whether early changes in markers predicted subsequent change in BMD. For 202 participants (median age 44 years, 17% female, 74% on ART) randomised to continuous or intermittent ART, plasma markers of inflammation and bone turnover were evaluated at baseline, months 4 and 12; BMD at the spine (dual X-ray absorptiometry [DXA] and computed tomography) and hip (DXA) was evaluated annually. Compared to the continuous ART group, mean bone-specific alkaline phosphatase (bALP), osteocalcin, procollagen type 1 N-terminal propeptide (P1NP), N-terminal cross-linking telopeptide of type 1 collagen (NTX), and C-terminal cross-linking telopeptide of type 1 collagen (betaCTX) decreased significantly in the intermittent ART group, whereas RANKL and the RANKL:osteoprotegerin (OPG) ratio increased (all p

AB - Bone mineral density (BMD) declines significantly in HIV patients on antiretroviral therapy (ART). We compared the effects of intermittent versus continuous ART on markers of bone turnover in the Body Composition substudy of the Strategies for Management of AntiRetroviral Therapy (SMART) trial and determined whether early changes in markers predicted subsequent change in BMD. For 202 participants (median age 44 years, 17% female, 74% on ART) randomised to continuous or intermittent ART, plasma markers of inflammation and bone turnover were evaluated at baseline, months 4 and 12; BMD at the spine (dual X-ray absorptiometry [DXA] and computed tomography) and hip (DXA) was evaluated annually. Compared to the continuous ART group, mean bone-specific alkaline phosphatase (bALP), osteocalcin, procollagen type 1 N-terminal propeptide (P1NP), N-terminal cross-linking telopeptide of type 1 collagen (NTX), and C-terminal cross-linking telopeptide of type 1 collagen (betaCTX) decreased significantly in the intermittent ART group, whereas RANKL and the RANKL:osteoprotegerin (OPG) ratio increased (all p

KW - Viral diseases

KW - HIV

KW - AIDS

KW - HAART

KW - Antiretrovirals

KW - Health impact

KW - Bone mineral density

KW - Prediction

KW - Intermittent treatment

KW - Inflammation

KW - Alkaline phosphatase

KW - Osteocalcin

KW - Hip

KW - Spine

KW - Follow-up

KW - USA

KW - America-North

KW - Australia

KW - Pacific

KW - Spain

KW - Europe-South

U2 - 10.1002/jbmr.1861

DO - 10.1002/jbmr.1861

M3 - A1: Web of Science-article

C2 - 23299909

SN - 0884-0431

VL - 28

SP - 1264

EP - 1274

JO - Journal of Bone and Mineral Research

JF - Journal of Bone and Mineral Research

IS - 6

ER -

Interruption or deferral of antiretroviral therapy reduces markers of bone turnover compared with continuous therapy: The SMART Body Composition substudy

Abstract

Keywords

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