Introduction of HIV-2 and multiple HIV-1 subtypes to Lebanon

D Pieniazek; J Baggs; DJ Hu; GM Matar; AM Abdelnoor; JE Mokhbat; M Uwaydah; AR Bizri; A Ramos; LM Janini; A Tanuri; C Fridlund; C Schable; L Heyndrickx; MA Rayfield; W Heneine

doi:10.3201/eid0404.980418

Introduction of HIV-2 and multiple HIV-1 subtypes to Lebanon

D Pieniazek, J Baggs, DJ Hu, GM Matar, AM Abdelnoor, JE Mokhbat, M Uwaydah, AR Bizri, A Ramos, LM Janini, A Tanuri, C Fridlund, C Schable, L Heyndrickx, MA Rayfield, W Heneine

Virology

Research output: Contribution to journal › A1: Web of Science-article › peer-review

Abstract

HIV genetic variability, phylogenetic relationships, and transmission dynamics were analyzed in 26 HIV-infected patients from Lebanon. Twenty-five specimens were identified as HIV-1 and one as HIV-2 subtype B. The 25 strains were classified into six env-C2-V3 HIV-1 subtypes: B (n = 10), A (n = 11), C (n = 1), D (n = 1), G (n = 1), and unclassifiable. Potential recombinants combining parts of viral regions from different subtypes A^env/D^pol/A^gag, G^env/A^pol and the unclassifiable-subtype^env/ unclassifiable-subtype^pol/A^gag were found in three patients. Epidemiologic analysis of travel histories and behavioral risks indicated that HIV-1 and HIV-2 subtypes reflected HIV strains prevalent in countries visited by patients or their sex partners. Spread of complex HIV-subtype distribution patterns to regions where HIV is not endemic may be more common than previously thought. Blood screening for both HIV-1 and HIV-2 in Lebanon is recommended to protect the blood supply. HIV subtype data provide information for vaccine development.

Original language	English
Journal	Emerging Infectious Diseases
Volume	4
Issue number	4
Pages (from-to)	649-656
Number of pages	8
ISSN	1080-6040
DOIs	https://doi.org/10.3201/eid0404.980418
Publication status	Published - 1998

Keywords

B780-tropical-medicine
Virology
HIV-2
HIV-1
Subtypes
Viral diseases
Epidemiology
Lebanon
Middle East
Asia-West

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10.3201/eid0404.980418Licence: CC BY

http://lib.itg.be/pdf/itg/1998/1998eidi0649.pdf

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title = "Introduction of HIV-2 and multiple HIV-1 subtypes to Lebanon",

abstract = "HIV genetic variability, phylogenetic relationships, and transmission dynamics were analyzed in 26 HIV-infected patients from Lebanon. Twenty-five specimens were identified as HIV-1 and one as HIV-2 subtype B. The 25 strains were classified into six env-C2-V3 HIV-1 subtypes: B (n = 10), A (n = 11), C (n = 1), D (n = 1), G (n = 1), and unclassifiable. Potential recombinants combining parts of viral regions from different subtypes Aenv/Dpol/Agag, Genv/Apol and the unclassifiable-subtypeenv/ unclassifiable-subtypepol/Agag were found in three patients. Epidemiologic analysis of travel histories and behavioral risks indicated that HIV-1 and HIV-2 subtypes reflected HIV strains prevalent in countries visited by patients or their sex partners. Spread of complex HIV-subtype distribution patterns to regions where HIV is not endemic may be more common than previously thought. Blood screening for both HIV-1 and HIV-2 in Lebanon is recommended to protect the blood supply. HIV subtype data provide information for vaccine development.",

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author = "D Pieniazek and J Baggs and DJ Hu and GM Matar and AM Abdelnoor and JE Mokhbat and M Uwaydah and AR Bizri and A Ramos and LM Janini and A Tanuri and C Fridlund and C Schable and L Heyndrickx and MA Rayfield and W Heneine",

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T1 - Introduction of HIV-2 and multiple HIV-1 subtypes to Lebanon

AU - Pieniazek, D

AU - Baggs, J

AU - Hu, DJ

AU - Matar, GM

AU - Abdelnoor, AM

AU - Mokhbat, JE

AU - Uwaydah, M

AU - Bizri, AR

AU - Ramos, A

AU - Janini, LM

AU - Tanuri, A

AU - Fridlund, C

AU - Schable, C

AU - Heyndrickx, L

AU - Rayfield, MA

AU - Heneine, W

N1 - FTX: (CC BY)

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Y1 - 1998

N2 - HIV genetic variability, phylogenetic relationships, and transmission dynamics were analyzed in 26 HIV-infected patients from Lebanon. Twenty-five specimens were identified as HIV-1 and one as HIV-2 subtype B. The 25 strains were classified into six env-C2-V3 HIV-1 subtypes: B (n = 10), A (n = 11), C (n = 1), D (n = 1), G (n = 1), and unclassifiable. Potential recombinants combining parts of viral regions from different subtypes Aenv/Dpol/Agag, Genv/Apol and the unclassifiable-subtypeenv/ unclassifiable-subtypepol/Agag were found in three patients. Epidemiologic analysis of travel histories and behavioral risks indicated that HIV-1 and HIV-2 subtypes reflected HIV strains prevalent in countries visited by patients or their sex partners. Spread of complex HIV-subtype distribution patterns to regions where HIV is not endemic may be more common than previously thought. Blood screening for both HIV-1 and HIV-2 in Lebanon is recommended to protect the blood supply. HIV subtype data provide information for vaccine development.

AB - HIV genetic variability, phylogenetic relationships, and transmission dynamics were analyzed in 26 HIV-infected patients from Lebanon. Twenty-five specimens were identified as HIV-1 and one as HIV-2 subtype B. The 25 strains were classified into six env-C2-V3 HIV-1 subtypes: B (n = 10), A (n = 11), C (n = 1), D (n = 1), G (n = 1), and unclassifiable. Potential recombinants combining parts of viral regions from different subtypes Aenv/Dpol/Agag, Genv/Apol and the unclassifiable-subtypeenv/ unclassifiable-subtypepol/Agag were found in three patients. Epidemiologic analysis of travel histories and behavioral risks indicated that HIV-1 and HIV-2 subtypes reflected HIV strains prevalent in countries visited by patients or their sex partners. Spread of complex HIV-subtype distribution patterns to regions where HIV is not endemic may be more common than previously thought. Blood screening for both HIV-1 and HIV-2 in Lebanon is recommended to protect the blood supply. HIV subtype data provide information for vaccine development.

KW - B780-tropical-medicine

KW - Virology

KW - HIV-2

KW - HIV-1

KW - Subtypes

KW - Viral diseases

KW - Epidemiology

KW - Lebanon

KW - Middle East

KW - Asia-West

UR - https://www.webofscience.com/wos/woscc/full-record/WOS:000077532500018

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DO - 10.3201/eid0404.980418

M3 - A1: Web of Science-article

SN - 1080-6040

VL - 4

SP - 649

EP - 656

JO - Emerging Infectious Diseases

JF - Emerging Infectious Diseases

IS - 4

ER -

Introduction of HIV-2 and multiple HIV-1 subtypes to Lebanon

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Keywords

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