Iron status of Burkinabe adolescent girls predicts malaria risk in the following rainy season

Loretta Brabin, Stephen A. Roberts, Halidou Tinto, Sabine Gies, Salou Diallo, Bernard Brabin

    Research output: Contribution to journalA1: Web of Science-article

    Abstract

    High levels of storage iron may increase malaria susceptibility. This risk has not been investigated in semi-immune adolescents. We investigated whether baseline iron status of non-pregnant adolescent girls living in a high malaria transmission area in Burkina Faso affected malaria risk during the following rainy season. For this prospective study, we analysed data from an interim safety survey, conducted six months into a randomised iron supplementation trial. We used logistic regression to model the risk of P. falciparum infection prevalence by microscopy, the pre-specified interim safety outcome, in relation to iron status, nutritional indicators and menarche assessed at recruitment. The interim survey was attended by 1223 (82%) of 1486 eligible participants, 1084 (89%) of whom were

    Original languageEnglish
    Article number1446
    JournalNutrients
    Volume12
    Issue number5
    Number of pages15
    ISSN2072-6643
    DOIs
    Publication statusPublished - 2020

    Keywords

    • iron biomarkers
    • malaria
    • adolescent girls
    • menarche
    • body mass index
    • Burkina Faso
    • BIOMARKERS REFLECTING INFLAMMATION
    • SOLUBLE TRANSFERRIN RECEPTOR
    • NUTRITIONAL DETERMINANTS
    • CHILDREN
    • GROWTH
    • SUPPLEMENTATION
    • METABOLISM
    • FERRITIN

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