Iron status of Burkinabe adolescent girls predicts malaria risk in the following rainy season

Loretta Brabin; Stephen A. Roberts; Halidou Tinto; Sabine Gies; Salou Diallo; Bernard Brabin

doi:10.3390/nu12051446

Iron status of Burkinabe adolescent girls predicts malaria risk in the following rainy season

Loretta Brabin, Stephen A. Roberts, Halidou Tinto, Sabine Gies, Salou Diallo, Bernard Brabin

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Abstract

High levels of storage iron may increase malaria susceptibility. This risk has not been investigated in semi-immune adolescents. We investigated whether baseline iron status of non-pregnant adolescent girls living in a high malaria transmission area in Burkina Faso affected malaria risk during the following rainy season. For this prospective study, we analysed data from an interim safety survey, conducted six months into a randomised iron supplementation trial. We used logistic regression to model the risk of P. falciparum infection prevalence by microscopy, the pre-specified interim safety outcome, in relation to iron status, nutritional indicators and menarche assessed at recruitment. The interim survey was attended by 1223 (82%) of 1486 eligible participants, 1084 (89%) of whom were

Original language	English
Article number	1446
Journal	Nutrients
Volume	12
Issue number	5
Number of pages	15
ISSN	2072-6643
DOIs	https://doi.org/10.3390/nu12051446
Publication status	Published - 2020

Keywords

iron biomarkers
malaria
adolescent girls
menarche
body mass index
Burkina Faso
BIOMARKERS REFLECTING INFLAMMATION
SOLUBLE TRANSFERRIN RECEPTOR
NUTRITIONAL DETERMINANTS
CHILDREN
GROWTH
SUPPLEMENTATION
METABOLISM
FERRITIN

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10.3390/nu12051446Licence: CC BY

2020nutr0001Final published version, 2.28 MBLicence: CC BY

Cite this

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title = "Iron status of Burkinabe adolescent girls predicts malaria risk in the following rainy season",

abstract = "High levels of storage iron may increase malaria susceptibility. This risk has not been investigated in semi-immune adolescents. We investigated whether baseline iron status of non-pregnant adolescent girls living in a high malaria transmission area in Burkina Faso affected malaria risk during the following rainy season. For this prospective study, we analysed data from an interim safety survey, conducted six months into a randomised iron supplementation trial. We used logistic regression to model the risk of P. falciparum infection prevalence by microscopy, the pre-specified interim safety outcome, in relation to iron status, nutritional indicators and menarche assessed at recruitment. The interim survey was attended by 1223 (82%) of 1486 eligible participants, 1084 (89%) of whom were",

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doi = "10.3390/nu12051446",

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T1 - Iron status of Burkinabe adolescent girls predicts malaria risk in the following rainy season

AU - Brabin, Loretta

AU - Roberts, Stephen A.

AU - Tinto, Halidou

AU - Gies, Sabine

AU - Diallo, Salou

AU - Brabin, Bernard

N1 - FTX; DOAJ; GOAA; (CC BY 4.0)

PY - 2020

Y1 - 2020

N2 - High levels of storage iron may increase malaria susceptibility. This risk has not been investigated in semi-immune adolescents. We investigated whether baseline iron status of non-pregnant adolescent girls living in a high malaria transmission area in Burkina Faso affected malaria risk during the following rainy season. For this prospective study, we analysed data from an interim safety survey, conducted six months into a randomised iron supplementation trial. We used logistic regression to model the risk of P. falciparum infection prevalence by microscopy, the pre-specified interim safety outcome, in relation to iron status, nutritional indicators and menarche assessed at recruitment. The interim survey was attended by 1223 (82%) of 1486 eligible participants, 1084 (89%) of whom were

AB - High levels of storage iron may increase malaria susceptibility. This risk has not been investigated in semi-immune adolescents. We investigated whether baseline iron status of non-pregnant adolescent girls living in a high malaria transmission area in Burkina Faso affected malaria risk during the following rainy season. For this prospective study, we analysed data from an interim safety survey, conducted six months into a randomised iron supplementation trial. We used logistic regression to model the risk of P. falciparum infection prevalence by microscopy, the pre-specified interim safety outcome, in relation to iron status, nutritional indicators and menarche assessed at recruitment. The interim survey was attended by 1223 (82%) of 1486 eligible participants, 1084 (89%) of whom were

KW - iron biomarkers

KW - malaria

KW - adolescent girls

KW - menarche

KW - body mass index

KW - Burkina Faso

KW - BIOMARKERS REFLECTING INFLAMMATION

KW - SOLUBLE TRANSFERRIN RECEPTOR

KW - NUTRITIONAL DETERMINANTS

KW - CHILDREN

KW - GROWTH

KW - SUPPLEMENTATION

KW - METABOLISM

KW - FERRITIN

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DO - 10.3390/nu12051446

M3 - A1: Web of Science-article

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VL - 12

JO - Nutrients

JF - Nutrients

IS - 5

M1 - 1446

ER -

Iron status of Burkinabe adolescent girls predicts malaria risk in the following rainy season

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Keywords

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