Schistosoma mansoni infection is associated with increased monocytes and fewer natural killer T cells in the female genital tract

Justin R. Kingery; Andrea Chalem; Crispin Mukerebe; Peter S. Shigella; Donald Miyaye; Ruth G. Magawa; Maureen Ward; Samuel E. Kalluvya; Jason McCormick; Jane K. Maganga; Soledad Colombe; Christine Aristide; Paul L. A. M. Corstjens; Myung Hee Lee; John M. Changalucha; Jennifer A. Downs

doi:10.1093/ofid/ofac657

Schistosoma mansoni infection is associated with increased monocytes and fewer natural killer T cells in the female genital tract

Justin R. Kingery, Andrea Chalem, Crispin Mukerebe, Peter S. Shigella, Donald Miyaye, Ruth G. Magawa, Maureen Ward, Samuel E. Kalluvya, Jason McCormick, Jane K. Maganga, Soledad Colombe, Christine Aristide, Paul L. A. M. Corstjens, Myung Hee Lee, John M. Changalucha, Jennifer A. Downs

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Abstract

Schistosoma mansoni infection may impair genital mucosal antiviral immunity, but immune cell populations have not been well characterized. We characterized mononuclear cells from cervical brushings of women with and without S mansoni infection. We observed lower frequencies of natural killer T cells and higher frequencies of CD14(+) monocytes in infected women.

Original language	English
Article number	657
Journal	Open Forum Infectious Diseases
Volume	9
Issue number	12
Number of pages	5
ISSN	2328-8957
DOIs	https://doi.org/10.1093/ofid/ofac657
Publication status	Published - 2022

Keywords

female urogenital schistosomiasis
monocytes
Schistosoma mansoni
schistosomiasis
women
HELMINTH INFECTION
WOMEN
PATHOLOGY
RESPONSES
CERVIX

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2022ofidofac657Final published version, 478 KBLicence: CC BY-NC-ND

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Kingery, J. R., Chalem, A., Mukerebe, C., Shigella, P. S., Miyaye, D., Magawa, R. G., Ward, M., Kalluvya, S. E., McCormick, J., Maganga, J. K., Colombe, S., Aristide, C., Corstjens, P. L. A. M., Lee, M. H., Changalucha, J. M., & Downs, J. A. (2022). Schistosoma mansoni infection is associated with increased monocytes and fewer natural killer T cells in the female genital tract. Open Forum Infectious Diseases, 9(12), Article 657. https://doi.org/10.1093/ofid/ofac657

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title = "Schistosoma mansoni infection is associated with increased monocytes and fewer natural killer T cells in the female genital tract",

abstract = "Schistosoma mansoni infection may impair genital mucosal antiviral immunity, but immune cell populations have not been well characterized. We characterized mononuclear cells from cervical brushings of women with and without S mansoni infection. We observed lower frequencies of natural killer T cells and higher frequencies of CD14(+) monocytes in infected women.",

keywords = "female urogenital schistosomiasis, monocytes, Schistosoma mansoni, schistosomiasis, women, HELMINTH INFECTION, WOMEN, PATHOLOGY, RESPONSES, CERVIX",

author = "Kingery, {Justin R.} and Andrea Chalem and Crispin Mukerebe and Shigella, {Peter S.} and Donald Miyaye and Magawa, {Ruth G.} and Maureen Ward and Kalluvya, {Samuel E.} and Jason McCormick and Maganga, {Jane K.} and Soledad Colombe and Christine Aristide and Corstjens, {Paul L. A. M.} and Lee, {Myung Hee} and Changalucha, {John M.} and Downs, {Jennifer A.}",

note = "FTX; DOAJ; (CC BY-NC-ND 4.0)",

year = "2022",

doi = "10.1093/ofid/ofac657",

language = "English",

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journal = "Open Forum Infectious Diseases",

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Kingery, JR, Chalem, A, Mukerebe, C, Shigella, PS, Miyaye, D, Magawa, RG, Ward, M, Kalluvya, SE, McCormick, J, Maganga, JK, Colombe, S, Aristide, C, Corstjens, PLAM, Lee, MH, Changalucha, JM & Downs, JA 2022, 'Schistosoma mansoni infection is associated with increased monocytes and fewer natural killer T cells in the female genital tract', Open Forum Infectious Diseases, vol. 9, no. 12, 657. https://doi.org/10.1093/ofid/ofac657

TY - JOUR

T1 - Schistosoma mansoni infection is associated with increased monocytes and fewer natural killer T cells in the female genital tract

AU - Kingery, Justin R.

AU - Chalem, Andrea

AU - Mukerebe, Crispin

AU - Shigella, Peter S.

AU - Miyaye, Donald

AU - Magawa, Ruth G.

AU - Ward, Maureen

AU - Kalluvya, Samuel E.

AU - McCormick, Jason

AU - Maganga, Jane K.

AU - Colombe, Soledad

AU - Aristide, Christine

AU - Corstjens, Paul L. A. M.

AU - Lee, Myung Hee

AU - Changalucha, John M.

AU - Downs, Jennifer A.

N1 - FTX; DOAJ; (CC BY-NC-ND 4.0)

PY - 2022

Y1 - 2022

N2 - Schistosoma mansoni infection may impair genital mucosal antiviral immunity, but immune cell populations have not been well characterized. We characterized mononuclear cells from cervical brushings of women with and without S mansoni infection. We observed lower frequencies of natural killer T cells and higher frequencies of CD14(+) monocytes in infected women.

AB - Schistosoma mansoni infection may impair genital mucosal antiviral immunity, but immune cell populations have not been well characterized. We characterized mononuclear cells from cervical brushings of women with and without S mansoni infection. We observed lower frequencies of natural killer T cells and higher frequencies of CD14(+) monocytes in infected women.

KW - female urogenital schistosomiasis

KW - monocytes

KW - Schistosoma mansoni

KW - schistosomiasis

KW - women

KW - HELMINTH INFECTION

KW - WOMEN

KW - PATHOLOGY

KW - RESPONSES

KW - CERVIX

U2 - 10.1093/ofid/ofac657

DO - 10.1093/ofid/ofac657

M3 - A1: Web of Science-article

SN - 2328-8957

VL - 9

JO - Open Forum Infectious Diseases

JF - Open Forum Infectious Diseases

IS - 12

M1 - 657

ER -

Schistosoma mansoni infection is associated with increased monocytes and fewer natural killer T cells in the female genital tract

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