Schistosoma mansoni infection is associated with increased monocytes and fewer natural killer T cells in the female genital tract

Justin R. Kingery, Andrea Chalem, Crispin Mukerebe, Peter S. Shigella, Donald Miyaye, Ruth G. Magawa, Maureen Ward, Samuel E. Kalluvya, Jason McCormick, Jane K. Maganga, Soledad Colombe, Christine Aristide, Paul L. A. M. Corstjens, Myung Hee Lee, John M. Changalucha, Jennifer A. Downs

    Research output: Contribution to journalA1: Web of Science-articlepeer-review

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    Abstract

    Schistosoma mansoni infection may impair genital mucosal antiviral immunity, but immune cell populations have not been well characterized. We characterized mononuclear cells from cervical brushings of women with and without S mansoni infection. We observed lower frequencies of natural killer T cells and higher frequencies of CD14(+) monocytes in infected women.

    Original languageEnglish
    Article number657
    JournalOpen Forum Infectious Diseases
    Volume9
    Issue number12
    Number of pages5
    ISSN2328-8957
    DOIs
    Publication statusPublished - 2022

    Keywords

    • female urogenital schistosomiasis
    • monocytes
    • Schistosoma mansoni
    • schistosomiasis
    • women
    • HELMINTH INFECTION
    • WOMEN
    • PATHOLOGY
    • RESPONSES
    • CERVIX

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