Karyotype polymorphism and conserved characters in the Leishmania (viannia) braziliensis complex explored with chromosome-derived probes

JC Dujardin; N Gajendran; J Arevalo; A Llanos-Cuentas; H Guerra; J Gomez; J Arroyo; S De Doncker; D Jacquet; R Hamers; D Le Ray

Karyotype polymorphism and conserved characters in the Leishmania (viannia) braziliensis complex explored with chromosome-derived probes

JC Dujardin, N Gajendran, J Arevalo, A Llanos-Cuentas, H Guerra, J Gomez, J Arroyo, S De Doncker, D Jacquet, R Hamers, D Le Ray

Research output: Contribution to journal › A1: Web of Science-article › peer-review

Abstract

Molecular karyotype of 45 reference populations of Neotropical leishmanias was analyzed with ethidium bromide staining and with 6 chromosome-derived probes selected from a genomic library of Leishmania (Viannia) braziliensis. Size-conserved patterns were identified and found to be specific to subgenus Viannia and to its constitutive species. An important issue for epidemiology and clinical investigations was the discrimination between L. (V.) peruviana and L. (V.) braziliensis, 2 species found very similar by other genetic techniques, but responsible for totally different clinical patterns. The suggested existence of genetically distinct demes, or karyodemes, within the group-species might also show to be of importance, as these populations might differ in virulence, host-specificity and clinical manifestations

Original language	English
Journal	Annales de la Société Belge de Médecine Tropicale
Volume	73
Pages (from-to)	101-118
ISSN	0365-6527
Publication status	Published - 1993

Keywords

B780-tropical-medicine
Protozoology
Leishmania
Karyotypes
DNA probes
Polymorphism
Laboratory
Molecular biology
America-Latin

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Dujardin, JC., Gajendran, N., Arevalo, J., Llanos-Cuentas, A., Guerra, H., Gomez, J., Arroyo, J., De Doncker, S., Jacquet, D., Hamers, R., & Le Ray, D. (1993). Karyotype polymorphism and conserved characters in the Leishmania (viannia) braziliensis complex explored with chromosome-derived probes. Annales de la Société Belge de Médecine Tropicale, 73, 101-118. http://lib.itg.be/open/asbmt/1993/1993asbm0101.pdf

@article{9662483b10dd45869245cb462b89e909,

title = "Karyotype polymorphism and conserved characters in the Leishmania (viannia) braziliensis complex explored with chromosome-derived probes",

abstract = "Molecular karyotype of 45 reference populations of Neotropical leishmanias was analyzed with ethidium bromide staining and with 6 chromosome-derived probes selected from a genomic library of Leishmania (Viannia) braziliensis. Size-conserved patterns were identified and found to be specific to subgenus Viannia and to its constitutive species. An important issue for epidemiology and clinical investigations was the discrimination between L. (V.) peruviana and L. (V.) braziliensis, 2 species found very similar by other genetic techniques, but responsible for totally different clinical patterns. The suggested existence of genetically distinct demes, or karyodemes, within the group-species might also show to be of importance, as these populations might differ in virulence, host-specificity and clinical manifestations",

keywords = "B780-tropical-medicine, Protozoology, Leishmania, Karyotypes, DNA probes, Polymorphism, Laboratory, Molecular biology, America-Latin",

author = "JC Dujardin and N Gajendran and J Arevalo and A Llanos-Cuentas and H Guerra and J Gomez and J Arroyo and {De Doncker}, S and D Jacquet and R Hamers and {Le Ray}, D",

year = "1993",

language = "English",

volume = "73",

pages = "101--118",

journal = "Annales de la Soci{\'e}t{\'e} Belge de M{\'e}decine Tropicale",

issn = "0365-6527",

publisher = "Acco",

}

Dujardin, JC, Gajendran, N, Arevalo, J, Llanos-Cuentas, A, Guerra, H, Gomez, J, Arroyo, J, De Doncker, S, Jacquet, D, Hamers, R & Le Ray, D 1993, 'Karyotype polymorphism and conserved characters in the Leishmania (viannia) braziliensis complex explored with chromosome-derived probes', Annales de la Société Belge de Médecine Tropicale, vol. 73, pp. 101-118. <http://lib.itg.be/open/asbmt/1993/1993asbm0101.pdf>

TY - JOUR

T1 - Karyotype polymorphism and conserved characters in the Leishmania (viannia) braziliensis complex explored with chromosome-derived probes

AU - Dujardin, JC

AU - Gajendran, N

AU - Arevalo, J

AU - Llanos-Cuentas, A

AU - Guerra, H

AU - Gomez, J

AU - Arroyo, J

AU - De Doncker, S

AU - Jacquet, D

AU - Hamers, R

AU - Le Ray, D

PY - 1993

Y1 - 1993

N2 - Molecular karyotype of 45 reference populations of Neotropical leishmanias was analyzed with ethidium bromide staining and with 6 chromosome-derived probes selected from a genomic library of Leishmania (Viannia) braziliensis. Size-conserved patterns were identified and found to be specific to subgenus Viannia and to its constitutive species. An important issue for epidemiology and clinical investigations was the discrimination between L. (V.) peruviana and L. (V.) braziliensis, 2 species found very similar by other genetic techniques, but responsible for totally different clinical patterns. The suggested existence of genetically distinct demes, or karyodemes, within the group-species might also show to be of importance, as these populations might differ in virulence, host-specificity and clinical manifestations

AB - Molecular karyotype of 45 reference populations of Neotropical leishmanias was analyzed with ethidium bromide staining and with 6 chromosome-derived probes selected from a genomic library of Leishmania (Viannia) braziliensis. Size-conserved patterns were identified and found to be specific to subgenus Viannia and to its constitutive species. An important issue for epidemiology and clinical investigations was the discrimination between L. (V.) peruviana and L. (V.) braziliensis, 2 species found very similar by other genetic techniques, but responsible for totally different clinical patterns. The suggested existence of genetically distinct demes, or karyodemes, within the group-species might also show to be of importance, as these populations might differ in virulence, host-specificity and clinical manifestations

KW - B780-tropical-medicine

KW - Protozoology

KW - Leishmania

KW - Karyotypes

KW - DNA probes

KW - Polymorphism

KW - Laboratory

KW - Molecular biology

KW - America-Latin

M3 - A1: Web of Science-article

SN - 0365-6527

VL - 73

SP - 101

EP - 118

JO - Annales de la Société Belge de Médecine Tropicale

JF - Annales de la Société Belge de Médecine Tropicale

ER -

Karyotype polymorphism and conserved characters in the Leishmania (viannia) braziliensis complex explored with chromosome-derived probes

Abstract

Keywords

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