Karyotype polymorphism and conserved characters in the Leishmania (viannia) braziliensis complex explored with chromosome-derived probes

JC Dujardin, N Gajendran, J Arevalo, A Llanos-Cuentas, H Guerra, J Gomez, J Arroyo, S De Doncker, D Jacquet, R Hamers, D Le Ray

Research output: Contribution to journalA1: Web of Science-article


Molecular karyotype of 45 reference populations of Neotropical leishmanias was analyzed with ethidium bromide staining and with 6 chromosome-derived probes selected from a genomic library of Leishmania (Viannia) braziliensis. Size-conserved patterns were identified and found to be specific to subgenus Viannia and to its constitutive species. An important issue for epidemiology and clinical investigations was the discrimination between L. (V.) peruviana and L. (V.) braziliensis, 2 species found very similar by other genetic techniques, but responsible for totally different clinical patterns. The suggested existence of genetically distinct demes, or karyodemes, within the group-species might also show to be of importance, as these populations might differ in virulence, host-specificity and clinical manifestations
Original languageEnglish
JournalAnnales de la Société Belge de Médecine Tropicale
Pages (from-to)101-118
Publication statusPublished - 1993


  • B780-tropical-medicine
  • Protozoology
  • Leishmania
  • Karyotypes
  • DNA probes
  • Polymorphism
  • Laboratory
  • Molecular biology
  • America-Latin


Dive into the research topics of 'Karyotype polymorphism and conserved characters in the <i>Leishmania (viannia) braziliensis</i> complex explored with chromosome-derived probes'. Together they form a unique fingerprint.

Cite this