Kinetics of the appearance of cereal alkylresorcinols in pig plasma

AM Linko, AB Ross, A Kamal-Eldin, A Serena, AKB Kjaer, H Jorgensen, JL Penalvo, H Adlercreutz, P Aman, KEB Knudsen

Research output: Contribution to journalArticlepeer-review

Abstract

Alkylresorcinols (AR) are phenolic lipids found in high amounts in wholegrain wheat and rye. They may be important as bioactive components and/or biomarkers of wholegrain wheat and rye intake. AR absorption was studied with pigs during a habitual diet and after a single meal of AR-rich diet. In study 1, four pigs were fed wholegrain rye (RD) and white wheat bread (WD) for 1 week in a cross-over design. Arterial and venous AR concentrations were determined over 540 min after feeding on days 5 and 7. In study 2, four pigs were fed a synthetic, starch-based diet for 5 d, and arterial and venous AR concentrations were determined over 960 min after feeding a single meal of RD. In study 1, plasma AR concentrations after consuming RD peaked at 120 min, remained elevated between 120 and 420 min, and were re-elevated on refeeding at 480 min. In study 2, AR appeared in the plasma after 60 min, peaked at 180-240 min, and remained elevated after 960 min. The apparent elimination half-life was 3.93 h, and the maximum plasma concentration was 666 (sem 35) nmol/l. Arterial and venous plasma AR concentrations were similar, suggesting that AR are absorbed via the lymphatic system. AR concentrations in pig plasma increase rapidly after a meal containing AR, and persist in plasma for at least 5 d, indicating that AR may be a useful biomarker of wholegrain wheat and rye intake.

Original languageEnglish
JournalBritish Journal of Nutrition
Volume95
Issue number2
Pages (from-to)282-287
Number of pages6
ISSN0007-1145
DOIs
Publication statusPublished - Feb-2006

Keywords

  • alkylresorcinols
  • biomarkers
  • wholegrain cereals
  • rye
  • WHOLE-GRAIN WHEAT
  • DIETARY ALKYLRESORCINOLS
  • CHROMATOGRAPHIC ANALYSIS
  • RYE BREAD
  • ABSORPTION
  • BIOMARKERS
  • TOCOPHEROL
  • INCREASES
  • DISEASE
  • URINE

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