Lactating mothers infected with Ebola virus: EBOV RT-PCR of blood only may be insufficient

M Moreau; C Spencer; J G Gozalbes; R Colebunders; A Lefevre; S Gryseels; B Borremans; S Gunther; D Becker; J A Bore; F R Koundouno; A Di Caro; R Wölfel; T Decroo; M Van Herp; L Peetermans; A M Camara

doi:10.2807/1560-7917.es2015.20.3.21017

Lactating mothers infected with Ebola virus: EBOV RT-PCR of blood only may be insufficient

M Moreau
, C Spencer
, J G Gozalbes
, R Colebunders
, A Lefevre
, S Gryseels
, B Borremans
, S Gunther
, D Becker
, J A Bore
, F R Koundouno
, A Di Caro
, R Wölfel
, T Decroo
, M Van Herp
, L Peetermans
, A M Camara

Tuberculosis

Research output: Contribution to journal › A1: Peer-reviewed journal articles › peer-review

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Abstract

We describe two Ebola virus (EBOV) RT-PCR discordant mother–child pairs. In the first, blood from the breastfeeding mother, recovering from EBOV infection, tested negative twice but her urine tested positive. Her child became infected by EBOV and died. In the second, the breastfed child remained EBOV-negative, although the mother’s blood tested positive. We highlight possible benefits of EBOV RT-PCR testing in urine and breast milk and the need for hygiene counselling when those fluids are EBOV-positive.

Original language	English
Article number	pii=21017
Journal	Eurosurveillance
Volume	20
Issue number	3
ISSN	1560-7917
DOIs	https://doi.org/10.2807/1560-7917.es2015.20.3.21017
Publication status	Published - 22-Jan-2015

Keywords

Adult
Body Fluids/virology
Ebolavirus/genetics
Female
Hemorrhagic Fever, Ebola/blood
Humans
Infant
Lactation
Milk, Human/virology
Mothers
RNA, Viral/analysis
Reverse Transcriptase Polymerase Chain Reaction/methods

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Moreau, M., Spencer, C., Gozalbes, J. G., Colebunders, R., Lefevre, A., Gryseels, S., Borremans, B., Gunther, S., Becker, D., Bore, J. A., Koundouno, F. R., Di Caro, A., Wölfel, R., Decroo, T., Van Herp, M., Peetermans, L., & Camara, A. M. (2015). Lactating mothers infected with Ebola virus: EBOV RT-PCR of blood only may be insufficient. Eurosurveillance, 20(3), Article pii=21017. https://doi.org/10.2807/1560-7917.es2015.20.3.21017

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title = "Lactating mothers infected with Ebola virus: EBOV RT-PCR of blood only may be insufficient",

abstract = "We describe two Ebola virus (EBOV) RT-PCR discordant mother–child pairs. In the first, blood from the breastfeeding mother, recovering from EBOV infection, tested negative twice but her urine tested positive. Her child became infected by EBOV and died. In the second, the breastfed child remained EBOV-negative, although the mother{\textquoteright}s blood tested positive. We highlight possible benefits of EBOV RT-PCR testing in urine and breast milk and the need for hygiene counselling when those fluids are EBOV-positive.",

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Moreau, M, Spencer, C, Gozalbes, JG, Colebunders, R, Lefevre, A, Gryseels, S, Borremans, B, Gunther, S, Becker, D, Bore, JA, Koundouno, FR, Di Caro, A, Wölfel, R, Decroo, T, Van Herp, M, Peetermans, L & Camara, AM 2015, 'Lactating mothers infected with Ebola virus: EBOV RT-PCR of blood only may be insufficient', Eurosurveillance, vol. 20, no. 3, pii=21017. https://doi.org/10.2807/1560-7917.es2015.20.3.21017

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T1 - Lactating mothers infected with Ebola virus: EBOV RT-PCR of blood only may be insufficient

AU - Moreau, M

AU - Spencer, C

AU - Gozalbes, J G

AU - Colebunders, R

AU - Lefevre, A

AU - Gryseels, S

AU - Borremans, B

AU - Gunther, S

AU - Becker, D

AU - Bore, J A

AU - Koundouno, F R

AU - Di Caro, A

AU - Wölfel, R

AU - Decroo, T

AU - Van Herp, M

AU - Peetermans, L

AU - Camara, A M

N1 - FTX: OA

PY - 2015/1/22

Y1 - 2015/1/22

N2 - We describe two Ebola virus (EBOV) RT-PCR discordant mother–child pairs. In the first, blood from the breastfeeding mother, recovering from EBOV infection, tested negative twice but her urine tested positive. Her child became infected by EBOV and died. In the second, the breastfed child remained EBOV-negative, although the mother’s blood tested positive. We highlight possible benefits of EBOV RT-PCR testing in urine and breast milk and the need for hygiene counselling when those fluids are EBOV-positive.

AB - We describe two Ebola virus (EBOV) RT-PCR discordant mother–child pairs. In the first, blood from the breastfeeding mother, recovering from EBOV infection, tested negative twice but her urine tested positive. Her child became infected by EBOV and died. In the second, the breastfed child remained EBOV-negative, although the mother’s blood tested positive. We highlight possible benefits of EBOV RT-PCR testing in urine and breast milk and the need for hygiene counselling when those fluids are EBOV-positive.

KW - Adult

KW - Body Fluids/virology

KW - Ebolavirus/genetics

KW - Female

KW - Hemorrhagic Fever, Ebola/blood

KW - Humans

KW - Infant

KW - Lactation

KW - Milk, Human/virology

KW - Mothers

KW - RNA, Viral/analysis

KW - Reverse Transcriptase Polymerase Chain Reaction/methods

UR - https://www.webofscience.com/wos/woscc/full-record/WOS:000348287400003

U2 - 10.2807/1560-7917.es2015.20.3.21017

DO - 10.2807/1560-7917.es2015.20.3.21017

M3 - A1: Peer-reviewed journal articles

C2 - 25635320

SN - 1560-7917

VL - 20

JO - Eurosurveillance

JF - Eurosurveillance

IS - 3

M1 - pii=21017

ER -

Lactating mothers infected with Ebola virus: EBOV RT-PCR of blood only may be insufficient

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