Leishmaniasis

Sakib Burza, Simon L Croft, Marleen Boelaert

    Research output: Contribution to journalA1: Web of Science-article

    Abstract

    Leishmaniasis is a poverty-related disease with two main clinical forms: visceral leishmaniasis and cutaneous leishmaniasis. An estimated 0·7-1 million new cases of leishmaniasis per year are reported from nearly 100 endemic countries. The number of reported visceral leishmaniasis cases has decreased substantially in the past decade as a result of better access to diagnosis and treatment and more intense vector control within an elimination initiative in Asia, although natural cycles in transmission intensity might play a role. In east Africa however, the case numbers of this fatal disease continue to be sustained. Increased conflict in endemic areas of cutaneous leishmaniasis and forced displacement has resulted in a surge in these endemic areas as well as clinics across the world. WHO lists leishmaniasis as one of the neglected tropical diseases for which the development of new treatments is a priority. Major evidence gaps remain, and new tools are needed before leishmaniasis can be definitively controlled.

    Original languageEnglish
    JournalLancet
    Volume392
    Issue number10151
    Pages (from-to)951-970
    Number of pages20
    ISSN0140-6736
    DOIs
    Publication statusPublished - 2018

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