Local application of diminazene aceturate: an effective treatment for cutaneous leishmaniasis?

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Abstract

In a controlled clinical trial we tested the effect of diminazene aceturate (Berenyl, Bayer) in local application against cutaneous leishmaniasis. The study was performed among schoolchildren in Nyala, West-Sudan in 1988 during a major outbreak of cutaneous leishmaniasis in this region. Sixty-six schoolchildren with cutaneous leishmaniasis were enrolled in the study. The children were randomly assigned to either diminazene aceturate (Berenil) or cetrimide 15% + chlorhexidine 1.5% (Savlon) treatment. The study results show a significant faster healing of the ulcers in the children treated with diminazene aceturate (chi-square 7.31, p less than 0.01). We conclude that diminazene aceturate should be considered as a potential topical drug in the treatment of cutaneous leishmaniasis
Original languageEnglish
JournalAnnales de la Société Belge de Médecine Tropicale
Volume72
Pages (from-to)13-19
ISSN0365-6527
Publication statusPublished - 1992

Keywords

  • B780-tropical-medicine
  • Protozoal diseases
  • Leishmaniasis
  • Antiprotozoal agents
  • Diminazene
  • Berenil
  • Sudan
  • Africa-East

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