Long-lasting insecticidal nets provide protection against malaria for only a single year in Burundi, an African highland setting with marked malaria seasonality

Wim Van Bortel, Joachim Mariën, Bart K M Jacobs, Denis Sinzinkayo, Pierre Sinarinzi, Emmanuel Lampaert, Rob D'hondt, Jean-Marie Mafuko, Anja De Weggheleire, Florian Vogt, Neil Alexander, William Wint, Peter Maes, Veerle Vanlerberghe, Corey Leclair

Research output: Contribution to journalA1: Web of Science-articlepeer-review

Abstract

BACKGROUND: Long-lasting insecticidal nets (LLINs) are one of the key interventions in the global fight against malaria. Since 2014, mass distribution campaigns of LLINs aim for universal access by all citizens of Burundi. In this context, we assess the impact of LLINs mass distribution campaigns on malaria incidence, focusing on the endemic highland health districts. We also explored the possible correlation between observed trends in malaria incidence with any variations in climate conditions.

METHODS: Malaria cases for 2011-2019 were obtained from the National Health Information System. We developed a generalised additive model based on a time series of routinely collected data with malaria incidence as the response variable and timing of LLIN distribution as an explanatory variable to investigate the duration and magnitude of the LLIN effect on malaria incidence. We added a seasonal and continuous-time component as further explanatory variables, and health district as a random effect to account for random natural variation in malaria cases between districts.

RESULTS: Malaria transmission in Burundian highlands was clearly seasonal and increased non-linearly over the study period. Further, a fast and steep decline of malaria incidence was noted during the first year after mass LLIN distribution (p<0.0001). In years 2 and 3 after distribution, malaria cases started to rise again to levels higher than before the control intervention.

CONCLUSION: This study highlights that LLINs did reduce the incidence in the first year after a mass distribution campaign, but in the context of Burundi, LLINs lost their impact after only 1 year.

Original languageEnglish
Article numbere009674
JournalBMJ Global Health
Volume7
Issue number12
Number of pages9
ISSN2059-7908
DOIs
Publication statusPublished - 2022

Keywords

  • Humans
  • Insecticides
  • Burundi/epidemiology
  • Malaria/epidemiology
  • Health Information Systems
  • Time Factors

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