Low CD4+ T cell counts among African HIV-1 infected subjects with group B KIR haplotypes in the absence of specific inhibitory KIR ligands

W Jennes, S Verheyden, C Demanet, J Menten, B Vuylsteke, JN Nkengasong, L Kestens

    Research output: Contribution to journalA1: Web of Science-article

    Abstract

    Natural killer (NK) cells are regulated by interactions between polymorphic killer immunoglobulin-like receptors (KIR) and human leukocyte antigens (HLA). Genotypic combinations of KIR3DS1/L1 and HLA Bw4-80I were previously shown to influence HIV-1 disease progression, however other KIR genes have not been well studied. In this study, we analyzed the influence of all activating and inhibitory KIR, in association with the known HLA inhibitory KIR ligands, on markers of disease progression in a West African population of therapy-naive HIV-1 infected subjects. We observed a significant association between carriage of a group B KIR haplotype and lower CD4+ T cell counts, with an additional effect for KIR3DS1 within the frame of this haplotype. In contrast, we found that individuals carrying genes for the inhibitory KIR ligands HLA-Bw4 as well as HLA-C1 showed significantly higher CD4+ T cell counts. These associations were independent from the viral load and from individual HIV-1 protective HLA alleles. Our data suggest that group B KIR haplotypes and lack of specific inhibitory KIR ligand genes, genotypes considered to favor NK cell activation, are predictive of HIV-1 disease progression.
    Original languageEnglish
    JournalPLoS ONE
    Volume6
    Issue number2
    Pages (from-to)e17043
    Number of pages7
    ISSN1932-6203
    DOIs
    Publication statusPublished - 2011

    Keywords

    • B780-tropical-medicine
    • Viral diseases
    • HIV-1
    • AIDS
    • Immune response
    • Natural killer cells
    • Immunoglobulins
    • Receptors
    • Leukocytes
    • Antigens
    • Disease progression
    • HLA ligands
    • Markers
    • CD4-positive-T-lymphocytes
    • Haplotypes
    • HLA-Bw4
    • HLA-C1
    • Associations

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