Low cycle threshold value in Xpert MTB/RIF assay may herald false detection of tuberculosis and rifampicin resistance: a study of two cases

Jean Claude S. Ngabonziza, Tom Decroo, Rodrigue Maniliho, Yves M. Habimana, Armand Van Deun, Bouke C. de Jong

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We report 2 cases for whom Xpert MTB/RIF falsely signaled rifampicin-resistant tuberculosis, based on unusually low cycle threshold and 3 of 5 probes missing. Other mycobacterial tests were negative. Further optimization of the Xpert MTB/RIF algorithm is warranted.

Original languageEnglish
Article number034
JournalOpen Forum Infectious Diseases
Issue number2
Number of pages5
Publication statusPublished - 2021


  • active case finding
  • false detection of TB
  • rifampicin resistance
  • Xpert MTB/RIF assay

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