Low cycle threshold value in Xpert MTB/RIF assay may herald false detection of tuberculosis and rifampicin resistance: a study of two cases

Jean Claude S. Ngabonziza; Tom Decroo; Rodrigue Maniliho; Yves M. Habimana; Armand Van Deun; Bouke C. de Jong

doi:10.1093/ofid/ofab034

Low cycle threshold value in Xpert MTB/RIF assay may herald false detection of tuberculosis and rifampicin resistance: a study of two cases

Jean Claude S. Ngabonziza
, Tom Decroo
, Rodrigue Maniliho
, Yves M. Habimana
, Armand Van Deun
, Bouke C. de Jong

Research output: Contribution to journal › A1: Peer-reviewed journal articles › peer-review

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Abstract

We report 2 cases for whom Xpert MTB/RIF falsely signaled rifampicin-resistant tuberculosis, based on unusually low cycle threshold and 3 of 5 probes missing. Other mycobacterial tests were negative. Further optimization of the Xpert MTB/RIF algorithm is warranted.

Original language	English
Article number	ofab034
Journal	Open Forum Infectious Diseases
Volume	8
Issue number	2
Number of pages	5
ISSN	2328-8957
DOIs	https://doi.org/10.1093/ofid/ofab034
Publication status	Published - 2021

Keywords

active case finding
false detection of TB
rifampicin resistance
Xpert MTB/RIF assay

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10.1093/ofid/ofab034Licence: CC BY-NC-ND

2021ofidofab034Final published version, 703 KBLicence: CC BY-NC-ND

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title = "Low cycle threshold value in Xpert MTB/RIF assay may herald false detection of tuberculosis and rifampicin resistance: a study of two cases",

abstract = "We report 2 cases for whom Xpert MTB/RIF falsely signaled rifampicin-resistant tuberculosis, based on unusually low cycle threshold and 3 of 5 probes missing. Other mycobacterial tests were negative. Further optimization of the Xpert MTB/RIF algorithm is warranted.",

keywords = "active case finding, false detection of TB, rifampicin resistance, Xpert MTB/RIF assay",

author = "Ngabonziza, \{Jean Claude S.\} and Tom Decroo and Rodrigue Maniliho and Habimana, \{Yves M.\} and \{Van Deun\}, Armand and \{de Jong\}, \{Bouke C.\}",

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Low cycle threshold value in Xpert MTB/RIF assay may herald false detection of tuberculosis and rifampicin resistance: a study of two cases. / Ngabonziza, Jean Claude S.; Decroo, Tom; Maniliho, Rodrigue et al.
In: Open Forum Infectious Diseases, Vol. 8, No. 2, ofab034, 2021.

Research output: Contribution to journal › A1: Peer-reviewed journal articles › peer-review

TY - JOUR

T1 - Low cycle threshold value in Xpert MTB/RIF assay may herald false detection of tuberculosis and rifampicin resistance: a study of two cases

AU - Ngabonziza, Jean Claude S.

AU - Decroo, Tom

AU - Maniliho, Rodrigue

AU - Habimana, Yves M.

AU - Van Deun, Armand

AU - de Jong, Bouke C.

N1 - FTX; DOAJ; (CC BY-NC-ND 4.0)

PY - 2021

Y1 - 2021

N2 - We report 2 cases for whom Xpert MTB/RIF falsely signaled rifampicin-resistant tuberculosis, based on unusually low cycle threshold and 3 of 5 probes missing. Other mycobacterial tests were negative. Further optimization of the Xpert MTB/RIF algorithm is warranted.

AB - We report 2 cases for whom Xpert MTB/RIF falsely signaled rifampicin-resistant tuberculosis, based on unusually low cycle threshold and 3 of 5 probes missing. Other mycobacterial tests were negative. Further optimization of the Xpert MTB/RIF algorithm is warranted.

KW - active case finding

KW - false detection of TB

KW - rifampicin resistance

KW - Xpert MTB/RIF assay

UR - https://www.webofscience.com/wos/woscc/full-record/WOS:000637323400071

U2 - 10.1093/ofid/ofab034

DO - 10.1093/ofid/ofab034

M3 - A1: Peer-reviewed journal articles

C2 - 33614819

SN - 2328-8957

VL - 8

JO - Open Forum Infectious Diseases

JF - Open Forum Infectious Diseases

IS - 2

M1 - ofab034

ER -

Low cycle threshold value in Xpert MTB/RIF assay may herald false detection of tuberculosis and rifampicin resistance: a study of two cases

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