Low cycle threshold value in Xpert MTB/RIF assay may herald false detection of tuberculosis and rifampicin resistance: a study of two cases

Jean Claude S. Ngabonziza; Tom Decroo; Rodrigue Maniliho; Yves M. Habimana; Armand Van Deun; Bouke C. de Jong

doi:10.1093/ofid/ofab034

Low cycle threshold value in Xpert MTB/RIF assay may herald false detection of tuberculosis and rifampicin resistance: a study of two cases

Jean Claude S. Ngabonziza, Tom Decroo, Rodrigue Maniliho, Yves M. Habimana, Armand Van Deun, Bouke C. de Jong

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Abstract

We report 2 cases for whom Xpert MTB/RIF falsely signaled rifampicin-resistant tuberculosis, based on unusually low cycle threshold and 3 of 5 probes missing. Other mycobacterial tests were negative. Further optimization of the Xpert MTB/RIF algorithm is warranted.

Original language	English
Article number	034
Journal	Open Forum Infectious Diseases
Volume	8
Issue number	2
Number of pages	5
ISSN	2328-8957
DOIs	https://doi.org/10.1093/ofid/ofab034
Publication status	Published - 2021

Keywords

active case finding
false detection of TB
rifampicin resistance
Xpert MTB/RIF assay

Access to Document

10.1093/ofid/ofab034Licence: CC BY-NC-ND

2021ofidofab034Final published version, 703 KBLicence: CC BY-NC-ND

Cite this

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title = "Low cycle threshold value in Xpert MTB/RIF assay may herald false detection of tuberculosis and rifampicin resistance: a study of two cases",

abstract = "We report 2 cases for whom Xpert MTB/RIF falsely signaled rifampicin-resistant tuberculosis, based on unusually low cycle threshold and 3 of 5 probes missing. Other mycobacterial tests were negative. Further optimization of the Xpert MTB/RIF algorithm is warranted.",

keywords = "active case finding, false detection of TB, rifampicin resistance, Xpert MTB/RIF assay",

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AU - Ngabonziza, Jean Claude S.

AU - Decroo, Tom

AU - Maniliho, Rodrigue

AU - Habimana, Yves M.

AU - Van Deun, Armand

AU - de Jong, Bouke C.

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AB - We report 2 cases for whom Xpert MTB/RIF falsely signaled rifampicin-resistant tuberculosis, based on unusually low cycle threshold and 3 of 5 probes missing. Other mycobacterial tests were negative. Further optimization of the Xpert MTB/RIF algorithm is warranted.

KW - active case finding

KW - false detection of TB

KW - rifampicin resistance

KW - Xpert MTB/RIF assay

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DO - 10.1093/ofid/ofab034

M3 - A1: Web of Science-article

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