Low frequency of liver enzyme elevation in HIV-infected patients attending a large urban treatment centre in Uganda

P Ocama, B Castelnuovo, MR Kamya, GD Kirk, SJ Reynolds, A Kiragga, R Colebunders, DL Thomas

    Research output: Contribution to journalA1: Web of Science-article

    Abstract

    Liver enzyme elevations among patients on antiretroviral therapy (ART) were determined by prospectively evaluating aspartate aminotransferase (AST) data in a cohort of patients in Kampala over 36 months. A proportion of patients had hepatitis B virus (HBV) status determined. Hepatotoxicity was graded I to IV according to the AIDS Clinical Trial Group criteria. Of 546 patients, 377 (69%) were women; overall median baseline CD4+ T-cell was 97/muL (interquartile range [IQR] 20-164). Hepatitis B surface antigen (HBsAg) was detected in 42 (9%) of 470 persons. ART included lamivudine, with either nevirapine and d4T (74%) or efavirenz and AZT (26%). Median (IQR) AST level at baseline was 35 (27, 53 IU/L). Over 36 months, only eight patients had grade III AST elevation. Neither HBsAg nor ART regimen influenced AST levels. Male gender and CD4+ change from baseline were correlated with AST elevation. Patients with HIV/HBV co-infection were not at an increased risk of AST elevation, which occurred uncommonly in this setting
    Original languageEnglish
    JournalInternational Journal of STD & AIDS
    Volume21
    Issue number8
    Pages (from-to)553-557
    Number of pages5
    ISSN0956-4624
    DOIs
    Publication statusPublished - 2010

    Keywords

    • B780-tropical-medicine
    • Viral diseases
    • HIV
    • AIDS
    • HAART
    • Antiretrovirals
    • Liver
    • Enzymes
    • Toxicity
    • Liver stage
    • Hepatitis B
    • Antigens
    • Lamivudine
    • Nevirapine
    • Efavirenz
    • AZT
    • Gender
    • CD4+
    • Uganda
    • Africa-East

    Fingerprint

    Dive into the research topics of 'Low frequency of liver enzyme elevation in HIV-infected patients attending a large urban treatment centre in Uganda'. Together they form a unique fingerprint.

    Cite this