M48U1 CD4 mimetic has a sustained inhibitory effect on cell-associated HIV-1 by attenuating virion infectivity through gp120 shedding

P. Selhorst, K. Grupping, T. Tong, E.T. Crooks, L. Martin, G. Vanham, J.M. Binley, K.K. Ariën

Research output: Contribution to journalA1: Web of Science-article

10 Downloads (Pure)

Abstract

BACKGROUND: HIV-1 infected cells can establish new infections by crossing the vaginal epithelia and subsequently producing virus in a milieu that avoids the high microbicide concentrations of the vaginal lumen. FINDINGS: To address this problem, here, we report that pretreatment of HIV-infected peripheral blood mononuclear cells (PBMCs) with a 27 amino acid CD4-mimetic, M48U1, causes dramatic and prolonged reduction of infectious virus output, due to its induction of gp120 shedding. CONCLUSIONS: M48U1 may, therefore, be valuable for prophylaxis of mucosal HIV-1 transmission.
Original languageEnglish
JournalRetrovirology
Volume10
Issue number12
Pages (from-to)1-9
Number of pages9
ISSN1742-4690
DOIs
Publication statusPublished - 2013

Keywords

  • Viral diseases
  • HIV-1
  • AIDS
  • Infectivity
  • Epithelial cells
  • Vagina
  • Peripheral blood mononuclear cell (PBMC)
  • Amino acids
  • CD4
  • GP120
  • Prophylaxis
  • Inhibition
  • Development

Fingerprint Dive into the research topics of 'M48U1 CD4 mimetic has a sustained inhibitory effect on cell-associated HIV-1 by attenuating virion infectivity through gp120 shedding'. Together they form a unique fingerprint.

Cite this