Malaria early in the first pregnancy: potential impact of iron status

Salou Diallo, Stephen A. Roberts, Sabine Gies, Toussaint Rouamba, Dorine W. Swinkels, Anneke J. Geurts-Moespot, Sayouba Ouedraogo, Georges Anicet Ouedraogo, Halidou Tinto, Bernard J. Brabin

    Research output: Contribution to journalA1: Web of Science-article

    Abstract

    Background & aims: Low iron stores may protect from malaria infection, therefore improving iron stores in early pregnancy in line with current recommendations could increase malaria susceptibility. To test this hypothesis we compared iron biomarkers and red cell indices in nulliparae and primigravidae who participated in a randomized controlled trial of long-term weekly iron supplementation.

    Methods: Cross-sectional and longitudinal data analysis from a randomized controlled trial of long-term weekly iron supplementation in rural Burkina Faso. Malaria parasitaemia was monitored and biomarkers and red cell indices measured at study end-points: plasma ferritin, transferrin receptor (sTfR), zinc protoporphyrin, hepcidin, sTfR/log(10) ferritin ratio, body iron, haemoglobin, red cell distribution width; mean corpuscular haemoglobin concentration/volume, and C-reactive protein. Correlation coefficients between biomarkers and red cell indices were determined. A regression correction approach based on ferritin was used to estimate iron body stores, allowing for inflammation. Body iron differences were compared between nulliparae and primigravidae, and the association determined of iron biomarkers and body iron stores with malaria.

    Results: Iron and haematological indices of 972 nulliparae (mean age 16.5 years) and 314 primigravidae (median gestation 18 weeks) were available. Malaria prevalence was 54.0% in primigravidae and 41.8% in nulliparae (relative risk 1.28, 95% CI 1.13-1.45, P <0.001), anaemia prevalence 69.7% and 43.4% (P <0.001), and iron deficient erythropoiesis (low body iron) 8.0% and 11.7% (P = 0.088) respectively. Unlike other biomarkers the sTfR/logio ferritin ratio showed no correlation with inflammation as measured by CRP. Most biomarkers indicated reduced iron deficiency in early pregnancy, with the exception of haemoglobin. Body iron increased by 0.6-1.2 mg/kg in early gestation, did not differ by malaria status in nulliparae, but was higher in primigravidae with malaria (6.5 mg/kg versus 5.0 mg/kg; relative risk 1.53, 95% CI 0.67-2.38, P <0.001).

    Conclusion: In primigravidae, early pregnancy haemoglobin was not a good indicator of requirement for iron supplementation, which could be detrimental given the association of better iron status with increased malaria infection. (C) 2019 The Author(s). Published by Elsevier Ltd.

    Original languageEnglish
    JournalClinical Nutrition
    Volume39
    Issue number1
    Pages (from-to)204-214
    Number of pages11
    ISSN0261-5614
    DOIs
    Publication statusPublished - 2020

    Keywords

    • Iron biomarkers
    • Malaria
    • Inflammation
    • Pregnant
    • Non-pregnant
    • SOLUBLE TRANSFERRIN RECEPTOR
    • BIOMARKERS REFLECTING INFLAMMATION
    • PLASMA FERRITIN CONCENTRATION
    • NUTRITIONAL DETERMINANTS
    • PRESCHOOL-CHILDREN
    • REPRODUCTIVE AGE
    • ANTENATAL VISIT
    • SERUM FERRITIN
    • BODY IRON
    • ANEMIA

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