Marked age-dependent prevalence of symptomatic and patent infections and complexity of distribution of human Plasmodium species in central Vietnam

H.V. Nguyen, P. Van den Eede, C. Van Overmeir, N.D. Thang, L.X. Hung, Umberto D'Alessandro, A. Erhart

Research output: Contribution to journalA1: Web of Science-article

Abstract

In Vietnam, Plasmodium falciparum and P. vivax are responsible for most malaria infections, and P. malariae and P. ovale infections are rarely reported. Nevertheless, species-specific polymerase chain reaction analysis on 2,303 blood samples collected during a cross-sectional survey conducted in a forest area of central Vietnam identified 223 (9.7%) P. falciparum, 170 (7.4%) P. vivax, 95 (4.1%) P. malariae, and 19 (0.8%) P. ovale mono-infections and 164 (7.1%) mixed infections. Of the 671 Plasmodium-positive samples by polymerase chain reaction, only 331 were detected by microscopy. Microscopy poorly diagnosed P. malariae, P. ovale, and mixed infections. Clinical and sub-clinical infections occurred in all age groups. The risk for infection and disease decreased with age, probably because of acquired partial immunity. The common occurrence of sub-patent infections seems to indicate that the malaria burden is underestimated and that diagnostic and therapeutic policies should be adapted accordingly.
Original languageEnglish
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume87
Issue number6
Pages (from-to)989-995
Number of pages7
ISSN0002-9637
DOIs
Publication statusPublished - 2012

Keywords

  • Protozoal diseases
  • Malaria
  • Plasmodium falciparum
  • Plasmodium vivax
  • Plasmodium malariae
  • Plasmodium ovale
  • Vectors
  • Mosquitoes
  • Anopheles
  • Prevalence
  • Mixed infections
  • Distribution
  • Polymerase chain reaction
  • PCR
  • Microscopy
  • Diagnosis
  • Efficacy
  • Gametocytes
  • Risk factors
  • Age
  • Vietnam
  • Asia-Southeast

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