Maternal malaria but not schistosomiasis is associated with a higher risk of febrile infection in infant during the first 3 months of life: a mother-child cohort in Benin

Gino Agbota, Katja Polman, Frank T. Wieringa, Maiza Campos-Ponce, Manfred Accrombessi, Emmanuel Yovo, Clementine Roucher, Sem Ezinmegnon, Javier Yugueros Marcos, Laurence Vachot, Pierre Tissieres, Achille Massougbodji, Nadine Fievet, Michel Cot, Valerie Briand

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Abstract

Background

Malaria and schistosomiasis represent two of the most prevalent and disabling parasitic infections in developing countries. Few studies have evaluated the effect of maternal schistosomiasis and malaria in the peri-conceptional period on infant's risk of infection.

Methods

In Benin, women were followed from the preconception period until delivery. Subsequently, their children were followed from birth to 3 months of age. Pre-pregnancy malaria, malaria in pregnancy (MiP)-determined monthly using a thick blood smear-and urinary schistosomiasis-determined once before pregnancy and once at delivery using urine filtration-were the main maternal exposures. Infant's febrile infection (fever with respiratory, gastrointestinal and/or cutaneous clinical signs anytime during follow-up) was the main outcome. In a secondary analysis, we checked the relation of malaria and schistosomiasis with infant's hemoglobin (Hb) concentration. Both effects were separately assessed using logistic/mixed linear regression models.

Results

The prevalence of MiP was 35.7% with 10.8% occurring during the 1st trimester, and the prevalence of schistosomiasis was 21.8%. From birth to 3 months, 25.3% of infants had at least one episode of febrile infection. In multivariate analysis, MiP, particularly malaria in the 1st trimester, was significantly associated with a higher risk of infant's febrile infection (aOR = 4.99 [1.1; 22.6], p = 0.03). In secondary results, pre-pregnancy malaria and schistosomiasis were significantly associated with a lower infant's Hb concentration during the first 3 months.

Conclusion

We evidenced the deleterious effect of maternal parasitic infections on infant's health. Our results argue in favor of the implementation of preventive strategies as early as in the periconception.

Original languageEnglish
Article number0222864
JournalPLoS ONE
Volume14
Issue number9
Pages (from-to)e0222864
Number of pages13
ISSN1932-6203
DOIs
Publication statusPublished - 2019

Keywords

  • HEMOGLOBIN CONCENTRATION
  • EARLY-PREGNANCY
  • PREVALENCE
  • FALCIPARUM
  • RECEPTOR
  • ANEMIA

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