TY - JOUR
T1 - Methicillin-resistant Staphylococcus aureus bloodstream infections in hospitalized patients in Peru
AU - García, Coralith
AU - Hinostroza, Noemí
AU - Gordillo, Valeria
AU - Inchaustegui, Maria L
AU - Astocondor, Lizeth
AU - Chincha, Omayra
AU - Alejos, Saúl
AU - Olivera, Marco
AU - Bojórquez-Fernández, Digna
AU - Concha-Velasco, Fátima
AU - Vásquez, Nancy
AU - Castaneda-Sabogal, Alex
AU - Sullón, Pedro
AU - Fernández, Víctor
AU - Villegas-Chiroque, Miguel
AU - López, Enrique
AU - Hueda-Zavaleta, Miguel
AU - Vidaurre, Ana
AU - Bocángel, César
AU - Barco, Evelyn
AU - Paricahua, Eduardo
AU - Zervos, Marcus
AU - Jacobs, Jan
AU - Krapp, Fiorella
N1 - NPP
PY - 2023
Y1 - 2023
N2 - There is a knowledge gap in the epidemiology of methicillin-resistant Staphylococcus aureus (MRSA) causing bloodstream infections (BSIs) in Peru. Through a surveillance study in 13 hospitals of 10 Peruvian regions (2017-2019), we assessed the proportion of MRSA among S. aureus BSIs as well as the molecular typing of the isolates. A total of 166 S. aureus isolates were collected, and 36.1% of them were MRSA. Of note, MRSA isolates with phenotypic and genetic characteristics of the hospital-associated Chilean-Cordobes clone (multidrug-resistant SCCmec I, non-Panton-Valentine leukocidin [PVL] producers) were most commonly found (70%), five isolates with genetic characteristics of community-associated MRSA (CA-MRSA)-SCCmec IV, PVL-producer-(8.3%) were seen in three separate regions. These results demonstrate that hospital-associated MRSA is the most frequent MRSA found in patients with BSIs in Peru. They also show the emergence of S. aureus with genetic characteristics of CA-MRSA. Further studies are needed to evaluate the extension of CA-MRSA dissemination in Peru.
AB - There is a knowledge gap in the epidemiology of methicillin-resistant Staphylococcus aureus (MRSA) causing bloodstream infections (BSIs) in Peru. Through a surveillance study in 13 hospitals of 10 Peruvian regions (2017-2019), we assessed the proportion of MRSA among S. aureus BSIs as well as the molecular typing of the isolates. A total of 166 S. aureus isolates were collected, and 36.1% of them were MRSA. Of note, MRSA isolates with phenotypic and genetic characteristics of the hospital-associated Chilean-Cordobes clone (multidrug-resistant SCCmec I, non-Panton-Valentine leukocidin [PVL] producers) were most commonly found (70%), five isolates with genetic characteristics of community-associated MRSA (CA-MRSA)-SCCmec IV, PVL-producer-(8.3%) were seen in three separate regions. These results demonstrate that hospital-associated MRSA is the most frequent MRSA found in patients with BSIs in Peru. They also show the emergence of S. aureus with genetic characteristics of CA-MRSA. Further studies are needed to evaluate the extension of CA-MRSA dissemination in Peru.
KW - Anti-Bacterial Agents/pharmacology
KW - Community-Acquired Infections/epidemiology
KW - Exotoxins/genetics
KW - Humans
KW - Leukocidins/genetics
KW - Methicillin-Resistant Staphylococcus aureus/genetics
KW - Microbial Sensitivity Tests
KW - Peru/epidemiology
KW - Sepsis
KW - Staphylococcal Infections/epidemiology
KW - Staphylococcus aureus/genetics
U2 - 10.4269/ajtmh.23-0054
DO - 10.4269/ajtmh.23-0054
M3 - A1: Web of Science-article
C2 - 37722664
SN - 0002-9637
VL - 109
SP - 1118
EP - 1121
JO - American Journal of Tropical Medicine and Hygiene
JF - American Journal of Tropical Medicine and Hygiene
IS - 5
ER -