Michellamines D-F, new HIV-inhibitory dimeric naphthylisoquinoline alkaloids, and korupensamine E, a new antimalarial monomer, from Ancistrocladus korupensis

YF Hallock; KP Manfredi; JR Dai; JH Cardellina; RJ Gulakowski; JB McMahon; M Schaffer; M Stahl; KP Gulden; G Bringmann; G François; MR Boyd

doi:10.1021/np9700679

Michellamines D-F, new HIV-inhibitory dimeric naphthylisoquinoline alkaloids, and korupensamine E, a new antimalarial monomer, from Ancistrocladus korupensis

YF Hallock, KP Manfredi, JR Dai, JH Cardellina, RJ Gulakowski, JB McMahon, M Schaffer, M Stahl, KP Gulden, G Bringmann, G François, MR Boyd

Research output: Contribution to journal › A1: Web of Science-article › peer-review

Abstract

New monomeric (korupensamine E, 6) and dimeric (michellamines D-F, 7-9) naphthylisoquinoline alkaloids have been isolated from exracts of the tropical liana Ancistrocladus korupensis. Structures were determined by spectroanalytical methods, and stereochemistry was defined through NOE correlations, chemical degradation, and CD spectroscopy. Michellamines D-F exhibited in vitro HIV-inhibitory activity comparable to michellamine B, and korupensamine E exhibited in vitro antimalarial activity comparable to korupensamines A-D.

Original language	English
Journal	Journal of Natural Products
Volume	60
Issue number	7
Pages (from-to)	677-683
ISSN	0163-3864
DOIs	https://doi.org/10.1021/np9700679
Publication status	Published - 1997

Keywords

B780-tropical-medicine
Protozoal diseases
Malaria
Plasmodium falciparum
Vectors
Mosquitoes
Anopheles
Drug development
Antimalarials
Ancistrocladaceae

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10.1021/np9700679

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Hallock, YF., Manfredi, KP., Dai, JR., Cardellina, JH., Gulakowski, RJ., McMahon, JB., Schaffer, M., Stahl, M., Gulden, KP., Bringmann, G., François, G., & Boyd, MR. (1997). Michellamines D-F, new HIV-inhibitory dimeric naphthylisoquinoline alkaloids, and korupensamine E, a new antimalarial monomer, from Ancistrocladus korupensis. Journal of Natural Products, 60(7), 677-683. https://doi.org/10.1021/np9700679

@article{1b9dea7eb4644f2cba8aa5ccca2ffd27,

title = "Michellamines D-F, new HIV-inhibitory dimeric naphthylisoquinoline alkaloids, and korupensamine E, a new antimalarial monomer, from Ancistrocladus korupensis",

abstract = "New monomeric (korupensamine E, 6) and dimeric (michellamines D-F, 7-9) naphthylisoquinoline alkaloids have been isolated from exracts of the tropical liana Ancistrocladus korupensis. Structures were determined by spectroanalytical methods, and stereochemistry was defined through NOE correlations, chemical degradation, and CD spectroscopy. Michellamines D-F exhibited in vitro HIV-inhibitory activity comparable to michellamine B, and korupensamine E exhibited in vitro antimalarial activity comparable to korupensamines A-D.",

keywords = "B780-tropical-medicine, Protozoal diseases, Malaria, Plasmodium falciparum, Vectors, Mosquitoes, Anopheles, Drug development, Antimalarials, Ancistrocladaceae",

author = "YF Hallock and KP Manfredi and JR Dai and JH Cardellina and RJ Gulakowski and JB McMahon and M Schaffer and M Stahl and KP Gulden and G Bringmann and G Fran{\c c}ois and MR Boyd",

year = "1997",

doi = "10.1021/np9700679",

language = "English",

volume = "60",

pages = "677--683",

journal = "Journal of Natural Products",

issn = "0163-3864",

publisher = "American Chemical Society",

number = "7",

}

Hallock, YF, Manfredi, KP, Dai, JR, Cardellina, JH, Gulakowski, RJ, McMahon, JB, Schaffer, M, Stahl, M, Gulden, KP, Bringmann, G, François, G & Boyd, MR 1997, 'Michellamines D-F, new HIV-inhibitory dimeric naphthylisoquinoline alkaloids, and korupensamine E, a new antimalarial monomer, from Ancistrocladus korupensis', Journal of Natural Products, vol. 60, no. 7, pp. 677-683. https://doi.org/10.1021/np9700679

TY - JOUR

T1 - Michellamines D-F, new HIV-inhibitory dimeric naphthylisoquinoline alkaloids, and korupensamine E, a new antimalarial monomer, from Ancistrocladus korupensis

AU - Hallock, YF

AU - Manfredi, KP

AU - Dai, JR

AU - Cardellina, JH

AU - Gulakowski, RJ

AU - McMahon, JB

AU - Schaffer, M

AU - Stahl, M

AU - Gulden, KP

AU - Bringmann, G

AU - François, G

AU - Boyd, MR

PY - 1997

Y1 - 1997

N2 - New monomeric (korupensamine E, 6) and dimeric (michellamines D-F, 7-9) naphthylisoquinoline alkaloids have been isolated from exracts of the tropical liana Ancistrocladus korupensis. Structures were determined by spectroanalytical methods, and stereochemistry was defined through NOE correlations, chemical degradation, and CD spectroscopy. Michellamines D-F exhibited in vitro HIV-inhibitory activity comparable to michellamine B, and korupensamine E exhibited in vitro antimalarial activity comparable to korupensamines A-D.

AB - New monomeric (korupensamine E, 6) and dimeric (michellamines D-F, 7-9) naphthylisoquinoline alkaloids have been isolated from exracts of the tropical liana Ancistrocladus korupensis. Structures were determined by spectroanalytical methods, and stereochemistry was defined through NOE correlations, chemical degradation, and CD spectroscopy. Michellamines D-F exhibited in vitro HIV-inhibitory activity comparable to michellamine B, and korupensamine E exhibited in vitro antimalarial activity comparable to korupensamines A-D.

KW - B780-tropical-medicine

KW - Protozoal diseases

KW - Malaria

KW - Plasmodium falciparum

KW - Vectors

KW - Mosquitoes

KW - Anopheles

KW - Drug development

KW - Antimalarials

KW - Ancistrocladaceae

U2 - 10.1021/np9700679

DO - 10.1021/np9700679

M3 - A1: Web of Science-article

C2 - 9249970

SN - 0163-3864

VL - 60

SP - 677

EP - 683

JO - Journal of Natural Products

JF - Journal of Natural Products

IS - 7

ER -

Michellamines D-F, new HIV-inhibitory dimeric naphthylisoquinoline alkaloids, and korupensamine E, a new antimalarial monomer, from Ancistrocladus korupensis

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