Michellamines D-F, new HIV-inhibitory dimeric naphthylisoquinoline alkaloids, and korupensamine E, a new antimalarial monomer, from Ancistrocladus korupensis

YF Hallock, KP Manfredi, JR Dai, JH Cardellina, RJ Gulakowski, JB McMahon, M Schaffer, M Stahl, KP Gulden, G Bringmann, G François, MR Boyd

    Research output: Contribution to journalA1: Web of Science-article

    Abstract

    New monomeric (korupensamine E, 6) and dimeric (michellamines D-F, 7-9) naphthylisoquinoline alkaloids have been isolated from exracts of the tropical liana Ancistrocladus korupensis. Structures were determined by spectroanalytical methods, and stereochemistry was defined through NOE correlations, chemical degradation, and CD spectroscopy. Michellamines D-F exhibited in vitro HIV-inhibitory activity comparable to michellamine B, and korupensamine E exhibited in vitro antimalarial activity comparable to korupensamines A-D.
    Original languageEnglish
    JournalJournal of Natural Products
    Volume60
    Issue number7
    Pages (from-to)677-683
    ISSN0163-3864
    DOIs
    Publication statusPublished - 1997

    Keywords

    • B780-tropical-medicine
    • Protozoal diseases
    • Malaria
    • Plasmodium falciparum
    • Vectors
    • Mosquitoes
    • Anopheles
    • Drug development
    • Antimalarials
    • Ancistrocladaceae

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