Microscale granulation in a fluid bed powder processor using electrostatic atomisation

N. Kivikero, M. Murtomaa, B. Ingelbeen, O. Antikainen, E. Raesaenen, J. P. Mannermaa, A. M. Juppo

    Research output: Contribution to journalA1: Web of Science-article

    Abstract

    The aim of this study was to use the electrostatic atomisation in miniaturised fluid bed granulation process and define the effect of process parameters. The process parameters included in the study were granulation liquid flow rate, atomisation voltage and binder concentration in the granulation liquid. Altogether 22 batches were granulated in Multichamber Microscale Fluid bed powder Processor (MMFP). Granule size distributions were measured with both sieves and image analyses. With these process conditions, the atomisation liquid flow rate had a strong positive correlation with the granule size. Increasing the atomisation voltage increased the granule size, which is contradictory with the expectations. The effect of the binder concentration remained unclear. Although it is challenging to model the fluid bed granulation process in micro-scale, multivariate methods Such as principal component analysis (PCA) are helpful in studying the most important phenomena. (c) 2008 Elsevier B.V. All rights reserved.

    Original languageEnglish
    JournalEuropean Journal of Pharmaceutics and Biopharmaceutics
    Volume71
    Issue number1
    Pages (from-to)130-137
    Number of pages8
    ISSN0939-6411
    DOIs
    Publication statusPublished - 2009

    Keywords

    • Fluid bed granulation
    • Electrostatic atomisation
    • Micro-scale
    • Process parameters
    • Sieving
    • Lactose monohydrate
    • PHARMACEUTICAL POWDERS
    • GROWTH-KINETICS
    • FLUIDIZATION
    • GRANULES
    • SIZE

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